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Study · Animal study (in vivo) · mouse · 2014

7 results

NAD(+) administration decreases doxorubicin-induced liver damage of mice by enhancing antioxidation capacity and decreasing DNA damage.

Wang B, Ma Y, Kong X, Ding X, Gu H, Chu T, Ying W

Chemico-biological interactions1 Feb 2014Cited by 35 (Europe PMC)

PMID24491677 (opens in a new tab)DOI10.1016/j.cbi.2014.01.013 (opens in a new tab)PepBankPUB-24491677
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice, NAD attenuated the DOX-induced increase in serum glutamate oxaloacetate transaminase activity.

    In plain wordsIn mice, NAD reduced the liver enzyme increase caused by DOX.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    DecreaseSerum glutamate oxaloacetate transaminase activity
    Study

    mousen: not reported in source

    DOX-induced hepatotoxicity
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In this study we tested this hypothesis by using a mouse model, showing that NAD(+) administration can significantly attenuate DOX-induced increase in serum glutamate oxaloacetate transaminase activity and decrease in liver weight.
    1 context sentence
    Summary · context
    In this study we tested this hypothesis by using a mouse model
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice, NAD attenuated the DOX-induced decrease in liver weight.

    In plain wordsIn mice, NAD reduced the loss of liver weight caused by DOX.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    IncreaseLiver weight
    Study

    mousen: not reported in source

    DOX-induced hepatotoxicity
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In this study we tested this hypothesis by using a mouse model, showing that NAD(+) administration can significantly attenuate DOX-induced increase in serum glutamate oxaloacetate transaminase activity and decrease in liver weight.
    1 context sentence
    Summary · context
    In this study we tested this hypothesis by using a mouse model
  3. 03AnimalAnimal study (in vivo)Mechanism

    In mice, NAD attenuated the DOX-induced increase in liver double-strand DNA damage.

    In plain wordsIn mice, NAD reduced the increase in liver DNA damage caused by DOX.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    DecreaseDouble-strand DNA damage
    Study

    mousen: not reported in source

    DOX-induced hepatotoxicity
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The NAD(+) administration also attenuated the DOX-induced increases in the levels of double-strand DNA (dsDNA) damage, TUNEL signals, and active caspase-3.
    1 context sentence
    Summary · context
    In this study we tested this hypothesis by using a mouse model
  4. 04AnimalAnimal study (in vivo)Mechanism

    In mice, NAD attenuated the DOX-induced increase in liver TUNEL signals.

    In plain wordsIn mice, NAD reduced the increase in liver TUNEL signals caused by DOX.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    DecreaseTUNEL signals
    Study

    mousen: not reported in source

    DOX-induced hepatotoxicity
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The NAD(+) administration also attenuated the DOX-induced increases in the levels of double-strand DNA (dsDNA) damage, TUNEL signals, and active caspase-3.
    1 context sentence
    Summary · context
    In this study we tested this hypothesis by using a mouse model
  5. 05AnimalAnimal study (in vivo)Mechanism

    In mice, NAD attenuated the DOX-induced increase in active caspase-3.

    In plain wordsIn mice, NAD reduced the increase in active caspase-3 caused by DOX.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    DecreaseActive caspase-3
    Study

    mousen: not reported in source

    DOX-induced hepatotoxicity
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The NAD(+) administration also attenuated the DOX-induced increases in the levels of double-strand DNA (dsDNA) damage, TUNEL signals, and active caspase-3.
    1 context sentence
    Summary · context
    In this study we tested this hypothesis by using a mouse model
  6. 06AnimalAnimal study (in vivo)Mechanism

    In mice, NAD attenuated the decrease in liver GSH levels caused by DOX.

    In plain wordsIn mice, NAD reduced the loss of liver GSH caused by DOX.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    IncreaseGSH levels
    Study

    mousen: not reported in source

    DOX-induced hepatotoxicity
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    because NAD(+) administration can attenuate the decreases in both the GSH levels and the glutathione reductase activity of the DOX-treated liver
    1 context sentence
    Summary · context
    In this study we tested this hypothesis by using a mouse model
  7. 07AnimalAnimal study (in vivo)Mechanism

    In mice, NAD attenuated the decrease in liver glutathione reductase activity caused by DOX.

    In plain wordsIn mice, NAD reduced the loss of liver glutathione reductase activity caused by DOX.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    IncreaseGlutathione reductase activity
    Study

    mousen: not reported in source

    DOX-induced hepatotoxicity
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    because NAD(+) administration can attenuate the decreases in both the GSH levels and the glutathione reductase activity of the DOX-treated liver
    1 context sentence
    Summary · context
    In this study we tested this hypothesis by using a mouse model

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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