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Study · Observational study · n = 30 · 2014

4 results

Resumption of puberty in girls and boys following removal of the histrelin implant.

Fisher MM, Lemay D, Eugster EA

The Journal of pediatrics14 Jan 2014Cited by 16 (Europe PMC)

PMID24433825 (opens in a new tab)PMCIDPMC4096830 (opens in a new tab)DOI10.1016/j.jpeds.2013.12.009 (opens in a new tab)PepBankPUB-24433825
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanObservational studyEfficacy outcome

    Among girls treated with histrelin for central precocious puberty, 26 reached menarche at an average of 12.75 months after explantation.

    In plain wordsAmong girls treated with histrelin for central precocious puberty, 26 reached menarche an average of 12.75 months after implant removal.

    Peptide
    Histrelin
    Outcome
    Not applicableMenarche after explantation in CPP
    Study

    n = 30

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Measurements

    Girls with menarche after explantation
    26 girls
    of 30 treated for CPP
    Time to menarche after explantation
    12.75 months
    average, girls with CPP who had menarche

    Source sentences

    Summary
    Of the girls, 30 were treated for central precocious puberty (CPP), 26 had menarche at an average of 12.75 months after explantation.
    2 context sentences
    Summary · context
    Medical records of patients treated with a histrelin implant were reviewed.
    Summary · context
    Seventy-one patients (56 girls) treated with the histrelin implant were identified, of these patients, 37 explanted girls (68% naïve) and 6 explanted boys (83% naïve) were included in the analysis.
  2. 02HumanObservational studyEfficacy outcome

    Among girls treated with histrelin for other indications, 6 of 7 had reached menarche.

    In plain wordsAmong girls treated with histrelin for other indications, 6 of 7 had reached menarche.

    Peptide
    Histrelin
    Outcome
    Not applicableMenarche after treatment for other indications
    Study

    n = 7

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Measurements

    Girls who had reached menarche
    6 girls
    of 7 treated for other indications

    Source sentences

    Summary
    Of the 30, 7 were treated for other indications, of whom 6 had reached menarche.
    2 context sentences
    Summary · context
    Medical records of patients treated with a histrelin implant were reviewed.
    Summary · context
    Seventy-one patients (56 girls) treated with the histrelin implant were identified, of these patients, 37 explanted girls (68% naïve) and 6 explanted boys (83% naïve) were included in the analysis.
  3. 03HumanObservational studyEfficacy outcome

    All boys treated with histrelin achieved spontaneous testicular enlargement within 1 year after explantation.

    In plain wordsAll boys treated with histrelin had spontaneous testicular enlargement within 1 year after implant removal.

    Peptide
    Histrelin
    Outcome
    Not applicableSpontaneous testicular enlargement after explantation
    Study

    n = 6

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Measurements

    Time to testicular enlargement after explantation
    ≤ 1 year
    all 6 boys, within this time

    Source sentences

    Summary
    All boys achieved spontaneous testicular enlargement within 1 year of explantation.
    2 context sentences
    Summary · context
    Medical records of patients treated with a histrelin implant were reviewed.
    Summary · context
    Seventy-one patients (56 girls) treated with the histrelin implant were identified, of these patients, 37 explanted girls (68% naïve) and 6 explanted boys (83% naïve) were included in the analysis.
  4. 04HumanObservational studyEfficacy outcome

    In girls treated with histrelin for CPP, older age at explantation correlated with sooner menarche (P = .04).

    In plain wordsIn girls treated with histrelin for CPP, older age at implant removal was linked to sooner menarche.

    Peptide
    Histrelin
    Outcome
    DecreaseAge at explantation and time to menarche
    Study

    n: not reported in source

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In girls with CPP, older age at explantation correlated with sooner menarche (P = .04).
    2 context sentences
    Summary · context
    Medical records of patients treated with a histrelin implant were reviewed.
    Summary · context
    Seventy-one patients (56 girls) treated with the histrelin implant were identified, of these patients, 37 explanted girls (68% naïve) and 6 explanted boys (83% naïve) were included in the analysis.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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