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Study · Measured the body's own peptide · 2014

3 results

Nicotinamide pre-treatment ameliorates NAD(H) hyperoxidation and improves neuronal function after severe hypoxia.

Shetty PK, Galeffi F, Turner DA

Neurobiology of disease31 Oct 2013Cited by 30 (Europe PMC)

PMID24184921 (opens in a new tab)PMCIDPMC4143422 (opens in a new tab)DOI10.1016/j.nbd.2013.10.025 (opens in a new tab)PepBankPUB-24184921
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01LabEndogenous levelEx vivo tissueMechanism

    In hippocampal slices, severe prolonged hypoxia increased the soluble NAD(+)/NADH ratio after reoxygenation.

    In plain wordsIn lab tests, severe prolonged hypoxia increased the ratio of natural NAD to NADH after reoxygenation.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    IncreaseSoluble NAD/NADH ratio
    Study

    n: not reported in source

    Hippocampal slices
    Outcome group
    Mitochondrial function · Nervous system and cognition

    Source sentences

    Summary
    After severe, prolonged hypoxia (maintained for 3min after spreading depression) there was hyperoxidation of NADH following reoxygenation, an increased soluble NAD(+)/NADH ratio, loss of neuronal field excitatory post-synaptic potential (fEPSP) and decreased ATP content.
    1 context sentence
    Summary · context
    We test whether the addition of nicotinamide (to enhance NAD(+) levels) or PARP-1 inhibition (to prevent consumption of NAD(+)) can be effective in improving either loss of neuronal function or hyperoxidation following severe hypoxic injury in hippocampal slices.

    This result measures the body's own NAD+ (nicotinamide adenine dinucleotide). Nobody was given the peptide. It is not evidence about taking it.

Studies that did not test the peptide alone2

In this study, NAD+ (nicotinamide adenine dinucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking NAD+ (nicotinamide adenine dinucleotide).

  1. 02LabNot a test of NAD+ (nicotinamide adenine dinucleotide) aloneEx vivo tissueMechanism

    In hippocampal slices, nicotinamide pretreatment significantly increased total NAD(H) content.

    In plain wordsIn lab tests, nicotinamide pretreatment increased natural NAD(H) content.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    IncreaseTotal NAD(H) content
    Study

    n: not reported in source

    Hippocampal slices
    Outcome group
    Mitochondrial function · Nervous system and cognition

    Source sentences

    Summary
    Nicotinamide incubation (5mM) 2h prior to hypoxia significantly increased total NAD(H) content, improved neuronal recovery, enhanced ATP content, and prevented NADH hyperoxidation.
    1 context sentence
    Summary · context
    We test whether the addition of nicotinamide (to enhance NAD(+) levels) or PARP-1 inhibition (to prevent consumption of NAD(+)) can be effective in improving either loss of neuronal function or hyperoxidation following severe hypoxic injury in hippocampal slices.

    In this study, NAD+ (nicotinamide adenine dinucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NAD+ (nicotinamide adenine dinucleotide).

  2. 03LabNot a test of NAD+ (nicotinamide adenine dinucleotide) aloneEx vivo tissueMechanism

    In hippocampal slices, nicotinamide increased total soluble NAD(H) more significantly in cytosol than mitochondria.

    In plain wordsIn lab tests, nicotinamide increased natural soluble NAD(H) more significantly in cytosol than mitochondria.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    IncreaseCompartmental NAD(H) increase
    Study

    n: not reported in source

    Hippocampal slices
    Comparator
    Mitochondrial compartment
    Outcome group
    Mitochondrial function · Nervous system and cognition

    Source sentences

    Summary
    The nicotinamide-induced increase in total soluble NAD(H) was more significant in the cytosolic compartment than within mitochondria.
    1 context sentence
    Summary · context
    We test whether the addition of nicotinamide (to enhance NAD(+) levels) or PARP-1 inhibition (to prevent consumption of NAD(+)) can be effective in improving either loss of neuronal function or hyperoxidation following severe hypoxic injury in hippocampal slices.

    In this study, NAD+ (nicotinamide adenine dinucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NAD+ (nicotinamide adenine dinucleotide).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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