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Study · Animal study (in vivo) · 2013

6 results

[Comparative study of immunomodulatory activity of peptides, tinrostim and thymalin].

Kuznetsova TA, Besednova NN, Zaporozhets TS, Smolina TP, Kazha AK, Ivanushko LA

Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic]1 Jan 2013

PMID24734422 (opens in a new tab)PepBankPUB-24734422
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In experimental animals, thymalin had humoral immune stimulation comparable to tinrostim.

    In plain wordsIn animals, thymalin stimulated antibody responses to a degree comparable to tinrostim.

    Peptide
    Thymalin
    Outcome
    No significant changeHumoral immune response
    Study

    n: not reported in source

    Experimental animals
    Comparator
    Tinrostim
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Tinrostim showed a stimulating effect on the humoral and cellular nimmune responses when administered parenterally in experimental animals, as well as on the phagocytic activity of neutrophils, comparable to the effect of thymalin.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In experimental animals, thymalin had cellular immune stimulation comparable to tinrostim.

    In plain wordsIn animals, thymalin stimulated cellular immune responses to a degree comparable to tinrostim.

    Peptide
    Thymalin
    Outcome
    No significant changeCellular immune response
    Study

    n: not reported in source

    Experimental animals
    Comparator
    Tinrostim
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Tinrostim showed a stimulating effect on the humoral and cellular nimmune responses when administered parenterally in experimental animals, as well as on the phagocytic activity of neutrophils, comparable to the effect of thymalin.
  3. 03AnimalAnimal study (in vivo)Activity measurement

    In experimental animals, thymalin stimulated neutrophil phagocytic activity comparably to tinrostim.

    In plain wordsIn animals, thymalin stimulated neutrophil activity to a degree comparable to tinrostim.

    Peptide
    Thymalin
    Outcome
    No significant changeNeutrophil phagocytic activity
    Study

    n: not reported in source

    Experimental animals
    Comparator
    Tinrostim
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Tinrostim showed a stimulating effect on the humoral and cellular nimmune responses when administered parenterally in experimental animals, as well as on the phagocytic activity of neutrophils, comparable to the effect of thymalin.
  4. 04LabIn vitro (cells)Mechanism

    In peripheral blood cell cultures, thymalin increased TNFa production.

    In plain wordsIn cells, thymalin increased production of TNFa.

    Peptide
    Thymalin
    Outcome
    IncreaseTNFa production
    Study

    n: not reported in source

    Intact peripheral blood cells
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    It was demonstrated that both the peptide drugs increased the production of pro-(TNFa, IL-1) and antiinflammatory (IL- 10) cytokines in the culture of intact cells of peripheral blood in vitro.
  5. 05LabIn vitro (cells)Mechanism

    In peripheral blood cell cultures, thymalin increased IL-1 production.

    In plain wordsIn cells, thymalin increased production of IL-1.

    Peptide
    Thymalin
    Outcome
    IncreaseIL-1 production
    Study

    n: not reported in source

    Intact peripheral blood cells
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    It was demonstrated that both the peptide drugs increased the production of pro-(TNFa, IL-1) and antiinflammatory (IL- 10) cytokines in the culture of intact cells of peripheral blood in vitro.
  6. 06LabIn vitro (cells)Mechanism

    In peripheral blood cell cultures, thymalin increased IL-10 production.

    In plain wordsIn cells, thymalin increased production of IL-10.

    Peptide
    Thymalin
    Outcome
    IncreaseIL-10 production
    Study

    n: not reported in source

    Intact peripheral blood cells
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    It was demonstrated that both the peptide drugs increased the production of pro-(TNFa, IL-1) and antiinflammatory (IL- 10) cytokines in the culture of intact cells of peripheral blood in vitro.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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