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Study · Measured the body's own peptide · 2014

1 result

The anti-promyelocytic leukemia mode of action of two endophytic secondary metabolites unveiled by a proteomic approach.

Gallo MB, Falso MJ, Balem F, Menezes D, Rocha N, Balachandran R, Sturgeon TS, Pupo MT, Day BW

Planta medica7 Apr 2014Cited by 4 (Europe PMC)

PMID24710897 (opens in a new tab)DOI10.1055/s-0034-1368301 (opens in a new tab)PepBankPUB-24710897
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

No result from this study comes from a test of the peptide.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01LabEndogenous levelIn vitro (cells)Mechanism

    In HL-60 leukaemia cells, aphidicolin increased the cells' own thymosin beta‑4 expression, together with RhoGDI2 and 14-3-3 proteins.

    In plain wordsIn leukaemia cells in the lab, the drug aphidicolin raised the cells' own thymosin beta‑4.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseTβ4 protein expression after aphidicolin
    Study

    humann: not reported in source

    HL-60 cells treated with aphidicolin
    Outcome group
    Endogenous peptide levels · Cancer

    Source sentences

    Summary
    In addition, protein expression profiles also revealed that aphidicolin is able to influence microtubule dynamics, modulate proteasome activator complex expression, and control the inflammatory cascade through overexpression of thymosin beta 4, RhoGDI2, and 14-3-3 proteins.
    1 context sentence
    Summary · context
    As a result of a program to find antitumor compounds of endophytes from medicinal Asteraceae, the steroid (22E,24R)-8,14-epoxyergosta-4,22-diene-3,6-dione (a) and the diterpene aphidicolin (b) were isolated from the filamentous fungi Papulaspora immersa and Nigrospora sphaerica, respectively, and ex…

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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