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Study · Animal study (in vivo) · horse · 2014

4 results

Acute injection and chronic perfusion of kisspeptin elicit gonadotropins release but fail to trigger ovulation in the mare.

Decourt C, Caraty A, Briant C, Guillaume D, Lomet D, Chesneau D, Lardic L, Duchamp G, Reigner F, Monget P, Dufourny L, Beltramo M, Dardente H

Biology of reproduction20 Feb 2014Cited by 16 (Europe PMC)

PMID24429215 (opens in a new tab)DOI10.1095/biolreprod.113.114157 (opens in a new tab)PepBankPUB-24429215
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In Welsh pony mares, intravenous equine kisspeptin‑10 reliably increased peripheral luteinizing hormone concentrations in all experimental conditions.

    In plain wordsIn pony mares, kisspeptin‑10 reliably raised blood levels of luteinizing hormone in all conditions tested.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseLuteinizing hormone concentration
    Study

    horsen: not reported in source

    Welsh pony mares
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated · intravenousAs given in this study (horse).

    Source sentences

    Summary
    In all the experimental conditions, eKp10 reliably increased peripheral concentrations of both luteinizing hormone and follicle-stimulating hormone.
    1 context sentence
    Summary · context
    Equine kisspeptin-10 (eKp10) was administered intravenously as bolus injections or short- to long-term perfusions to Welsh pony mares, either during the anestrus season or at various stages of the cycle during the breeding season.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In Welsh pony mares, intravenous equine kisspeptin‑10 reliably increased peripheral follicle-stimulating hormone concentrations in all experimental conditions.

    In plain wordsIn pony mares, kisspeptin‑10 reliably raised blood levels of follicle-stimulating hormone in all conditions tested.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseFollicle-stimulating hormone concentration
    Study

    horsen: not reported in source

    Welsh pony mares
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated · intravenousAs given in this study (horse).

    Source sentences

    Summary
    In all the experimental conditions, eKp10 reliably increased peripheral concentrations of both luteinizing hormone and follicle-stimulating hormone.
    1 context sentence
    Summary · context
    Equine kisspeptin-10 (eKp10) was administered intravenously as bolus injections or short- to long-term perfusions to Welsh pony mares, either during the anestrus season or at various stages of the cycle during the breeding season.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In Welsh pony mares, the gonadotropin rise after equine kisspeptin‑10 was rapid and essentially transient, even during prolonged perfusion.

    In plain wordsIn pony mares, the hormone rise after kisspeptin‑10 was fast and short-lived, even when the peptide was infused for a long time.

    Peptide
    Kisspeptin-10
    Outcome
    Not applicableDuration of gonadotropin rise during prolonged perfusion
    Study

    horsen: not reported in source

    Welsh pony mares
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated · intravenousAs given in this study (horse).

    Source sentences

    Summary
    The nature of the response to eKp10 was consistent across experimental conditions and physiological states: the increase in gonadotropins was always rapid and essentially transient even when eKp10 was perfused for prolonged periods.
    1 context sentence
    Summary · context
    Equine kisspeptin-10 (eKp10) was administered intravenously as bolus injections or short- to long-term perfusions to Welsh pony mares, either during the anestrus season or at various stages of the cycle during the breeding season.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In Welsh pony mares, equine kisspeptin‑10 consistently failed to induce ovulation.

    In plain wordsIn pony mares, kisspeptin‑10 did not trigger ovulation.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeOvulation induction
    Study

    horsen: not reported in source

    Welsh pony mares
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · intravenousAs given in this study (horse).

    Source sentences

    Summary
    Furthermore, eKp10 consistently failed to induce ovulation in the mare.
    1 context sentence
    Summary · context
    Equine kisspeptin-10 (eKp10) was administered intravenously as bolus injections or short- to long-term perfusions to Welsh pony mares, either during the anestrus season or at various stages of the cycle during the breeding season.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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