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Study · Animal study (in vivo) · pig · 2014

4 results

Acute effects of the glucagon-like peptide 2 analogue, teduglutide, on intestinal adaptation in short bowel syndrome.

Thymann T, Stoll B, Mecklenburg L, Burrin DG, Vegge A, Qvist N, Eriksen T, Jeppesen PB, Sangild PT

Journal of pediatric gastroenterology and nutrition1 Jun 2014Cited by 38 (Europe PMC)

PMID24399211 (opens in a new tab)DOI10.1097/mpg.0000000000000295 (opens in a new tab)PepBankPUB-24399211
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In piglets with jejunostomy, teduglutide 0.2 mg · kg · day increased intestinal fractional protein synthesis versus placebo (P < 0.001).

    In plain wordsIn piglets with jejunostomy, the highest teduglutide dose increased intestinal protein synthesis versus placebo.

    Peptide
    Teduglutide
    Outcome
    IncreaseIntestinal fractional protein synthesis
    Study

    pign = 15

    Neonatal piglet jejunostomy after 50% distal small-intestine resection
    Comparator
    Placebo
    Outcome group
    Intestinal adaptation · Gastrointestinal
    Studied dose
    0.2 mg · kg · day · 7 daysAs given in this study (pig).

    Source sentences

    Summary
    and fractional protein synthesis rate in the intestine was increased in the 0.2 mg · kg · day group versus placebo (P < 0.001)
    3 context sentences
    Summary · context
    Our objective was to test the efficacy of the long-acting synthetic human GLP-2 analogue, teduglutide (ALX-0600), in a neonatal piglet jejunostomy model.
    Summary · context
    Two-day-old pigs were subjected to resection of 50% of the small intestine (distal part), and the remnant intestine was exteriorized on the abdominal wall as a jejunostomy.
    Summary · context
    All pigs were given total parenteral nutrition for 7 days and a single daily injection of the following doses of teduglutide: 0.01 (n = 6), 0.02 (n = 6), 0.1 (n = 5), or 0.2 mg · kg · day (n = 6), and compared with placebo (n = 9).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In piglets with jejunostomy, body weight increment was similar across all four teduglutide groups and higher than placebo (P < 0.05).

    In plain wordsIn piglets with jejunostomy, teduglutide increased body weight more than placebo, with similar increments across the tested doses.

    Peptide
    Teduglutide
    Outcome
    IncreaseBody weight increment
    Study

    pign: not reported in source

    Neonatal piglet jejunostomy after 50% distal small-intestine resection
    Comparator
    Placebo
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    0.01, 0.02, 0.1, or 0.2 mg · kg · day · 7 daysAs given in this study (pig).

    Source sentences

    Summary
    Body weight increment was similar for all 4 teduglutide groups but higher than placebo (P < 0.05).
    3 context sentences
    Summary · context
    Our objective was to test the efficacy of the long-acting synthetic human GLP-2 analogue, teduglutide (ALX-0600), in a neonatal piglet jejunostomy model.
    Summary · context
    Two-day-old pigs were subjected to resection of 50% of the small intestine (distal part), and the remnant intestine was exteriorized on the abdominal wall as a jejunostomy.
    Summary · context
    All pigs were given total parenteral nutrition for 7 days and a single daily injection of the following doses of teduglutide: 0.01 (n = 6), 0.02 (n = 6), 0.1 (n = 5), or 0.2 mg · kg · day (n = 6), and compared with placebo (n = 9).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In piglets with jejunostomy, teduglutide produced a dose-dependent increase in remnant intestinal weight per length (P < 0.01).

    In plain wordsIn piglets with jejunostomy, teduglutide increased remnant intestinal weight per length with increasing dose.

    Peptide
    Teduglutide
    Outcome
    IncreaseRemnant intestinal weight per length
    Study

    pign: not reported in source

    Neonatal piglet jejunostomy after 50% distal small-intestine resection
    Comparator
    Placebo
    Outcome group
    Intestinal adaptation · Gastrointestinal
    Studied dose
    0.01, 0.02, 0.1, or 0.2 mg · kg · day · 7 daysAs given in this study (pig).

    Source sentences

    Summary
    There was a dose-dependent increase in weight per length of the remnant intestine (P < 0.01)
    3 context sentences
    Summary · context
    Our objective was to test the efficacy of the long-acting synthetic human GLP-2 analogue, teduglutide (ALX-0600), in a neonatal piglet jejunostomy model.
    Summary · context
    Two-day-old pigs were subjected to resection of 50% of the small intestine (distal part), and the remnant intestine was exteriorized on the abdominal wall as a jejunostomy.
    Summary · context
    All pigs were given total parenteral nutrition for 7 days and a single daily injection of the following doses of teduglutide: 0.01 (n = 6), 0.02 (n = 6), 0.1 (n = 5), or 0.2 mg · kg · day (n = 6), and compared with placebo (n = 9).
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In piglets with jejunostomy, teduglutide did not affect digestive enzyme activity, enteral nutrient absorption or immunohistochemical endpoints versus placebo.

    In plain wordsIn piglets with jejunostomy, teduglutide did not affect digestive enzymes, nutrient absorption or intestinal tissue markers versus placebo.

    Peptide
    Teduglutide
    Outcome
    No significant changeFunctional and structural intestinal endpoints
    Study

    pign: not reported in source

    Neonatal piglet jejunostomy after 50% distal small-intestine resection
    Comparator
    Placebo
    Outcome group
    Intestinal growth and absorption · Gastrointestinal
    Studied dose
    0.01, 0.02, 0.1, or 0.2 mg · kg · day · 7 daysAs given in this study (pig).

    Source sentences

    Summary
    however, functional and structural endpoints including activity of digestive enzymes, absorption of enteral nutrients, and immunohistochemistry (Ki67, villin, FABP2, ChgA, and GLP-2R) were not affected by the treatment.
    3 context sentences
    Summary · context
    Our objective was to test the efficacy of the long-acting synthetic human GLP-2 analogue, teduglutide (ALX-0600), in a neonatal piglet jejunostomy model.
    Summary · context
    Two-day-old pigs were subjected to resection of 50% of the small intestine (distal part), and the remnant intestine was exteriorized on the abdominal wall as a jejunostomy.
    Summary · context
    All pigs were given total parenteral nutrition for 7 days and a single daily injection of the following doses of teduglutide: 0.01 (n = 6), 0.02 (n = 6), 0.1 (n = 5), or 0.2 mg · kg · day (n = 6), and compared with placebo (n = 9).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:37 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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