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Study · In vitro (cells) · 2014

4 results

Activity of pramlintide, rat and human amylin but not Aβ1-42 at human amylin receptors.

Gingell JJ, Burns ER, Hay DL

Endocrinology20 Dec 2013Cited by 53 (Europe PMC)

PMID24169554 (opens in a new tab)DOI10.1210/en.2013-1658 (opens in a new tab)PepBankPUB-24169554
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In kidney cell assays, pramlintide activated the calcitonin receptor.

    In plain wordsIn cells, pramlintide activated the calcitonin receptor.

    Peptide
    Pramlintide (Symlin)
    Outcome
    IncreaseCalcitonin receptor activation
    Study

    n: not reported in source

    Human embryonic kidney 293S and Cos 7 cells
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Pramlintide activated all receptors with a slight preference for AMY1.
    1 context sentence
    Summary · context
    We investigated the actions of Aβ1-42 and pramlintide, compared with human and rat amylin at the calcitonin receptor, AMY1, AMY2, and AMY3 receptors, measuring the cAMP response in human embryonic kidney 293S and Cos 7 cells.
  2. 02LabIn vitro (cells)Activity measurement

    In kidney cell assays, pramlintide activated AMY1, with a slight preference for this receptor subtype.

    In plain wordsIn cells, pramlintide activated AMY1 and showed a slight preference for this receptor subtype.

    Peptide
    Pramlintide (Symlin)
    Outcome
    IncreaseAMY1 receptor activation
    Study

    n: not reported in source

    Human embryonic kidney 293S and Cos 7 cells
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Pramlintide activated all receptors with a slight preference for AMY1.
    1 context sentence
    Summary · context
    We investigated the actions of Aβ1-42 and pramlintide, compared with human and rat amylin at the calcitonin receptor, AMY1, AMY2, and AMY3 receptors, measuring the cAMP response in human embryonic kidney 293S and Cos 7 cells.
  3. 03LabIn vitro (cells)Activity measurement

    In kidney cell assays, pramlintide activated AMY2.

    In plain wordsIn cells, pramlintide activated AMY2.

    Peptide
    Pramlintide (Symlin)
    Outcome
    IncreaseAMY2 receptor activation
    Study

    n: not reported in source

    Human embryonic kidney 293S and Cos 7 cells
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Pramlintide activated all receptors with a slight preference for AMY1.
    1 context sentence
    Summary · context
    We investigated the actions of Aβ1-42 and pramlintide, compared with human and rat amylin at the calcitonin receptor, AMY1, AMY2, and AMY3 receptors, measuring the cAMP response in human embryonic kidney 293S and Cos 7 cells.
  4. 04LabIn vitro (cells)Activity measurement

    In kidney cell assays, pramlintide activated AMY3.

    In plain wordsIn cells, pramlintide activated AMY3.

    Peptide
    Pramlintide (Symlin)
    Outcome
    IncreaseAMY3 receptor activation
    Study

    n: not reported in source

    Human embryonic kidney 293S and Cos 7 cells
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Pramlintide activated all receptors with a slight preference for AMY1.
    1 context sentence
    Summary · context
    We investigated the actions of Aβ1-42 and pramlintide, compared with human and rat amylin at the calcitonin receptor, AMY1, AMY2, and AMY3 receptors, measuring the cAMP response in human embryonic kidney 293S and Cos 7 cells.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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