Effects of carnosine on cyclophosphamide-induced hematopoietic suppression in mice.

Xu M, He RR, Zhai YJ, Abe K, Kurihara H

The American journal of Chinese medicine1 Jan 2014Cited by 25 (Europe PMC)

PMID24467540DOI10.1142/s0192415x14500098PepBankPUB-24467540

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In cyclophosphamide-treated mice, carnosine improved suppressed hematopoietic functions.
In plain wordsIn mice treated with cyclophosphamide, carnosine improved blood cell production.
Peptide
L-carnosine
Outcome
IncreaseHematopoietic function
Study
micen: not reported in source
cyclophosphamide-induced hematopoietic suppression
Outcome group
Immune response · Immune and inflammation
Studied dose
100 mg/kg/day or 200 mg/kg/day · seven daysAs given in this study (mice).
Source sentences
Summary
We further showed that carnosine administration (100 mg/kg/day or 200 mg/kg/day for continuous seven days) could substantially improve suppressed hematopoietic functions
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, we investigated the effects of carnosine on hematopoietic suppression in mice treated with cyclophosphamide.
Report a problemFND-2446754001
02AnimalAnimal study (in vivo)Efficacy outcome
In cyclophosphamide-treated mice, carnosine accelerated leukocyte count recovery.
In plain wordsIn mice treated with cyclophosphamide, carnosine accelerated white blood cell recovery.
Peptide
L-carnosine
Outcome
IncreaseLeukocyte count recovery
Study
micen: not reported in source
cyclophosphamide-induced hematopoietic suppression
Outcome group
Immune response · Immune and inflammation
Studied dose
100 mg/kg/day or 200 mg/kg/day · seven daysAs given in this study (mice).
Source sentences
Summary
and accelerate the recovery of leukocyte counts, bone marrow spontaneous proliferation, colony stimulating activity (CSA) in serum, and production of endogenous cytokines such as interleukin-3 (IL-3) and stem cell factor (SCF).
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, we investigated the effects of carnosine on hematopoietic suppression in mice treated with cyclophosphamide.
Report a problemFND-2446754002
03AnimalAnimal study (in vivo)Efficacy outcome
In cyclophosphamide-treated mice, carnosine accelerated recovery of spontaneous bone marrow proliferation.
In plain wordsIn mice treated with cyclophosphamide, carnosine accelerated recovery of bone marrow cell growth.
Peptide
L-carnosine
Outcome
IncreaseBone marrow spontaneous proliferation
Study
micen: not reported in source
cyclophosphamide-induced hematopoietic suppression
Outcome group
Immune response · Immune and inflammation
Studied dose
100 mg/kg/day or 200 mg/kg/day · seven daysAs given in this study (mice).
Source sentences
Summary
and accelerate the recovery of leukocyte counts, bone marrow spontaneous proliferation, colony stimulating activity (CSA) in serum, and production of endogenous cytokines such as interleukin-3 (IL-3) and stem cell factor (SCF).
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, we investigated the effects of carnosine on hematopoietic suppression in mice treated with cyclophosphamide.
Report a problemFND-2446754003
04AnimalAnimal study (in vivo)Efficacy outcome
In cyclophosphamide-treated mice, carnosine accelerated recovery of serum colony stimulating activity.
In plain wordsIn mice treated with cyclophosphamide, carnosine improved recovery of serum activity that supports blood cell production.
Peptide
L-carnosine
Outcome
IncreaseSerum colony stimulating activity
Study
micen: not reported in source
cyclophosphamide-induced hematopoietic suppression
Outcome group
Immune response · Immune and inflammation
Studied dose
100 mg/kg/day or 200 mg/kg/day · seven daysAs given in this study (mice).
Source sentences
Summary
and accelerate the recovery of leukocyte counts, bone marrow spontaneous proliferation, colony stimulating activity (CSA) in serum, and production of endogenous cytokines such as interleukin-3 (IL-3) and stem cell factor (SCF).
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, we investigated the effects of carnosine on hematopoietic suppression in mice treated with cyclophosphamide.
Report a problemFND-2446754004
05AnimalAnimal study (in vivo)Efficacy outcome
In cyclophosphamide-treated mice, carnosine accelerated recovery of endogenous interleukin-3 production.
In plain wordsIn mice treated with cyclophosphamide, carnosine accelerated recovery of interleukin-3 production.
Peptide
L-carnosine
Outcome
IncreaseInterleukin-3 production
Study
micen: not reported in source
cyclophosphamide-induced hematopoietic suppression
Outcome group
Immune response · Immune and inflammation
Studied dose
100 mg/kg/day or 200 mg/kg/day · seven daysAs given in this study (mice).
Source sentences
Summary
and accelerate the recovery of leukocyte counts, bone marrow spontaneous proliferation, colony stimulating activity (CSA) in serum, and production of endogenous cytokines such as interleukin-3 (IL-3) and stem cell factor (SCF).
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, we investigated the effects of carnosine on hematopoietic suppression in mice treated with cyclophosphamide.
Report a problemFND-2446754005
06AnimalAnimal study (in vivo)Efficacy outcome
In cyclophosphamide-treated mice, carnosine accelerated recovery of endogenous stem cell factor production.
In plain wordsIn mice treated with cyclophosphamide, carnosine accelerated recovery of stem cell factor production.
Peptide
L-carnosine
Outcome
IncreaseStem cell factor production
Study
micen: not reported in source
cyclophosphamide-induced hematopoietic suppression
Outcome group
Immune response · Immune and inflammation
Studied dose
100 mg/kg/day or 200 mg/kg/day · seven daysAs given in this study (mice).
Source sentences
Summary
and accelerate the recovery of leukocyte counts, bone marrow spontaneous proliferation, colony stimulating activity (CSA) in serum, and production of endogenous cytokines such as interleukin-3 (IL-3) and stem cell factor (SCF).
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, we investigated the effects of carnosine on hematopoietic suppression in mice treated with cyclophosphamide.
Report a problemFND-2446754006

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
27 Oct 2026, 18:20 UTC
Study results updated
Version 1
27 Oct 2026, 16:32 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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