[Protective effect of thymosin β4 against oxidative damage in cultured rabbit corneal epithelial cells].

Li X, Jiang ZX, Hao P, Tang X

[Zhonghua yan ke za zhi] Chinese journal of ophthalmology1 Aug 2013Cited by 1 (Europe PMC)

PMID24246811PepBankPUB-24246811

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Efficacy outcome
In rabbit corneal epithelial cells exposed to H2O2, Tβ4 significantly improved cell viability versus H2O2 alone.
In plain wordsIn cells, Tβ4 improved the survival of rabbit corneal cells damaged by hydrogen peroxide, compared with hydrogen peroxide alone.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseCell viability after H2O2 injury
Study
rabbitn: not reported in source
primary rabbit corneal epithelial cells
Comparator
H2O2 group
Outcome group
Oxidative stress · Eye
Studied dose
Dose not stated
Measurements
Cell viability
83.42%
Tβ4 + H2O2
Cell viability
67.2%
H2O2
Source sentences
Summary
the cell viability was significantly improved in Tβ4+ H2O2 group than that in H2O2 group (83.42% ± 7.23% vs. 67.20% ± 5.87%, P = 0.023) .
1 context sentence(design, population, supporting numbers)
Summary · context
The cultures were divided into 4 groups: control group, Tβ4 group, hydrogen peroxide (H2O2) group, and H2O2+Tβ4 group.
Report a problemFND-2424681101
02LabIn vitro (cells)Efficacy outcome
In rabbit corneal epithelial cells, cell migration was significantly increased in the Tβ4 group compared with controls.
In plain wordsIn cells, Tβ4 made rabbit corneal cells migrate more than untreated control cells.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseCell migration with Tβ4 alone
Study
rabbitn: not reported in source
primary rabbit corneal epithelial cells
Comparator
Control
Outcome group
Wound healing · Eye
Studied dose
Dose not stated
Measurements
Cell migration
117.6%
Tβ4 group
Cell migration
100%
control
Source sentences
Summary
Cell migration was significantly increased in Tβ4 group compared with the controls (117.6% ± 2.22% vs. 100.00% ± 4.06%, P = 0.005)
1 context sentence(design, population, supporting numbers)
Summary · context
The cultures were divided into 4 groups: control group, Tβ4 group, hydrogen peroxide (H2O2) group, and H2O2+Tβ4 group.
Report a problemFND-2424681102
03LabIn vitro (cells)Efficacy outcome
In rabbit corneal epithelial cells exposed to H2O2, cell migration was significantly higher with Tβ4 than with H2O2 alone.
In plain wordsIn cells, Tβ4 increased migration of rabbit corneal cells damaged by hydrogen peroxide, compared with hydrogen peroxide alone.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseCell migration after H2O2 injury
Study
rabbitn: not reported in source
primary rabbit corneal epithelial cells
Comparator
H2O2 group
Outcome group
Wound healing · Eye
Studied dose
Dose not stated
Measurements
Cell migration
96.57%
H2O2 + Tβ4
Cell migration
64.38%
H2O2
Source sentences
Summary
Compared with H2O2 group, cell migration was significant increase in H2O2 + Tβ4 group (96.57% ± 8.22% vs. 64.38% ± 11.08%, P = 0.000) .
1 context sentence(design, population, supporting numbers)
Summary · context
The cultures were divided into 4 groups: control group, Tβ4 group, hydrogen peroxide (H2O2) group, and H2O2+Tβ4 group.
Report a problemFND-2424681103
04LabIn vitro (cells)Efficacy outcome
In rabbit corneal epithelial cells exposed to H2O2, Tβ4 significantly decreased intracellular ROS versus H2O2 alone.
In plain wordsIn cells, Tβ4 lowered reactive oxygen levels in rabbit corneal cells damaged by hydrogen peroxide, compared with hydrogen peroxide alone.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseIntracellular ROS level after H2O2 injury
Study
rabbitn: not reported in source
primary rabbit corneal epithelial cells
Comparator
H2O2 group
Outcome group
Oxidative stress · Eye
Studied dose
Dose not stated
Measurements
Intracellular ROS
163.26%
H2O2 + Tβ4
Intracellular ROS
234.42%
H2O2
Source sentences
Summary
Intracellular ROS level of H2O2+Tβ4 group was significantly decreased as compared with the H2O2 group (163.26% ± 10.53% vs. 234.42% ± 22.15%, P = 0.000).
1 context sentence(design, population, supporting numbers)
Summary · context
The cultures were divided into 4 groups: control group, Tβ4 group, hydrogen peroxide (H2O2) group, and H2O2+Tβ4 group.
Report a problemFND-2424681104
05LabIn vitro (cells)Efficacy outcome
In rabbit corneal epithelial cells, Tβ4 treatment markedly inhibited H2O2-induced apoptosis on TUNEL staining.
In plain wordsIn cells, Tβ4 reduced cell death caused by hydrogen peroxide in rabbit corneal cells.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseH2O2-induced apoptosis
Study
rabbitn: not reported in source
primary rabbit corneal epithelial cells
Comparator
H2O2 group
Outcome group
Oxidative stress · Eye
Studied dose
Dose not stated
Source sentences
Summary
TUNEL staining indicated that Tβ4 treatment markedly inhibited H2O2-induced apoptosis in cultured corneal epithelial cells.
1 context sentence(design, population, supporting numbers)
Summary · context
The cultures were divided into 4 groups: control group, Tβ4 group, hydrogen peroxide (H2O2) group, and H2O2+Tβ4 group.
Report a problemFND-2424681105

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 01:52 UTC
Study results updated
Version 1
12 Oct 2026, 18:17 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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