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Study · Non-randomized trial · n = 16 · 2014

5 results

Differing effects of liraglutide on gastric emptying in Japanese patients with type 2 diabetes.

Nagai Y, Hashimoto E, Oikawa R, Asai S, Terashima Y, Nakamura Y, Sasaki Y, Tsukiyama H, Fukuda H, Ohshige T, Kato H, Ohta A, Tanaka Y

Diabetes, obesity & metabolism29 Dec 2013Cited by 15 (Europe PMC)

PMID24320758 (opens in a new tab)DOI10.1111/dom.12247 (opens in a new tab)PepBankPUB-24320758
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. 5 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In 16 Japanese patients with type 2 diabetes, liraglutide delayed gastric emptying in seven patients (delayers) and did not delay it in nine (non-delayers).

    In plain wordsIn Japanese patients with type 2 diabetes, liraglutide slowed stomach emptying in seven of 16 patients but not in the other nine.

    Peptide
    Liraglutide
    Outcome
    MixedGastric emptying response pattern
    Study

    n = 16

    Comparator
    Baseline before liraglutide
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We found two patterns of response, with gastric emptying being delayed by liraglutide in seven patients (delayers) and not delayed in nine patients (non-delayers).
    1 context sentence
    Summary · context
    In 16 patients, the [(13) C]-acetate breath test was performed to compare gastric emptying before and after liraglutide treatment.
  2. 02HumanNon-randomized trialEfficacy outcome

    In Japanese patients with type 2 diabetes on liraglutide, delayers showed a greater early decrease of plasma glucose AUC from 0 to 60 min than non-delayers.

    In plain wordsIn Japanese patients with type 2 diabetes on liraglutide, those with slowed stomach emptying had a bigger early blood glucose fall than the others.

    Peptide
    Liraglutide
    Outcome
    DecreaseEarly plasma glucose AUC (0-60 min), delayers versus non-delayers
    Study

    n = 16

    Comparator
    Non-delayers
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The delayers showed a greater early decrease of AUC-PG from 0 to 60 min
    1 context sentence
    Summary · context
    In 16 patients, the [(13) C]-acetate breath test was performed to compare gastric emptying before and after liraglutide treatment.
  3. 03HumanNon-randomized trialEfficacy outcome

    In Japanese patients with type 2 diabetes on liraglutide, plasma insulin did not increase in delayers compared with non-delayers.

    In plain wordsIn Japanese patients with type 2 diabetes on liraglutide, insulin levels were not higher in those with slowed stomach emptying than in the others.

    Peptide
    Liraglutide
    Outcome
    No significant changePlasma insulin level, delayers versus non-delayers
    Study

    n = 16

    Comparator
    Non-delayers
    Outcome group
    Glycemic control · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    despite no increase of the plasma insulin level compared with non-delayers.
    1 context sentence
    Summary · context
    In 16 patients, the [(13) C]-acetate breath test was performed to compare gastric emptying before and after liraglutide treatment.
  4. 04HumanNon-randomized trialEfficacy outcome

    In nine Japanese patients with type 2 diabetes whose gastric emptying was not delayed, the maximum gastric emptying time did not change significantly versus baseline.

    In plain wordsIn nine Japanese patients with type 2 diabetes who did not respond, liraglutide did not clearly change the longest stomach emptying time.

    Peptide
    Liraglutide
    Outcome
    No significant changeMaximum gastric emptying time, non-delayers
    Study

    n = 9

    Comparator
    Baseline before liraglutide
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    Dose not stated

    Measurements

    Increase in maximum gastric emptying time
    2 min
    non-delayers

    Source sentences

    Summary
    while it was only 2 ± 3 min (p = 0.60 vs. baseline) in the non-delayers.
    1 context sentence
    Summary · context
    In 16 patients, the [(13) C]-acetate breath test was performed to compare gastric emptying before and after liraglutide treatment.
  5. 05HumanNon-randomized trialEfficacy outcome

    In seven Japanese patients with type 2 diabetes whose gastric emptying was delayed, the maximum gastric emptying time rose by 31 min versus baseline.

    In plain wordsIn seven Japanese patients with type 2 diabetes who responded, liraglutide lengthened the longest stomach emptying time by 31 minutes versus baseline.

    Peptide
    Liraglutide
    Outcome
    IncreaseMaximum gastric emptying time, delayers
    Study

    n = 7

    Comparator
    Baseline before liraglutide
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    Dose not stated

    Measurements

    Increase in maximum gastric emptying time
    31 min
    delayers

    Source sentences

    Summary
    The mean increase of the maximum gastric emptying time was 31 ± 4 min (p < 0.01 vs. baseline) in the delayers
    1 context sentence
    Summary · context
    In 16 patients, the [(13) C]-acetate breath test was performed to compare gastric emptying before and after liraglutide treatment.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:10 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:05 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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