The proton permeability of self-assembled polymersomes and their neuroprotection by enhancing a neuroprotective peptide across the blood-brain barrier after modification with lactoferrin.

Yu Y, Jiang X, Gong S, Feng L, Zhong Y, Pang Z

Nanoscale7 Feb 2014Cited by 35 (Europe PMC)

PMID24503971DOI10.1039/c3nr05196jPepBankPUB-24503971

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone5

In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Humanin.

01AnimalNot a test of Humanin aloneAnimal study (in vivo)Pharmacokinetics
Fluorescence imaging indicated that Lf101-POS was effectively transferred into the brain.
In plain wordsIn animals, imaging showed that the lactoferrin-coated polymersomes reached the brain.
Peptide
Humanin
Outcome
Not applicableBrain transfer of Lf101-POS by fluorescence imaging
Study
n: not reported in source
Outcome group
Pharmacokinetics · Pharmacology
Source sentences
Summary
Fluorescence imaging indicated that Lf101-POS was effectively transferred into the brain.
In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.
Report a problemFND-2450397102
02AnimalNot a test of Humanin aloneAnimal study (in vivo)Pharmacokinetics
Compared with transferrin-modified and cationic bovine serum albumin-modified polymersomes, Lf-POS obtained the greatest BBB permeability surface area and percentage of injected dose per gram.
In plain wordsIn animals, lactoferrin-coated polymersomes crossed into the brain better than polymersomes with transferrin or modified albumin.
Peptide
Humanin
Outcome
IncreaseBBB permeability surface area and %ID per g of Lf-POS
Study
n: not reported in source
Comparator
Transferrin-modified and cationic bovine serum albumin-modified polymersomes
Outcome group
Pharmacokinetics · Pharmacology
Source sentences
Summary
In pharmacokinetics, compared with transferrin-modified polymersomes and cationic bovine serum albumin-modified polymersomes, Lf-POS obtained the greatest BBB permeability surface area and percentage of injected dose per gram (%ID per g).
In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.
Report a problemFND-2450397103
03AnimalNot a test of Humanin aloneAnimal study (in vivo)Efficacy outcome
In rats, Lf-POS holding S14G-humanin protected against learning and memory impairment induced by amyloid-β25-35.
In plain wordsIn rats, lactoferrin-coated polymersomes carrying a humanin analog protected against memory problems caused by amyloid-β25-35.
Peptide
Humanin
Outcome
DecreaseLearning and memory impairment induced by Aβ25-35
Study
ratn: not reported in source
Aβ25-35-induced learning and memory impairment
Outcome group
Cognition and memory · Nervous system and cognition
Source sentences
Summary
Furthermore, Lf-POS holding S14G-humanin protected against learning and memory impairment induced by amyloid-β25-35 in rats.
In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.
Report a problemFND-2450397104
04LabNot a test of Humanin aloneIn vitro (cells)Other
Uptake of polymersomes by mouse brain capillary endothelial cells showed an optimal lactoferrin density of 101 molecules per polymersome.
In plain wordsIn mouse brain blood-vessel cells, polymersomes were taken up best at a set amount of lactoferrin on their surface.
Peptide
Humanin
Outcome
Not applicableOptimal lactoferrin density for polymersome uptake
Study
mousen: not reported in source
mouse brain capillary endothelial cells
Outcome group
Pharmacokinetics · Pharmacology
Measurements
Optimal lactoferrin density
101 molecules per polymersome
mouse brain capillary endothelial cells
Source sentences
Summary
The uptake of polymersomes by mouse brain capillary endothelial cells proved that the optimal density of lactoferrin was 101 molecules per polymersome.
In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.
Report a problemFND-2450397101
05LabNot a test of Humanin aloneIn vitro (cells)Mechanism
By western blotting, the nanomedicine provided neuroprotection against over-expression of apoptotic proteins in neurons.
In plain wordsIn neurons, the nanomedicine reduced the rise in cell-death proteins, according to western blots.
Peptide
Humanin
Outcome
DecreaseOver-expression of apoptotic proteins in neurons
Study
n: not reported in source
neurons
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
Western blotting revealed that the nanomedicine provided neuroprotection against over-expression of apoptotic proteins exhibiting neurofibrillary tangle pathology in neurons.
1 context sentence(design, population, supporting numbers)
Summary · context
Furthermore, Lf-POS holding S14G-humanin protected against learning and memory impairment induced by amyloid-β25-35 in rats.
In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.
Report a problemFND-2450397105

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.