One dose of oral hexarelin protects chronic cardiac function after myocardial infarction.

Mao Y, Tokudome T, Kishimoto I, Otani K, Miyazato M, Kangawa K

Peptides18 Apr 2014Cited by 10 (Europe PMC)

PMID24747279DOI10.1016/j.peptides.2014.04.004PepBankPUB-24747279

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In mice with myocardial infarction, one oral dose of hexarelin did not change mortality within 14 days compared with vehicle.
In plain wordsIn mice with a heart attack, one oral dose of hexarelin did not change deaths within 14 days compared with vehicle.
Peptide
Hexarelin
Outcome
No significant changeMortality within 14 days after myocardial infarction
Study
mousen: not reported in source
Mouse model of myocardial infarction (left coronary artery ligation)
Comparator
Vehicle
Outcome group
Mortality · Cardiovascular
Studied dose
single dose · oral gavage · single doseAs given in this study (mouse).
Source sentences
Summary
Although the mortality within 14 days after myocardial infarction did not differ between the groups
1 context sentence(design, population, supporting numbers)
Summary · context
Myocardial infarction or sham operation was generated by left coronary artery ligation in male C57BL/6J mice, which subsequently received one dose of hexarelin or vehicle treatment by oral gavage 30 min after operation.
Report a problemFND-2474727901
02AnimalAnimal study (in vivo)Efficacy outcome
In mice with myocardial infarction, one oral dose of hexarelin gave a higher ejection fraction in the chronic phase than vehicle.
In plain wordsIn mice with a heart attack, one oral dose of hexarelin led to better heart pumping later on than vehicle.
Peptide
Hexarelin
Outcome
IncreaseEjection fraction
Study
mousen: not reported in source
Mouse model of myocardial infarction (left coronary artery ligation)
Comparator
Vehicle
Outcome group
Heart function · Cardiovascular
Studied dose
single dose · oral gavage · single doseAs given in this study (mouse).
Source sentences
Summary
hexarelin treatment protected cardiac function in the chronic phase as evidenced by higher ejection fraction and fractional shortening
1 context sentence(design, population, supporting numbers)
Summary · context
Myocardial infarction or sham operation was generated by left coronary artery ligation in male C57BL/6J mice, which subsequently received one dose of hexarelin or vehicle treatment by oral gavage 30 min after operation.
Report a problemFND-2474727902
03AnimalAnimal study (in vivo)Efficacy outcome
In mice with myocardial infarction, one oral dose of hexarelin gave a higher fractional shortening in the chronic phase than vehicle.
In plain wordsIn mice with a heart attack, one oral dose of hexarelin led to stronger heart muscle shortening later on than vehicle.
Peptide
Hexarelin
Outcome
IncreaseFractional shortening
Study
mousen: not reported in source
Mouse model of myocardial infarction (left coronary artery ligation)
Comparator
Vehicle
Outcome group
Heart function · Cardiovascular
Studied dose
single dose · oral gavage · single doseAs given in this study (mouse).
Source sentences
Summary
hexarelin treatment protected cardiac function in the chronic phase as evidenced by higher ejection fraction and fractional shortening
1 context sentence(design, population, supporting numbers)
Summary · context
Myocardial infarction or sham operation was generated by left coronary artery ligation in male C57BL/6J mice, which subsequently received one dose of hexarelin or vehicle treatment by oral gavage 30 min after operation.
Report a problemFND-2474727903
04AnimalAnimal study (in vivo)Efficacy outcome
In mice with myocardial infarction, one oral dose of hexarelin gave lower lung weight to body weight and lung weight to tibial length ratios than vehicle.
In plain wordsIn mice with a heart attack, one oral dose of hexarelin led to less lung fluid build-up than vehicle, shown by lung weight ratios.
Peptide
Hexarelin
Outcome
DecreaseLung weight ratios
Study
mousen: not reported in source
Mouse model of myocardial infarction (left coronary artery ligation)
Comparator
Vehicle
Outcome group
Heart function · Cardiovascular
Studied dose
single dose · oral gavage · single doseAs given in this study (mouse).
Source sentences
Summary
as well as lower lung weight/body weight and lung weight/tibial length ratios, compared with vehicle treatment.
1 context sentence(design, population, supporting numbers)
Summary · context
Myocardial infarction or sham operation was generated by left coronary artery ligation in male C57BL/6J mice, which subsequently received one dose of hexarelin or vehicle treatment by oral gavage 30 min after operation.
Report a problemFND-2474727904
05AnimalAnimal study (in vivo)Efficacy outcome
In mice with myocardial infarction, hexarelin lowered plasma epinephrine levels.
In plain wordsIn mice with a heart attack, hexarelin lowered blood levels of the stress hormone epinephrine.
Peptide
Hexarelin
Outcome
DecreasePlasma epinephrine
Study
mousen: not reported in source
Mouse model of myocardial infarction (left coronary artery ligation)
Comparator
Vehicle
Outcome group
Heart function · Endocrine and hormones
Studied dose
single dose · oral gavage · single doseAs given in this study (mouse).
Source sentences
Summary
Hexarelin treatment concurrently lowered plasma epinephrine and dopamine levels
1 context sentence(design, population, supporting numbers)
Summary · context
Myocardial infarction or sham operation was generated by left coronary artery ligation in male C57BL/6J mice, which subsequently received one dose of hexarelin or vehicle treatment by oral gavage 30 min after operation.
Report a problemFND-2474727905
06AnimalAnimal study (in vivo)Efficacy outcome
In mice with myocardial infarction, hexarelin lowered plasma dopamine levels.
In plain wordsIn mice with a heart attack, hexarelin lowered blood levels of dopamine.
Peptide
Hexarelin
Outcome
DecreasePlasma dopamine
Study
mousen: not reported in source
Mouse model of myocardial infarction (left coronary artery ligation)
Comparator
Vehicle
Outcome group
Heart function · Endocrine and hormones
Studied dose
single dose · oral gavage · single doseAs given in this study (mouse).
Source sentences
Summary
Hexarelin treatment concurrently lowered plasma epinephrine and dopamine levels
1 context sentence(design, population, supporting numbers)
Summary · context
Myocardial infarction or sham operation was generated by left coronary artery ligation in male C57BL/6J mice, which subsequently received one dose of hexarelin or vehicle treatment by oral gavage 30 min after operation.
Report a problemFND-2474727906
07AnimalAnimal study (in vivo)Mechanism
In mice with myocardial infarction, hexarelin shifted autonomic balance toward parasympathetic activity, with a smaller low/high-frequency power ratio and larger normalized high-frequency power.
In plain wordsIn mice with a heart attack, hexarelin shifted nerve control of the heart toward the calming parasympathetic side.
Peptide
Hexarelin
Outcome
IncreaseAutonomic balance toward parasympathetic activity on heart rate variability
Study
mousen: not reported in source
Mouse model of myocardial infarction (left coronary artery ligation)
Comparator
Vehicle
Outcome group
Heart function · Cardiovascular
Studied dose
single dose · oral gavage · single doseAs given in this study (mouse).
Source sentences
Summary
shifted the balance of autonomic nervous activity toward parasympathetic nervous activity as evidenced by a smaller low/high-frequency power ratio and larger normalized high-frequency power on heart rate variability analysis.
1 context sentence(design, population, supporting numbers)
Summary · context
Myocardial infarction or sham operation was generated by left coronary artery ligation in male C57BL/6J mice, which subsequently received one dose of hexarelin or vehicle treatment by oral gavage 30 min after operation.
Report a problemFND-2474727907

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

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