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Study · In vitro (cells) · 2013

2 results

Islet amyloid polypeptide toxicity and membrane interactions.

Cao P, Abedini A, Wang H, Tu LH, Zhang X, Schmidt AM, Raleigh DP

Proceedings of the National Academy of Sciences of the United States of America11 Nov 2013Cited by 120 (Europe PMC)

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Safety outcome

    In cytotoxicity assays, pramlintide was not cytotoxic.

    In plain wordsIn cells, pramlintide did not show toxicity in the reported assays.

    Outcome
    No significant changeCytotoxicity
    Study

    n: not reported in source

    IAPP biophysical and cytotoxicity assays
    Outcome group
    Adverse events · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    and pramlintide, a US Food and Drug Administration-approved IAPP variant all induce membrane leakage, but are not cytotoxic,
  2. 02LabIn vitro (cell-free)Activity measurement

    In model membrane assays, pramlintide induced membrane leakage.

    In plain wordsIn lab tests, pramlintide caused model membranes to leak.

    Outcome
    IncreaseMembrane leakage
    Study

    n: not reported in source

    IAPP biophysical and cytotoxicity assays
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    and pramlintide, a US Food and Drug Administration-approved IAPP variant all induce membrane leakage, but are not cytotoxic,

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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