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Study · Animal study (in vivo) · mouse · 2014

6 results

The neuroprotective effect of carnosine (β-alanyl-L-histidine) on retinal ganglion cell following ischemia-reperfusion injury.

Ji YS, Park JW, Heo H, Park JS, Park SW

Current eye research8 Nov 2013Cited by 16 (Europe PMC)

PMID24206188 (opens in a new tab)DOI10.3109/02713683.2013.855235 (opens in a new tab)PepBankPUB-24206188
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In mice with retinal ischemia, carnosine decreased elevated retinal HIF-1α expression compared with saline.

    In plain wordsIn mice with retinal ischemia, carnosine decreased elevated retinal HIF-1α expression compared with saline.

    Peptide
    L-carnosine
    Outcome
    DecreaseRetinal HIF-1α expression
    Study

    mousen: not reported in source

    Retinal ischemia-reperfusion injury in C57BL/6 J mice
    Comparator
    Saline-treated ischemic retina
    Outcome group
    Neuroprotection · Eye
    Studied dose
    1000 mg/kgAs given in this study (mouse).

    Source sentences

    Summary
    Carnosine treatment effectively decreased the elevated expression of HIF-1α, GFAP, and Drp-1 in ischemic mouse retina.
    1 context sentence
    Summary · context
    Retinal ischemia was induced by constant elevation of intraocular pressure (100-110 mmHg) for 60 min in C57BL/6 J mice pretreated with carnosine (1000 mg/kg) or saline.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In mice with retinal ischemia, carnosine decreased elevated retinal GFAP expression compared with saline.

    In plain wordsIn mice with retinal ischemia, carnosine decreased elevated retinal GFAP expression compared with saline.

    Peptide
    L-carnosine
    Outcome
    DecreaseRetinal GFAP expression
    Study

    mousen: not reported in source

    Retinal ischemia-reperfusion injury in C57BL/6 J mice
    Comparator
    Saline-treated ischemic retina
    Outcome group
    Neuroprotection · Eye
    Studied dose
    1000 mg/kgAs given in this study (mouse).

    Source sentences

    Summary
    Carnosine treatment effectively decreased the elevated expression of HIF-1α, GFAP, and Drp-1 in ischemic mouse retina.
    1 context sentence
    Summary · context
    Retinal ischemia was induced by constant elevation of intraocular pressure (100-110 mmHg) for 60 min in C57BL/6 J mice pretreated with carnosine (1000 mg/kg) or saline.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In mice with retinal ischemia, carnosine decreased elevated retinal Drp-1 expression compared with saline.

    In plain wordsIn mice with retinal ischemia, carnosine decreased elevated retinal Drp-1 expression compared with saline.

    Peptide
    L-carnosine
    Outcome
    DecreaseRetinal Drp-1 expression
    Study

    mousen: not reported in source

    Retinal ischemia-reperfusion injury in C57BL/6 J mice
    Comparator
    Saline-treated ischemic retina
    Outcome group
    Neuroprotection · Eye
    Studied dose
    1000 mg/kgAs given in this study (mouse).

    Source sentences

    Summary
    Carnosine treatment effectively decreased the elevated expression of HIF-1α, GFAP, and Drp-1 in ischemic mouse retina.
    1 context sentence
    Summary · context
    Retinal ischemia was induced by constant elevation of intraocular pressure (100-110 mmHg) for 60 min in C57BL/6 J mice pretreated with carnosine (1000 mg/kg) or saline.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In mice with retinal ischemia, carnosine decreased Bax expression compared with saline.

    In plain wordsIn mice with retinal ischemia, carnosine decreased Bax expression compared with saline.

    Peptide
    L-carnosine
    Outcome
    DecreaseRetinal Bax expression
    Study

    mousen: not reported in source

    Retinal ischemia-reperfusion injury in C57BL/6 J mice
    Comparator
    Saline-treated ischemic retina
    Outcome group
    Neuroprotection · Eye
    Studied dose
    1000 mg/kgAs given in this study (mouse).

    Source sentences

    Summary
    In ischemic retina treated with carnosine, Bax expression was decreased, whereas Bcl-2 expression was increased compared with ischemic retina treated with saline.
    1 context sentence
    Summary · context
    Retinal ischemia was induced by constant elevation of intraocular pressure (100-110 mmHg) for 60 min in C57BL/6 J mice pretreated with carnosine (1000 mg/kg) or saline.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In mice with retinal ischemia, carnosine increased Bcl-2 expression compared with saline.

    In plain wordsIn mice with retinal ischemia, carnosine increased Bcl-2 expression compared with saline.

    Peptide
    L-carnosine
    Outcome
    IncreaseRetinal Bcl-2 expression
    Study

    mousen: not reported in source

    Retinal ischemia-reperfusion injury in C57BL/6 J mice
    Comparator
    Saline-treated ischemic retina
    Outcome group
    Neuroprotection · Eye
    Studied dose
    1000 mg/kgAs given in this study (mouse).

    Source sentences

    Summary
    In ischemic retina treated with carnosine, Bax expression was decreased, whereas Bcl-2 expression was increased compared with ischemic retina treated with saline.
    1 context sentence
    Summary · context
    Retinal ischemia was induced by constant elevation of intraocular pressure (100-110 mmHg) for 60 min in C57BL/6 J mice pretreated with carnosine (1000 mg/kg) or saline.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In mice with retinal ischemia, carnosine protected against retinal ganglion cell loss compared with saline.

    In plain wordsIn mice with retinal ischemia, carnosine reduced retinal ganglion cell loss compared with saline.

    Peptide
    L-carnosine
    Outcome
    DecreaseRetinal ganglion cell loss
    Study

    mousen: not reported in source

    Retinal ischemia-reperfusion injury in C57BL/6 J mice
    Comparator
    Saline-treated ischemic retina
    Outcome group
    Neuroprotection · Eye
    Studied dose
    1000 mg/kgAs given in this study (mouse).

    Source sentences

    Summary
    Carnosine treatment also protected against RGC loss in ischemia mouse retina.
    1 context sentence
    Summary · context
    Retinal ischemia was induced by constant elevation of intraocular pressure (100-110 mmHg) for 60 min in C57BL/6 J mice pretreated with carnosine (1000 mg/kg) or saline.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

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