Skip to content

Study · Animal study (in vivo) · dog · 2014

7 results

New evidence implicating 4-hydroxynonenal in the pathogenesis of osteoarthritis in vivo.

Shi Q, Abusarah J, Zaouter C, Moldovan F, Fernandes JC, Fahmi H, Benderdour M

Arthritis & rheumatology (Hoboken, N.J.)1 Sept 2014Cited by 27 (Europe PMC)

PMID24838404 (opens in a new tab)DOI10.1002/art.38704 (opens in a new tab)PepBankPUB-24838404
Publisher pagePubMedAsk about this study
Jump to 7 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In dogs after ACLT, carnosine reduced osteoarthritis cartilage lesion severity versus placebo.

    In plain wordsIn dogs after knee ligament surgery, carnosine reduced cartilage lesion severity compared with placebo.

    Peptide
    L-carnosine
    Outcome
    DecreaseCartilage lesion severity
    Study

    dogsn: not reported in source

    anterior cruciate ligament transection-induced osteoarthritis
    Comparator
    placebo
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    5 or 20 mg/kg/day · oralAs given in this study (dogs).

    Source sentences

    Summary
    In dogs that had undergone ACLT, carnosine treatment reduced the severity and histopathology score of OA cartilage lesions and also decreased HNE-protein adducts, pentosidine, nitrosylated proteins, cartilage-degrading enzymes, and markers of inflammation.
    3 context sentences
    Summary · context
    In the first experimental protocol, OA was induced by anterior cruciate ligament transection (ACLT) of the right knees of crossbred dogs (n = 6 per group).
    Summary · context
    The animals were treated with placebo or HNE-trapping carnosine (5 or 20 mg/kg/day) orally for 8 weeks.
    Summary · context
    Another group of dogs was treated for 4 weeks with 20 mg/kg/day of carnosine starting 4 weeks after surgery.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In dogs after ACLT, carnosine reduced the histopathology score of cartilage lesions versus placebo.

    In plain wordsIn dogs after knee ligament surgery, carnosine reduced cartilage damage scores compared with placebo.

    Peptide
    L-carnosine
    Outcome
    DecreaseCartilage lesion histopathology score
    Study

    dogsn: not reported in source

    anterior cruciate ligament transection-induced osteoarthritis
    Comparator
    placebo
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    5 or 20 mg/kg/day · oralAs given in this study (dogs).

    Source sentences

    Summary
    In dogs that had undergone ACLT, carnosine treatment reduced the severity and histopathology score of OA cartilage lesions and also decreased HNE-protein adducts, pentosidine, nitrosylated proteins, cartilage-degrading enzymes, and markers of inflammation.
    3 context sentences
    Summary · context
    In the first experimental protocol, OA was induced by anterior cruciate ligament transection (ACLT) of the right knees of crossbred dogs (n = 6 per group).
    Summary · context
    The animals were treated with placebo or HNE-trapping carnosine (5 or 20 mg/kg/day) orally for 8 weeks.
    Summary · context
    Another group of dogs was treated for 4 weeks with 20 mg/kg/day of carnosine starting 4 weeks after surgery.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In dogs after ACLT, carnosine decreased HNE-protein adducts versus placebo.

    In plain wordsIn dogs after knee ligament surgery, carnosine reduced HNE-protein adducts compared with placebo.

    Peptide
    L-carnosine
    Outcome
    DecreaseHNE-protein adducts
    Study

    dogsn: not reported in source

    anterior cruciate ligament transection-induced osteoarthritis
    Comparator
    placebo
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    5 or 20 mg/kg/day · oralAs given in this study (dogs).

    Source sentences

    Summary
    In dogs that had undergone ACLT, carnosine treatment reduced the severity and histopathology score of OA cartilage lesions and also decreased HNE-protein adducts, pentosidine, nitrosylated proteins, cartilage-degrading enzymes, and markers of inflammation.
    3 context sentences
    Summary · context
    In the first experimental protocol, OA was induced by anterior cruciate ligament transection (ACLT) of the right knees of crossbred dogs (n = 6 per group).
    Summary · context
    The animals were treated with placebo or HNE-trapping carnosine (5 or 20 mg/kg/day) orally for 8 weeks.
    Summary · context
    Another group of dogs was treated for 4 weeks with 20 mg/kg/day of carnosine starting 4 weeks after surgery.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In dogs after ACLT, carnosine decreased pentosidine versus placebo.

    In plain wordsIn dogs after knee ligament surgery, carnosine reduced pentosidine compared with placebo.

    Peptide
    L-carnosine
    Outcome
    DecreasePentosidine
    Study

    dogsn: not reported in source

    anterior cruciate ligament transection-induced osteoarthritis
    Comparator
    placebo
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    5 or 20 mg/kg/day · oralAs given in this study (dogs).

    Source sentences

    Summary
    In dogs that had undergone ACLT, carnosine treatment reduced the severity and histopathology score of OA cartilage lesions and also decreased HNE-protein adducts, pentosidine, nitrosylated proteins, cartilage-degrading enzymes, and markers of inflammation.
    3 context sentences
    Summary · context
    In the first experimental protocol, OA was induced by anterior cruciate ligament transection (ACLT) of the right knees of crossbred dogs (n = 6 per group).
    Summary · context
    The animals were treated with placebo or HNE-trapping carnosine (5 or 20 mg/kg/day) orally for 8 weeks.
    Summary · context
    Another group of dogs was treated for 4 weeks with 20 mg/kg/day of carnosine starting 4 weeks after surgery.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In dogs after ACLT, carnosine decreased nitrosylated proteins versus placebo.

    In plain wordsIn dogs after knee ligament surgery, carnosine reduced nitrosylated proteins compared with placebo.

    Peptide
    L-carnosine
    Outcome
    DecreaseNitrosylated proteins
    Study

    dogsn: not reported in source

    anterior cruciate ligament transection-induced osteoarthritis
    Comparator
    placebo
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    5 or 20 mg/kg/day · oralAs given in this study (dogs).

    Source sentences

    Summary
    In dogs that had undergone ACLT, carnosine treatment reduced the severity and histopathology score of OA cartilage lesions and also decreased HNE-protein adducts, pentosidine, nitrosylated proteins, cartilage-degrading enzymes, and markers of inflammation.
    3 context sentences
    Summary · context
    In the first experimental protocol, OA was induced by anterior cruciate ligament transection (ACLT) of the right knees of crossbred dogs (n = 6 per group).
    Summary · context
    The animals were treated with placebo or HNE-trapping carnosine (5 or 20 mg/kg/day) orally for 8 weeks.
    Summary · context
    Another group of dogs was treated for 4 weeks with 20 mg/kg/day of carnosine starting 4 weeks after surgery.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In dogs after ACLT, carnosine decreased cartilage-degrading enzymes versus placebo.

    In plain wordsIn dogs after knee ligament surgery, carnosine reduced cartilage-degrading enzymes compared with placebo.

    Peptide
    L-carnosine
    Outcome
    DecreaseCartilage-degrading enzymes
    Study

    dogsn: not reported in source

    anterior cruciate ligament transection-induced osteoarthritis
    Comparator
    placebo
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    5 or 20 mg/kg/day · oralAs given in this study (dogs).

    Source sentences

    Summary
    In dogs that had undergone ACLT, carnosine treatment reduced the severity and histopathology score of OA cartilage lesions and also decreased HNE-protein adducts, pentosidine, nitrosylated proteins, cartilage-degrading enzymes, and markers of inflammation.
    3 context sentences
    Summary · context
    In the first experimental protocol, OA was induced by anterior cruciate ligament transection (ACLT) of the right knees of crossbred dogs (n = 6 per group).
    Summary · context
    The animals were treated with placebo or HNE-trapping carnosine (5 or 20 mg/kg/day) orally for 8 weeks.
    Summary · context
    Another group of dogs was treated for 4 weeks with 20 mg/kg/day of carnosine starting 4 weeks after surgery.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In dogs after ACLT, carnosine decreased inflammation markers versus placebo.

    In plain wordsIn dogs after knee ligament surgery, carnosine reduced inflammation markers compared with placebo.

    Peptide
    L-carnosine
    Outcome
    DecreaseInflammation markers
    Study

    dogsn: not reported in source

    anterior cruciate ligament transection-induced osteoarthritis
    Comparator
    placebo
    Outcome group
    Inflammation markers · Musculoskeletal
    Studied dose
    5 or 20 mg/kg/day · oralAs given in this study (dogs).

    Source sentences

    Summary
    In dogs that had undergone ACLT, carnosine treatment reduced the severity and histopathology score of OA cartilage lesions and also decreased HNE-protein adducts, pentosidine, nitrosylated proteins, cartilage-degrading enzymes, and markers of inflammation.
    3 context sentences
    Summary · context
    In the first experimental protocol, OA was induced by anterior cruciate ligament transection (ACLT) of the right knees of crossbred dogs (n = 6 per group).
    Summary · context
    The animals were treated with placebo or HNE-trapping carnosine (5 or 20 mg/kg/day) orally for 8 weeks.
    Summary · context
    Another group of dogs was treated for 4 weeks with 20 mg/kg/day of carnosine starting 4 weeks after surgery.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.