In rats and mice, BPC‑157 given before challenge prevented anaphylactoid reactions after dextran and/or white egg, compared with saline controls.
In plain wordsIn rats and mice, BPC‑157 prevented allergy-like reactions to dextran or egg white, compared with saline.
- Peptide
- BPC-157
- Outcome
- DecreasePrevention of anaphylactoid reaction
- Study
rat, mousen: not reported in source
Anaphylactoid reaction after intravenous dextran and/or white egg- Comparator
- Saline controls
- Outcome group
- Immune response · Immune and inflammation
- Studied dose
- 10 µg/kg, 1 µg/kg, 10 ng/kg, 10 pg/kg · intraperitonealAs given in this study (rat, mouse).
Source sentences
BPC 157 regimens (10µg, 1µg, 10ng, and 10pg/kg) effectively, may both prevent anaphylactoid reactions that may arise from dextran and/or white egg application
2 context sentences(design, population, supporting numbers)
Anesthetized mice or rats received intravenously 6%, 10%, 20%, 40%, 60%, 80%, and 90% dextran and/or white egg (1ml/rat or 0.15ml/mouse) into their tails.
Medication (/kg b.w., 5ml/kg) was given intraperitoneally (BPC 157 10µg, 1µg, 10ng, and 10pg/kg, chloropyramine 20mg/kg, and cimetidine 10mg/kg intraperitoneally, alone or in combination while controls received an equivolume of saline), immediately after challenge or, alternatively, at 5min after or…