Kisspeptin modulates fertilization capacity of mouse spermatozoa.

Hsu MC, Wang JY, Lee YJ, Jong DS, Tsui KH, Chiu CH

Reproduction (Cambridge, England)24 Feb 2014Cited by 53 (Europe PMC)

PMID24567427DOI10.1530/rep-13-0368PepBankPUB-24567427

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

1 result from studies that gave the peptide. No result from this study comes from people.

01LabEx vivo tissueMechanism
In Fluo-4-loaded mouse sperm, treatment with kisspeptin‑10 significantly increased intracellular calcium concentrations.
In plain wordsIn lab tests on mouse sperm, kisspeptin‑10 raised calcium levels inside the sperm.
Peptide
Kisspeptin-10
Outcome
IncreaseSperm intracellular calcium
Study
mousen: not reported in source
Fluo-4-loaded mouse sperm
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
The sperm intracellular calcium concentrations significantly increased in response to treatment with kisspeptin 10 in Fluo-4-loaded sperm.
1 context sentence(design, population, supporting numbers)
Summary · context
The purpose of this study was to investigate the expression profiles and functions of kisspeptin and KISS1R in the reproductive tissues of imprinting control region mice.
Report a problemFND-2456742703

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

02AnimalEndogenous levelAnimal study (in vivo)Other
In imprinting control region mice, the body's own kisspeptin was expressed primarily in testicular Leydig cells.
In plain wordsIn mice, the body's own kisspeptin was found mainly in Leydig cells of the testis.
Peptide
Kisspeptin-10
Outcome
Not applicableKisspeptin expression in testis
Study
mousen: not reported in source
imprinting control region mouse gonads
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
Kisspeptin and KISS1R were expressed primarily in Leydig cells and seminiferous tubules respectively.
1 context sentence(design, population, supporting numbers)
Summary · context
The purpose of this study was to investigate the expression profiles and functions of kisspeptin and KISS1R in the reproductive tissues of imprinting control region mice.
This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2456742701
03AnimalEndogenous levelAnimal study (in vivo)Other
In imprinting control region mice, the body's own kisspeptin was expressed in the cumulus-oocyte complex and oviductal epithelium.
In plain wordsIn mice, the body's own kisspeptin was found in egg-surrounding cells and the oviduct lining.
Peptide
Kisspeptin-10
Outcome
Not applicableKisspeptin expression in ovarian and oviductal tissue
Study
mousen: not reported in source
imprinting control region mouse ovarian and oviductal tissue
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
Kisspeptin, but not KISS1R, was expressed in the cumulus-oocyte complex and oviductal epithelium of ovarian and oviductal tissues.
1 context sentence(design, population, supporting numbers)
Summary · context
The purpose of this study was to investigate the expression profiles and functions of kisspeptin and KISS1R in the reproductive tissues of imprinting control region mice.
This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2456742702

Studies that did not test the peptide alone1

In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Kisspeptin-10.

04LabNot a test of Kisspeptin-10 aloneEx vivo tissueEfficacy outcome
In mouse in vitro fertilization, treating sperm with the kisspeptin antagonist peptide 234 decreased IVF rates.
In plain wordsIn lab tests with mouse sperm, a kisspeptin blocker lowered fertilization rates.
Peptide
Kisspeptin-10
Outcome
DecreaseIn vitro fertilization rate after kisspeptin antagonist peptide 234
Study
mousen: not reported in source
mouse sperm and oocytes (in vitro fertilization)
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
The IVF rates decreased after treatment of sperm with the kisspeptin antagonist peptide 234.
1 context sentence(design, population, supporting numbers)
Summary · context
The purpose of this study was to investigate the expression profiles and functions of kisspeptin and KISS1R in the reproductive tissues of imprinting control region mice.
In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.
Report a problemFND-2456742704

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 09:43 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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