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Study · Not a test of the peptide alone · 2013

1 result

Renal tubular Sirt1 attenuates diabetic albuminuria by epigenetically suppressing Claudin-1 overexpression in podocytes.

Hasegawa K, Wakino S, Simic P, Sakamaki Y, Minakuchi H, Fujimura K, Hosoya K, Komatsu M, Kaneko Y, Kanda T, Kubota E, Tokuyama H, Hayashi K, Guarente L, Itoh H

Nature medicine20 Oct 2013Cited by 406 (Europe PMC)

PMID24141423 (opens in a new tab)PMCIDPMC4041199 (opens in a new tab)DOI10.1038/nm.3363 (opens in a new tab)PepBankPUB-24141423
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone1

In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking NMN (nicotinamide mononucleotide).

  1. 01AnimalNot a test of NMN (nicotinamide mononucleotide) aloneAnimal study (in vivo)Mechanism

    In renal experiments, NMN tracing demonstrated retrograde interplay from proximal tubules to glomeruli.

    In plain wordsIn mice, experiments with NMN showed communication from kidney tubules to glomeruli.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    Not applicableRetrograde proximal tubule–glomerular interplay
    Study

    mousen: not reported in source

    Renal proximal tubule–glomerular interplay
    Outcome group
    Receptor activity and mechanism · Kidney and urinary

    Source sentences

    Summary
    We also demonstrated retrograde interplay from PTs to glomeruli using nicotinamide mononucleotide (NMN) from conditioned medium, measurement of the autofluorescence of photoactivatable NMN and injection of fluorescence-labeled NMN.

    In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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