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Study · Animal study (in vivo) · mouse · 2014

3 results

Leptin-responsive GABAergic neurons regulate fertility through pathways that result in reduced kisspeptinergic tone.

Martin C, Navarro VM, Simavli S, Vong L, Carroll RS, Lowell BB, Kaiser UB

The Journal of neuroscience : the official journal of the Society for Neuroscience1 Apr 2014Cited by 62 (Europe PMC)

PMID24760864 (opens in a new tab)PMCIDPMC3996222 (opens in a new tab)DOI10.1523/jneurosci.3003-13.2014 (opens in a new tab)PepBankPUB-24760864
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study3

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In female mice lacking the leptin receptor in GABAergic neurons, intracerebroventricular kisspeptin‑10 elicited robust gonadotropin responses.

    In plain wordsIn female mice lacking leptin receptors in certain nerve cells, kisspeptin‑10 given into the brain caused strong gonadotropin release.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseGonadotropin response to kisspeptin-10
    Study

    mousen: not reported in source

    female Vgat-Cre;Lepr(lox/lox) mice (leptin receptor ablated in GABAergic neurons)
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (mouse).

    Source sentences

    Summary
    Intracerebroventricular administration of kisspeptin-10 to Vgat-Cre;Lepr(lox/lox) female mice elicited robust gonadotropin responses, suggesting normal gonadotropin-releasing hormone neuronal and gonadotrope function.
    1 context sentence
    Summary · context
    To address this gap, we explored the contribution of predominantly inhibitory (GABAergic) neurons versus excitatory (glutamatergic) neurons in the female mouse by selective ablation of the leptin receptor in each neuronal population: Vgat-Cre;Lepr(lox/lox) and Vglut2-Cre;Lepr(lox/lox) mice, respectively.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 02AnimalEndogenous levelAnimal study (in vivo)Other

    In ovariectomized female mice lacking the leptin receptor in GABAergic neurons, Kiss1 mRNA in the arcuate nucleus was significantly lower than in control animals.

    In plain wordsIn these mice, the body's own kisspeptin gene activity in the arcuate nucleus was lower than in control mice.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseKiss1 mRNA in the arcuate nucleus
    Study

    mousen: not reported in source

    female Vgat-Cre;Lepr(lox/lox) mice (leptin receptor ablated in GABAergic neurons)
    Comparator
    Control mice
    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    However, adult ovariectomized Vgat-Cre;Lepr(lox/lox) mice displayed significantly reduced levels of Kiss1 (but not Tac2) mRNA in the arcuate nucleus, and a reduced compensatory luteinizing hormone increase compared with control animals.
    1 context sentence
    Summary · context
    To address this gap, we explored the contribution of predominantly inhibitory (GABAergic) neurons versus excitatory (glutamatergic) neurons in the female mouse by selective ablation of the leptin receptor in each neuronal population: Vgat-Cre;Lepr(lox/lox) and Vglut2-Cre;Lepr(lox/lox) mice, respectively.

    This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.

  2. 03AnimalEndogenous levelAnimal study (in vivo)Other

    In female mice lacking the leptin receptor in GABAergic neurons, Kiss1 mRNA in the AVPV was significantly lower than in Lepr(lox/lox) mice.

    In plain wordsIn these mice, the body's own kisspeptin gene activity in the AVPV brain area was lower than in control mice.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseKiss1 mRNA in the AVPV
    Study

    mousen: not reported in source

    female Vgat-Cre;Lepr(lox/lox) mice (leptin receptor ablated in GABAergic neurons)
    Comparator
    Lepr(lox/lox) mice
    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    These animals also exhibited a compromised positive feedback response to sex steroids, as shown by significantly lower Kiss1 mRNA levels in the AVPV, compared with Lepr(lox/lox) mice.
    1 context sentence
    Summary · context
    To address this gap, we explored the contribution of predominantly inhibitory (GABAergic) neurons versus excitatory (glutamatergic) neurons in the female mouse by selective ablation of the leptin receptor in each neuronal population: Vgat-Cre;Lepr(lox/lox) and Vglut2-Cre;Lepr(lox/lox) mice, respectively.

    This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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