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Study · Not a test of the peptide alone · 2014

2 results

Thymosin β4 coated nanofiber scaffolds for the repair of damaged cardiac tissue.

Kumar A, Patel A, Duvalsaint L, Desai M, Marks ED

Journal of nanobiotechnology24 Mar 2014Cited by 16 (Europe PMC)

PMID24661328 (opens in a new tab)PMCIDPMC3996948 (opens in a new tab)DOI10.1186/1477-3155-12-10 (opens in a new tab)PepBankPUB-24661328
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Summary

After a cardiac event, proper treatment and care of the damaged tissue is crucial in restoring optimal cardiac function and preventing future cardiac events. Recently, thymosin β4 has been found to play a vital role in cardiac cell health and development by regulating angiogenesis, inflammatory responses, and wound healing. We proposed that defined poly(ϵ-caprolactone) (PCL) nanoscaffolds coated with thymosin β4 could efficiently differentiate murine-derived cardiomyocytes into functioning cardiac tissue. PCL nanoscaffolds were developed through electrospinning technology, and subsequently coated with a thymosin β4 solution. Cardiomyocytes were seeded on coated and uncoated nanoscaffolds and observed for six days via fluorescent and electron microscopy. Our results demonstrated a robust growth and differentiation of cardiomyocytes on coated nanoscaffolds compared with uncoated, showing potential for nanoscaffold-mediated cardiac cell replacement in vivo after an MI or other cardiac event.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin beta-4 (human).

  1. 01LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Efficacy outcome

    In murine-derived cardiomyocytes, growth was more robust on thymosin β4-coated nanoscaffolds than on uncoated ones.

    In plain wordsIn lab-grown mouse heart cells, growth was stronger on nanofiber scaffolds coated with Tβ4 than on uncoated scaffolds.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseCardiomyocyte growth on coated scaffolds
    Study

    mousen: not reported in source

    Murine-derived cardiomyocytes on Tβ4-coated PCL nanoscaffolds
    Comparator
    Uncoated nanoscaffolds
    Outcome group
    Heart function · Cardiovascular

    Source sentences

    Summary
    Our results demonstrated a robust growth and differentiation of cardiomyocytes on coated nanoscaffolds compared with uncoated
    1 context sentence
    Summary · context
    Cardiomyocytes were seeded on coated and uncoated nanoscaffolds and observed for six days via fluorescent and electron microscopy.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  2. 02LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Efficacy outcome

    In murine-derived cardiomyocytes, differentiation was more robust on thymosin β4-coated nanoscaffolds than on uncoated ones.

    In plain wordsIn lab-grown mouse heart cells, maturation was stronger on nanofiber scaffolds coated with Tβ4 than on uncoated scaffolds.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseCardiomyocyte differentiation on coated scaffolds
    Study

    mousen: not reported in source

    Murine-derived cardiomyocytes on Tβ4-coated PCL nanoscaffolds
    Comparator
    Uncoated nanoscaffolds
    Outcome group
    Heart function · Cardiovascular

    Source sentences

    Summary
    Our results demonstrated a robust growth and differentiation of cardiomyocytes on coated nanoscaffolds compared with uncoated
    1 context sentence
    Summary · context
    Cardiomyocytes were seeded on coated and uncoated nanoscaffolds and observed for six days via fluorescent and electron microscopy.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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