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Study · Randomized controlled trial · n = 42 · 2014

6 results

Evaluation of the effect of GnRH agonist on menstrual reverse in breast cancer cases treated with cyclophosphamide.

Karimi-Zarchi M, Forat-Yazdi M, Vafaeenasab MR, Nakhaie-Moghadam M, Miratashi-Yazdi A, Teimoori S, Dehghani-Tafti A

European journal of gynaecological oncology1 Jan 2014Cited by 29 (Europe PMC)

PMID24654464 (opens in a new tab)PepBankPUB-24654464
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. 6 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In women with breast cancer, diphereline increased menstrual recovery versus chemotherapy controls at three to six months after treatment.

    In plain wordsWomen receiving diphereline had more menstrual recovery than chemotherapy controls at three to six months after treatment.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    IncreaseMenstrual recovery
    Study

    n = 42

    Comparator
    Chemotherapy without diphereline
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Measurements

    Menstrual recovery
    90.5%
    diphereline
    Menstrual recovery
    33.3%
    control

    Source sentences

    Summary
    Spontaneous menstrual reverse occurred in 90.5% of patients receiving diphereline at three to six months after treatment which occurred in 33.3% of control cases.
    4 context sentences
    Summary · context
    It should be noted that there was a significant difference between controls and cases (p < 0.001).
    Summary · context
    This randomized clinical trial (RCT) was conducted on 42 adenocarcinoma cases.
    Summary · context
    Primary stages to Stage II (T2N1M0) whose histology reports were negative ER/PR were enrolled in this study.
    Summary · context
    All the enrolled patients were candidates for cyclophosphamide (600 mg/m2), adriamycin (60 mg/m2), and taxoter (75 mg/m2) chemotherapy regimens.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In women with breast cancer, diphereline lowered FSH during treatment and three months afterward versus chemotherapy controls.

    In plain wordsWomen receiving diphereline had lower FSH during treatment and three months afterward than chemotherapy controls.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreaseFSH
    Study

    n = 42

    Comparator
    Chemotherapy without diphereline
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Mean serum level of follicle stimulating hormone (FSH) and luteinizing hormone (LH) during and at three months after therapy was significantly lower in cases in comparison with controls,
    3 context sentences
    Summary · context
    This randomized clinical trial (RCT) was conducted on 42 adenocarcinoma cases.
    Summary · context
    Primary stages to Stage II (T2N1M0) whose histology reports were negative ER/PR were enrolled in this study.
    Summary · context
    All the enrolled patients were candidates for cyclophosphamide (600 mg/m2), adriamycin (60 mg/m2), and taxoter (75 mg/m2) chemotherapy regimens.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In women with breast cancer, diphereline lowered LH during treatment and three months afterward versus chemotherapy controls.

    In plain wordsWomen receiving diphereline had lower LH during treatment and three months afterward than chemotherapy controls.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreaseLH
    Study

    n = 42

    Comparator
    Chemotherapy without diphereline
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Mean serum level of follicle stimulating hormone (FSH) and luteinizing hormone (LH) during and at three months after therapy was significantly lower in cases in comparison with controls,
    3 context sentences
    Summary · context
    This randomized clinical trial (RCT) was conducted on 42 adenocarcinoma cases.
    Summary · context
    Primary stages to Stage II (T2N1M0) whose histology reports were negative ER/PR were enrolled in this study.
    Summary · context
    All the enrolled patients were candidates for cyclophosphamide (600 mg/m2), adriamycin (60 mg/m2), and taxoter (75 mg/m2) chemotherapy regimens.
  4. 04HumanRandomized controlled trialEfficacy outcome

    In women with breast cancer, diphereline increased estradiol three months after chemotherapy versus chemotherapy controls.

    In plain wordsWomen receiving diphereline had higher estradiol three months after chemotherapy than chemotherapy controls.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    IncreaseEstradiol
    Study

    n = 42

    Comparator
    Chemotherapy without diphereline
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    but serum level of estradiol was significantly more in cases three months after chemotherapy (p < 0.001).
    3 context sentences
    Summary · context
    This randomized clinical trial (RCT) was conducted on 42 adenocarcinoma cases.
    Summary · context
    Primary stages to Stage II (T2N1M0) whose histology reports were negative ER/PR were enrolled in this study.
    Summary · context
    All the enrolled patients were candidates for cyclophosphamide (600 mg/m2), adriamycin (60 mg/m2), and taxoter (75 mg/m2) chemotherapy regimens.
  5. 05HumanRandomized controlled trialEfficacy outcome

    In women with breast cancer younger than 35 years, menstrual recovery did not significantly differ between diphereline and chemotherapy controls.

    In plain wordsWomen younger than 35 had similar menstrual recovery with diphereline and chemotherapy controls.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    No significant changeMenstrual recovery below age 35
    Study

    n: not reported in source

    Comparator
    Chemotherapy without diphereline
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    This difference was insignificant in cases younger than 35 years (p < 0.594).
    4 context sentences
    Summary · context
    Spontaneous menstrual reverse occurred in 90.5% of patients receiving diphereline at three to six months after treatment which occurred in 33.3% of control cases.
    Summary · context
    This randomized clinical trial (RCT) was conducted on 42 adenocarcinoma cases.
    Summary · context
    Primary stages to Stage II (T2N1M0) whose histology reports were negative ER/PR were enrolled in this study.
    Summary · context
    All the enrolled patients were candidates for cyclophosphamide (600 mg/m2), adriamycin (60 mg/m2), and taxoter (75 mg/m2) chemotherapy regimens.
  6. 06HumanRandomized controlled trialEfficacy outcome

    In women with breast cancer older than 35 years, diphereline increased menstrual recovery versus chemotherapy controls within six months.

    In plain wordsWomen older than 35 had more menstrual recovery with diphereline than chemotherapy controls within six months.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    IncreaseMenstrual recovery above age 35
    Study

    n: not reported in source

    Comparator
    Chemotherapy without diphereline
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Measurements

    Menstrual recovery
    100%
    diphereline, older than 35
    Menstrual recovery
    20%
    controls, older than 35

    Source sentences

    Summary
    In 100% of patients older than 35 years who received diphereline, spontaneous menstrual reverse occurred during six months after chemotherapy, but this occurred in only 20% of controls (p < 0.001).
    3 context sentences
    Summary · context
    This randomized clinical trial (RCT) was conducted on 42 adenocarcinoma cases.
    Summary · context
    Primary stages to Stage II (T2N1M0) whose histology reports were negative ER/PR were enrolled in this study.
    Summary · context
    All the enrolled patients were candidates for cyclophosphamide (600 mg/m2), adriamycin (60 mg/m2), and taxoter (75 mg/m2) chemotherapy regimens.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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