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Study · Animal study (in vivo) · rat · 2014

5 results

Treatment with carnosine reduces hypoxia-ischemia brain damage in a neonatal rat model.

Zhang H, Guo S, Zhang L, Jia L, Zhang Z, Duan H, Zhang J, Liu J, Zhang W

European journal of pharmacology23 Jan 2014Cited by 14 (Europe PMC)

PMID24463179 (opens in a new tab)DOI10.1016/j.ejphar.2014.01.023 (opens in a new tab)PepBankPUB-24463179
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In neonatal rats after hypoxia-ischemia, carnosine significantly reduced brain 8-iso-prostaglandinF2alpha concentration.

    In plain wordsIn rats with brain injury, carnosine reduced a marker of oxidative stress.

    Peptide
    L-carnosine
    Outcome
    DecreaseBrain 8-iso-prostaglandinF2alpha
    Study

    ratsn: not reported in source

    neonatal hypoxia-ischemia brain damage
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    250mg/kg · intraperitoneal · 0h, 24h, and 48h after hypoxia-ischemiaAs given in this study (rats).

    Source sentences

    Summary
    Treatment with carnosine post-HIBD significantly reduced the concentration of 8-iso-prostaglandinF2alpha in brain tissue and decreased the number of terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) positive cells in the hippocampus CA1 region and cortex as well as the mitochondri…
    2 context sentences
    Summary · context
    Hypoxia-ischemia was induced in rats on postnatal days 7-9 (P7-9).
    Summary · context
    Carnosine was administered intraperitoneally at a dose of 250mg/kg at 0h, 24h, and 48h after hypoxia-ischemia was induced.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In neonatal rats after hypoxia-ischemia, carnosine decreased TUNEL-positive cells in hippocampal CA1.

    In plain wordsIn rats with brain injury, carnosine decreased dying cells in the hippocampus.

    Peptide
    L-carnosine
    Outcome
    DecreaseHippocampal CA1 TUNEL-positive cells
    Study

    ratsn: not reported in source

    neonatal hypoxia-ischemia brain damage
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    250mg/kg · intraperitoneal · 0h, 24h, and 48h after hypoxia-ischemiaAs given in this study (rats).

    Source sentences

    Summary
    Treatment with carnosine post-HIBD significantly reduced the concentration of 8-iso-prostaglandinF2alpha in brain tissue and decreased the number of terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) positive cells in the hippocampus CA1 region and cortex as well as the mitochondri…
    2 context sentences
    Summary · context
    Hypoxia-ischemia was induced in rats on postnatal days 7-9 (P7-9).
    Summary · context
    Carnosine was administered intraperitoneally at a dose of 250mg/kg at 0h, 24h, and 48h after hypoxia-ischemia was induced.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In neonatal rats after hypoxia-ischemia, carnosine decreased cortical TUNEL-positive cells.

    In plain wordsIn rats with brain injury, carnosine decreased dying cells in the cortex.

    Peptide
    L-carnosine
    Outcome
    DecreaseCortical TUNEL-positive cells
    Study

    ratsn: not reported in source

    neonatal hypoxia-ischemia brain damage
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    250mg/kg · intraperitoneal · 0h, 24h, and 48h after hypoxia-ischemiaAs given in this study (rats).

    Source sentences

    Summary
    Treatment with carnosine post-HIBD significantly reduced the concentration of 8-iso-prostaglandinF2alpha in brain tissue and decreased the number of terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) positive cells in the hippocampus CA1 region and cortex as well as the mitochondri…
    2 context sentences
    Summary · context
    Hypoxia-ischemia was induced in rats on postnatal days 7-9 (P7-9).
    Summary · context
    Carnosine was administered intraperitoneally at a dose of 250mg/kg at 0h, 24h, and 48h after hypoxia-ischemia was induced.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In neonatal rats after hypoxia-ischemia, carnosine decreased mitochondrial caspase-3 protein expression.

    In plain wordsIn rats with brain injury, carnosine decreased a protein involved in cell death.

    Peptide
    L-carnosine
    Outcome
    DecreaseMitochondrial caspase-3 expression
    Study

    ratsn: not reported in source

    neonatal hypoxia-ischemia brain damage
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    250mg/kg · intraperitoneal · 0h, 24h, and 48h after hypoxia-ischemiaAs given in this study (rats).

    Source sentences

    Summary
    Treatment with carnosine post-HIBD significantly reduced the concentration of 8-iso-prostaglandinF2alpha in brain tissue and decreased the number of terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) positive cells in the hippocampus CA1 region and cortex as well as the mitochondri…
    2 context sentences
    Summary · context
    Hypoxia-ischemia was induced in rats on postnatal days 7-9 (P7-9).
    Summary · context
    Carnosine was administered intraperitoneally at a dose of 250mg/kg at 0h, 24h, and 48h after hypoxia-ischemia was induced.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats with hypoxia-ischemia brain damage, carnosine improved cognitive function at P28-33.

    In plain wordsIn rats with brain injury, carnosine improved cognitive function.

    Peptide
    L-carnosine
    Outcome
    IncreaseCognitive function
    Study

    ratsn: not reported in source

    neonatal hypoxia-ischemia brain damage
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    250mg/kg · intraperitoneal · 0h, 24h, and 48h after hypoxia-ischemiaAs given in this study (rats).

    Source sentences

    Summary
    Furthermore, carnosine also improved the cognitive function of P28-33 rats, whose cognitive function decline was due to HIBD.
    2 context sentences
    Summary · context
    Hypoxia-ischemia was induced in rats on postnatal days 7-9 (P7-9).
    Summary · context
    Carnosine was administered intraperitoneally at a dose of 250mg/kg at 0h, 24h, and 48h after hypoxia-ischemia was induced.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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