Mechanism of the beneficial and protective effects of exenatide in diabetic rats.

Lotfy M, Singh J, Rashed H, Tariq S, Zilahi E, Adeghate E

The Journal of endocrinology10 Feb 2014Cited by 40 (Europe PMC)

PMID24353307DOI10.1530/joe-13-0426PepBankPUB-24353307

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study17

17 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In control and diabetic rats, exenatide increased pancreatic duodenal homeobox-1 gene expression versus untreated animals.
In plain wordsIn rats with and without diabetes, exenatide increased pancreatic duodenal homeobox-1 gene expression compared with untreated animals.
Peptide
Exenatide (exendin-4)
Outcome
IncreasePancreatic duodenal homeobox-1 expression
Study
ratn = 40
Streptozotocin-induced diabetes
Comparator
Untreated controls
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
1 μg/kg body weight · 10 weeksAs given in this study (rat).
Source sentences
Summary
Exenatide caused significant elevation in the expressions of pancreatic duodenal homeobox-1, heat shock protein-70, glutathione peroxidase, insulin receptor and GLP1 receptor genes in the pancreas of both control and diabetic rats compared with untreated animals.
2 context sentences(design, population, supporting numbers)
Summary · context
This study examines the mechanism of the protective effects of exenatide in experimental diabetes, employing four groups of ten rats each, in which two groups were streptozotocin-induced diabetic and two were control groups.
Summary · context
One control and one diabetic group were treated with exenatide (1 μg/kg body weight (BW)) for 10 weeks.
Report a problemFND-2435330713
02AnimalAnimal study (in vivo)Mechanism
In control and diabetic rats, exenatide increased pancreatic heat shock protein-70 gene expression versus untreated animals.
In plain wordsIn rats with and without diabetes, exenatide increased pancreatic heat shock protein-70 gene expression compared with untreated animals.
Peptide
Exenatide (exendin-4)
Outcome
IncreaseHeat shock protein-70 expression
Study
ratn = 40
Streptozotocin-induced diabetes
Comparator
Untreated controls
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
1 μg/kg body weight · 10 weeksAs given in this study (rat).
Source sentences
Summary
Exenatide caused significant elevation in the expressions of pancreatic duodenal homeobox-1, heat shock protein-70, glutathione peroxidase, insulin receptor and GLP1 receptor genes in the pancreas of both control and diabetic rats compared with untreated animals.
2 context sentences(design, population, supporting numbers)
Summary · context
This study examines the mechanism of the protective effects of exenatide in experimental diabetes, employing four groups of ten rats each, in which two groups were streptozotocin-induced diabetic and two were control groups.
Summary · context
One control and one diabetic group were treated with exenatide (1 μg/kg body weight (BW)) for 10 weeks.
Report a problemFND-2435330714
03AnimalAnimal study (in vivo)Mechanism
In control and diabetic rats, exenatide increased pancreatic glutathione peroxidase gene expression versus untreated animals.
In plain wordsIn rats with and without diabetes, exenatide increased pancreatic glutathione peroxidase gene expression compared with untreated animals.
Peptide
Exenatide (exendin-4)
Outcome
IncreaseGlutathione peroxidase expression
Study
ratn = 40
Streptozotocin-induced diabetes
Comparator
Untreated controls
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
1 μg/kg body weight · 10 weeksAs given in this study (rat).
Source sentences
Summary
Exenatide caused significant elevation in the expressions of pancreatic duodenal homeobox-1, heat shock protein-70, glutathione peroxidase, insulin receptor and GLP1 receptor genes in the pancreas of both control and diabetic rats compared with untreated animals.
2 context sentences(design, population, supporting numbers)
Summary · context
This study examines the mechanism of the protective effects of exenatide in experimental diabetes, employing four groups of ten rats each, in which two groups were streptozotocin-induced diabetic and two were control groups.
Summary · context
One control and one diabetic group were treated with exenatide (1 μg/kg body weight (BW)) for 10 weeks.
Report a problemFND-2435330715
04AnimalAnimal study (in vivo)Mechanism
In control and diabetic rats, exenatide increased pancreatic insulin receptor gene expression versus untreated animals.
In plain wordsIn rats with and without diabetes, exenatide increased pancreatic insulin receptor gene expression compared with untreated animals.
Peptide
Exenatide (exendin-4)
Outcome
IncreaseInsulin receptor expression
Study
ratn = 40
Streptozotocin-induced diabetes
Comparator
Untreated controls
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
1 μg/kg body weight · 10 weeksAs given in this study (rat).
Source sentences
Summary
Exenatide caused significant elevation in the expressions of pancreatic duodenal homeobox-1, heat shock protein-70, glutathione peroxidase, insulin receptor and GLP1 receptor genes in the pancreas of both control and diabetic rats compared with untreated animals.
2 context sentences(design, population, supporting numbers)
Summary · context
This study examines the mechanism of the protective effects of exenatide in experimental diabetes, employing four groups of ten rats each, in which two groups were streptozotocin-induced diabetic and two were control groups.
Summary · context
One control and one diabetic group were treated with exenatide (1 μg/kg body weight (BW)) for 10 weeks.
Report a problemFND-2435330716
05AnimalAnimal study (in vivo)Mechanism
In control and diabetic rats, exenatide increased pancreatic GLP1 receptor gene expression versus untreated animals.
In plain wordsIn rats with and without diabetes, exenatide increased pancreatic GLP1 receptor gene expression compared with untreated animals.
Peptide
Exenatide (exendin-4)
Outcome
IncreaseGLP1 receptor expression
Study
ratn = 40
Streptozotocin-induced diabetes
Comparator
Untreated controls
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
1 μg/kg body weight · 10 weeksAs given in this study (rat).
Source sentences
Summary
Exenatide caused significant elevation in the expressions of pancreatic duodenal homeobox-1, heat shock protein-70, glutathione peroxidase, insulin receptor and GLP1 receptor genes in the pancreas of both control and diabetic rats compared with untreated animals.
2 context sentences(design, population, supporting numbers)
Summary · context
This study examines the mechanism of the protective effects of exenatide in experimental diabetes, employing four groups of ten rats each, in which two groups were streptozotocin-induced diabetic and two were control groups.
Summary · context
One control and one diabetic group were treated with exenatide (1 μg/kg body weight (BW)) for 10 weeks.
Report a problemFND-2435330717
06AnimalAnimal study (in vivo)Efficacy outcome
In diabetic rats, exenatide improved body weight gain compared with controls.
In plain wordsIn rats with diabetes, exenatide improved weight gain compared with controls.
Peptide
Exenatide (exendin-4)
Outcome
IncreaseBody weight gain
Study
ratn: not reported in source
Streptozotocin-induced diabetes
Comparator
Untreated controls
Outcome group
Body weight · Metabolic and weight
Studied dose
1 μg/kg body weight · 10 weeksAs given in this study (rat).
Source sentences
Summary
The results show that exenatide improved BW gain and reduced blood glucose in diabetic rats compared with controls.
2 context sentences(design, population, supporting numbers)
Summary · context
This study examines the mechanism of the protective effects of exenatide in experimental diabetes, employing four groups of ten rats each, in which two groups were streptozotocin-induced diabetic and two were control groups.
Summary · context
One control and one diabetic group were treated with exenatide (1 μg/kg body weight (BW)) for 10 weeks.
Report a problemFND-2435330701
07AnimalAnimal study (in vivo)Efficacy outcome
In diabetic rats, exenatide reduced blood glucose compared with controls.
In plain wordsIn rats with diabetes, exenatide lowered blood glucose compared with controls.
Peptide
Exenatide (exendin-4)
Outcome
DecreaseBlood glucose
Study
ratn: not reported in source
Streptozotocin-induced diabetes
Comparator
Untreated controls
Outcome group
Glycemic control · Metabolic and weight
Studied dose
1 μg/kg body weight · 10 weeksAs given in this study (rat).
Source sentences
Summary
The results show that exenatide improved BW gain and reduced blood glucose in diabetic rats compared with controls.
2 context sentences(design, population, supporting numbers)
Summary · context
This study examines the mechanism of the protective effects of exenatide in experimental diabetes, employing four groups of ten rats each, in which two groups were streptozotocin-induced diabetic and two were control groups.
Summary · context
One control and one diabetic group were treated with exenatide (1 μg/kg body weight (BW)) for 10 weeks.
Report a problemFND-2435330702
08AnimalAnimal study (in vivo)Mechanism
In pancreatic fragments from diabetic rats, exenatide enhanced insulin release compared with controls.
In plain wordsIn rats with diabetes, exenatide treatment increased insulin release measured in pancreatic fragments compared with controls.
Peptide
Exenatide (exendin-4)
Outcome
IncreasePancreatic insulin release
Study
ratn: not reported in source
Streptozotocin-induced diabetes
Comparator
Untreated controls
Outcome group
Glycemic control · Endocrine and hormones
Studied dose
1 μg/kg body weight · 10 weeksAs given in this study (rat).
Source sentences
Summary
Similarly, exenatide enhanced insulin release from the pancreatic fragments and improved liver and kidney functions and lipid profile in diabetic rats compared with controls.
2 context sentences(design, population, supporting numbers)
Summary · context
This study examines the mechanism of the protective effects of exenatide in experimental diabetes, employing four groups of ten rats each, in which two groups were streptozotocin-induced diabetic and two were control groups.
Summary · context
One control and one diabetic group were treated with exenatide (1 μg/kg body weight (BW)) for 10 weeks.
Report a problemFND-2435330703
09AnimalAnimal study (in vivo)Efficacy outcome
In diabetic rats, exenatide improved liver function compared with controls.
In plain wordsIn rats with diabetes, exenatide improved liver function compared with controls.
Peptide
Exenatide (exendin-4)
Outcome
Not applicableLiver function
Study
ratn: not reported in source
Streptozotocin-induced diabetes
Comparator
Untreated controls
Outcome group
Liver fat and liver function · Liver
Studied dose
1 μg/kg body weight · 10 weeksAs given in this study (rat).
Source sentences
Summary
Similarly, exenatide enhanced insulin release from the pancreatic fragments and improved liver and kidney functions and lipid profile in diabetic rats compared with controls.
2 context sentences(design, population, supporting numbers)
Summary · context
This study examines the mechanism of the protective effects of exenatide in experimental diabetes, employing four groups of ten rats each, in which two groups were streptozotocin-induced diabetic and two were control groups.
Summary · context
One control and one diabetic group were treated with exenatide (1 μg/kg body weight (BW)) for 10 weeks.
Report a problemFND-2435330704
10AnimalAnimal study (in vivo)Efficacy outcome
In diabetic rats, exenatide improved kidney function compared with controls.
In plain wordsIn rats with diabetes, exenatide improved kidney function compared with controls.
Peptide
Exenatide (exendin-4)
Outcome
Not applicableKidney function
Study
ratn: not reported in source
Streptozotocin-induced diabetes
Comparator
Untreated controls
Outcome group
Kidney function · Kidney and urinary
Studied dose
1 μg/kg body weight · 10 weeksAs given in this study (rat).
Source sentences
Summary
Similarly, exenatide enhanced insulin release from the pancreatic fragments and improved liver and kidney functions and lipid profile in diabetic rats compared with controls.
2 context sentences(design, population, supporting numbers)
Summary · context
This study examines the mechanism of the protective effects of exenatide in experimental diabetes, employing four groups of ten rats each, in which two groups were streptozotocin-induced diabetic and two were control groups.
Summary · context
One control and one diabetic group were treated with exenatide (1 μg/kg body weight (BW)) for 10 weeks.
Report a problemFND-2435330705
11AnimalAnimal study (in vivo)Efficacy outcome
In diabetic rats, exenatide improved lipid profile compared with controls.
In plain wordsIn rats with diabetes, exenatide improved the blood fat profile compared with controls.
Peptide
Exenatide (exendin-4)
Outcome
Not applicableLipid profile
Study
ratn: not reported in source
Streptozotocin-induced diabetes
Comparator
Untreated controls
Outcome group
Lipids · Metabolic and weight
Studied dose
1 μg/kg body weight · 10 weeksAs given in this study (rat).
Source sentences
Summary
Similarly, exenatide enhanced insulin release from the pancreatic fragments and improved liver and kidney functions and lipid profile in diabetic rats compared with controls.
2 context sentences(design, population, supporting numbers)
Summary · context
This study examines the mechanism of the protective effects of exenatide in experimental diabetes, employing four groups of ten rats each, in which two groups were streptozotocin-induced diabetic and two were control groups.
Summary · context
One control and one diabetic group were treated with exenatide (1 μg/kg body weight (BW)) for 10 weeks.
Report a problemFND-2435330706
12AnimalAnimal study (in vivo)Mechanism
In rats, exenatide increased serum insulin compared with untreated controls.
In plain wordsIn rats, exenatide increased blood insulin compared with untreated controls.
Peptide
Exenatide (exendin-4)
Outcome
IncreaseSerum insulin
Study
ratn: not reported in source
Streptozotocin-induced diabetes
Comparator
Untreated controls
Outcome group
Glycemic control · Endocrine and hormones
Studied dose
1 μg/kg body weight · 10 weeksAs given in this study (rat).
Source sentences
Summary
Exenatide not only induced significant increases in serum insulin level but also elevated the number of insulin-, GLP1- and exenatide-positive cells compared with untreated controls.
2 context sentences(design, population, supporting numbers)
Summary · context
This study examines the mechanism of the protective effects of exenatide in experimental diabetes, employing four groups of ten rats each, in which two groups were streptozotocin-induced diabetic and two were control groups.
Summary · context
One control and one diabetic group were treated with exenatide (1 μg/kg body weight (BW)) for 10 weeks.
Report a problemFND-2435330707
13AnimalAnimal study (in vivo)Mechanism
In rats, exenatide increased insulin-positive cells compared with untreated controls.
In plain wordsIn rats, exenatide increased insulin-positive cells compared with untreated controls.
Peptide
Exenatide (exendin-4)
Outcome
IncreaseInsulin-positive cells
Study
ratn: not reported in source
Streptozotocin-induced diabetes
Comparator
Untreated controls
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
1 μg/kg body weight · 10 weeksAs given in this study (rat).
Source sentences
Summary
Exenatide not only induced significant increases in serum insulin level but also elevated the number of insulin-, GLP1- and exenatide-positive cells compared with untreated controls.
2 context sentences(design, population, supporting numbers)
Summary · context
This study examines the mechanism of the protective effects of exenatide in experimental diabetes, employing four groups of ten rats each, in which two groups were streptozotocin-induced diabetic and two were control groups.
Summary · context
One control and one diabetic group were treated with exenatide (1 μg/kg body weight (BW)) for 10 weeks.
Report a problemFND-2435330708
14AnimalAnimal study (in vivo)Mechanism
In rats, exenatide increased GLP1-positive cells compared with untreated controls.
In plain wordsIn rats, exenatide increased GLP1-positive cells compared with untreated controls.
Peptide
Exenatide (exendin-4)
Outcome
IncreaseGLP1-positive cells
Study
ratn: not reported in source
Streptozotocin-induced diabetes
Comparator
Untreated controls
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
1 μg/kg body weight · 10 weeksAs given in this study (rat).
Source sentences
Summary
Exenatide not only induced significant increases in serum insulin level but also elevated the number of insulin-, GLP1- and exenatide-positive cells compared with untreated controls.
2 context sentences(design, population, supporting numbers)
Summary · context
This study examines the mechanism of the protective effects of exenatide in experimental diabetes, employing four groups of ten rats each, in which two groups were streptozotocin-induced diabetic and two were control groups.
Summary · context
One control and one diabetic group were treated with exenatide (1 μg/kg body weight (BW)) for 10 weeks.
Report a problemFND-2435330709
15AnimalAnimal study (in vivo)Mechanism
In rats, exenatide increased exenatide-positive cells compared with untreated controls.
In plain wordsIn rats, exenatide increased exenatide-positive cells compared with untreated controls.
Peptide
Exenatide (exendin-4)
Outcome
IncreaseExenatide-positive cells
Study
ratn: not reported in source
Streptozotocin-induced diabetes
Comparator
Untreated controls
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
1 μg/kg body weight · 10 weeksAs given in this study (rat).
Source sentences
Summary
Exenatide not only induced significant increases in serum insulin level but also elevated the number of insulin-, GLP1- and exenatide-positive cells compared with untreated controls.
2 context sentences(design, population, supporting numbers)
Summary · context
This study examines the mechanism of the protective effects of exenatide in experimental diabetes, employing four groups of ten rats each, in which two groups were streptozotocin-induced diabetic and two were control groups.
Summary · context
One control and one diabetic group were treated with exenatide (1 μg/kg body weight (BW)) for 10 weeks.
Report a problemFND-2435330710
16AnimalAnimal study (in vivo)Mechanism
In diabetic rat pancreas, exenatide increased catalase-positive cells compared with controls.
In plain wordsIn rats with diabetes, exenatide increased pancreatic catalase-positive cells compared with controls.
Peptide
Exenatide (exendin-4)
Outcome
IncreaseCatalase-positive cells
Study
ratn: not reported in source
Streptozotocin-induced diabetes
Comparator
Untreated controls
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
1 μg/kg body weight · 10 weeksAs given in this study (rat).
Source sentences
Summary
Exenatide also elevated the number of catalase- and glutathione reductase-positive cells in diabetic rat pancreas compared with controls.
2 context sentences(design, population, supporting numbers)
Summary · context
This study examines the mechanism of the protective effects of exenatide in experimental diabetes, employing four groups of ten rats each, in which two groups were streptozotocin-induced diabetic and two were control groups.
Summary · context
One control and one diabetic group were treated with exenatide (1 μg/kg body weight (BW)) for 10 weeks.
Report a problemFND-2435330711
17AnimalAnimal study (in vivo)Mechanism
In diabetic rat pancreas, exenatide increased glutathione reductase-positive cells compared with controls.
In plain wordsIn rats with diabetes, exenatide increased pancreatic glutathione reductase-positive cells compared with controls.
Peptide
Exenatide (exendin-4)
Outcome
IncreaseGlutathione reductase-positive cells
Study
ratn: not reported in source
Streptozotocin-induced diabetes
Comparator
Untreated controls
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
1 μg/kg body weight · 10 weeksAs given in this study (rat).
Source sentences
Summary
Exenatide also elevated the number of catalase- and glutathione reductase-positive cells in diabetic rat pancreas compared with controls.
2 context sentences(design, population, supporting numbers)
Summary · context
This study examines the mechanism of the protective effects of exenatide in experimental diabetes, employing four groups of ten rats each, in which two groups were streptozotocin-induced diabetic and two were control groups.
Summary · context
One control and one diabetic group were treated with exenatide (1 μg/kg body weight (BW)) for 10 weeks.
Report a problemFND-2435330712

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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Mechanism of the beneficial and protective effects of exenatide in diabetic rats.

Summary

Results from this study17

Version history

Subjects

Publication types

MeSH terms

Keywords