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Study · In vitro (cells) · chicken receptor · 2014

1 result

Analysis of the pharmacological properties of chicken melanocortin-2 receptor (cMC2R) and chicken melanocortin-2 accessory protein 1 (cMRAP1).

Barlock TK, Gehr DT, Dores RM

General and comparative endocrinology12 Apr 2014Cited by 17 (Europe PMC)

PMID24726989 (opens in a new tab)DOI10.1016/j.ygcen.2014.03.045 (opens in a new tab)PepBankPUB-24726989
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In CHO cells expressing chicken MC2R and MRAP1, NDP-MSH did not stimulate the cells, whereas hACTH(1-24) did.

    In plain wordsIn lab cells carrying the chicken MC2R receptor, NDP-MSH did not activate the receptor, but ACTH did.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    No significant changecAMP response of cMC2R/cMRAP1 cells to NDP-MSH
    Study

    chicken receptorn: not reported in source

    CHO cells expressing chicken MC2R and MRAP1
    Comparator
    hACTH(1-24)
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    up to 10(-7)MAs given in this study (chicken receptor).

    Source sentences

    Summary
    The transiently transfected CHO cells responded in a robust manner to stimulation by hACTH(1-24) (EC50 value=2.7 × 10(-12)M +/- 1.3 × 10(-12)), but the transfected CHO cells could not be stimulated by NDP-MSH at concentrations as high as 10(-7)M.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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