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Study · In vitro (cells) · 2013

9 results

Glucagonlike peptide 2 analogue teduglutide: stimulation of proliferation but reduction of differentiation in human Caco-2 intestinal epithelial cells.

Chaturvedi LS, Basson MD

JAMA surgery1 Nov 2013Cited by 12 (Europe PMC)

PMID24068167 (opens in a new tab)PMCIDPMC4574866 (opens in a new tab)DOI10.1001/jamasurg.2013.3731 (opens in a new tab)PepBankPUB-24068167
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In Caco-2 cells, teduglutide increased cell numbers by a mean of 10% (SD 2%) over untreated controls at maximal 500 nM (P < .05).

    In plain wordsIn cells, teduglutide increased Caco-2 cell numbers by 10% compared with untreated controls.

    Peptide
    Teduglutide
    Outcome
    IncreaseCell numbers by MTS assay
    Study

    humann = 6

    Caco-2 intestinal epithelial cells
    Comparator
    Untreated controls
    Outcome group
    Receptor activity and mechanism · Gastrointestinal
    Studied dose
    500 nMAs given in this study (human).

    Source sentences

    Summary
    The MTS assay demonstrated that teduglutide increased cell numbers by a mean (SD) of 10% (2%) over untreated controls at a maximal 500 nM (n = 6, P < .05).
    2 context sentences
    Summary · context
    This was an in vitro study using Caco-2 cells, a human-derived intestinal epithelial cell line commonly used to model enterocytic biology.
    Summary · context
    Cells were exposed to teduglutide or vehicle control.
  2. 02LabIn vitro (cells)Mechanism

    In Caco-2 cells, bromodeoxyuridine-positive cells were 19.4% (SD 2.3%) with teduglutide versus 12.0% (SD 0.8%) in untreated controls (P < .05).

    In plain wordsIn cells, teduglutide increased bromodeoxyuridine-positive Caco-2 cells compared with untreated controls.

    Peptide
    Teduglutide
    Outcome
    IncreaseBromodeoxyuridine-positive cells
    Study

    humann = 6

    Caco-2 intestinal epithelial cells
    Comparator
    Untreated controls
    Outcome group
    Receptor activity and mechanism · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Teduglutide increased bromodeoxyuridine-positive cells vs untreated controls by a mean (SD) of 19.4% (2.3%) vs 12.0% (0.8%) (n = 6, P < .05) and increased the S-phase fraction by flow cytometric analysis.
    2 context sentences
    Summary · context
    This was an in vitro study using Caco-2 cells, a human-derived intestinal epithelial cell line commonly used to model enterocytic biology.
    Summary · context
    Cells were exposed to teduglutide or vehicle control.
  3. 03LabIn vitro (cells)Mechanism

    In Caco-2 cells, teduglutide reduced villin expression by a mean of 29% (SD 6%) versus untreated controls (P < .05).

    In plain wordsIn cells, teduglutide reduced Caco-2 villin expression by 29% compared with untreated controls.

    Peptide
    Teduglutide
    Outcome
    DecreaseVillin expression
    Study

    humann = 6

    Caco-2 intestinal epithelial cells
    Comparator
    Untreated controls
    Outcome group
    Receptor activity and mechanism · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Teduglutide reduced the mean (SD) expression of villin by 29% (6%), Cdx2 by 31% (10%), DPP-4 by 15% (6%), GLUT2 by 40% (11%), SLFN12 by 61% (14%), and sucrase-isomaltase by 28% (8%) (n = 6, P < .05 for all).
    2 context sentences
    Summary · context
    This was an in vitro study using Caco-2 cells, a human-derived intestinal epithelial cell line commonly used to model enterocytic biology.
    Summary · context
    Cells were exposed to teduglutide or vehicle control.
  4. 04LabIn vitro (cells)Mechanism

    In Caco-2 cells, teduglutide reduced Cdx2 expression by a mean of 31% (SD 10%) versus untreated controls (P < .05).

    In plain wordsIn cells, teduglutide reduced Caco-2 Cdx2 expression by 31% compared with untreated controls.

    Peptide
    Teduglutide
    Outcome
    DecreaseCdx2 expression
    Study

    humann = 6

    Caco-2 intestinal epithelial cells
    Comparator
    Untreated controls
    Outcome group
    Receptor activity and mechanism · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Teduglutide reduced the mean (SD) expression of villin by 29% (6%), Cdx2 by 31% (10%), DPP-4 by 15% (6%), GLUT2 by 40% (11%), SLFN12 by 61% (14%), and sucrase-isomaltase by 28% (8%) (n = 6, P < .05 for all).
    2 context sentences
    Summary · context
    This was an in vitro study using Caco-2 cells, a human-derived intestinal epithelial cell line commonly used to model enterocytic biology.
    Summary · context
    Cells were exposed to teduglutide or vehicle control.
  5. 05LabIn vitro (cells)Mechanism

    In Caco-2 cells, teduglutide reduced DPP-4 expression by a mean of 15% (SD 6%) versus untreated controls (P < .05).

    In plain wordsIn cells, teduglutide reduced Caco-2 DPP-4 expression by 15% compared with untreated controls.

    Peptide
    Teduglutide
    Outcome
    DecreaseDPP-4 expression
    Study

    humann = 6

    Caco-2 intestinal epithelial cells
    Comparator
    Untreated controls
    Outcome group
    Receptor activity and mechanism · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Teduglutide reduced the mean (SD) expression of villin by 29% (6%), Cdx2 by 31% (10%), DPP-4 by 15% (6%), GLUT2 by 40% (11%), SLFN12 by 61% (14%), and sucrase-isomaltase by 28% (8%) (n = 6, P < .05 for all).
    2 context sentences
    Summary · context
    This was an in vitro study using Caco-2 cells, a human-derived intestinal epithelial cell line commonly used to model enterocytic biology.
    Summary · context
    Cells were exposed to teduglutide or vehicle control.
  6. 06LabIn vitro (cells)Mechanism

    In Caco-2 cells, teduglutide reduced GLUT2 expression by a mean of 40% (SD 11%) versus untreated controls (P < .05).

    In plain wordsIn cells, teduglutide reduced Caco-2 GLUT2 expression by 40% compared with untreated controls.

    Peptide
    Teduglutide
    Outcome
    DecreaseGLUT2 expression
    Study

    humann = 6

    Caco-2 intestinal epithelial cells
    Comparator
    Untreated controls
    Outcome group
    Receptor activity and mechanism · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Teduglutide reduced the mean (SD) expression of villin by 29% (6%), Cdx2 by 31% (10%), DPP-4 by 15% (6%), GLUT2 by 40% (11%), SLFN12 by 61% (14%), and sucrase-isomaltase by 28% (8%) (n = 6, P < .05 for all).
    2 context sentences
    Summary · context
    This was an in vitro study using Caco-2 cells, a human-derived intestinal epithelial cell line commonly used to model enterocytic biology.
    Summary · context
    Cells were exposed to teduglutide or vehicle control.
  7. 07LabIn vitro (cells)Mechanism

    In Caco-2 cells, teduglutide reduced SLFN12 expression by a mean of 61% (SD 14%) versus untreated controls (P < .05).

    In plain wordsIn cells, teduglutide reduced Caco-2 SLFN12 expression by 61% compared with untreated controls.

    Peptide
    Teduglutide
    Outcome
    DecreaseSLFN12 expression
    Study

    humann = 6

    Caco-2 intestinal epithelial cells
    Comparator
    Untreated controls
    Outcome group
    Receptor activity and mechanism · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Teduglutide reduced the mean (SD) expression of villin by 29% (6%), Cdx2 by 31% (10%), DPP-4 by 15% (6%), GLUT2 by 40% (11%), SLFN12 by 61% (14%), and sucrase-isomaltase by 28% (8%) (n = 6, P < .05 for all).
    2 context sentences
    Summary · context
    This was an in vitro study using Caco-2 cells, a human-derived intestinal epithelial cell line commonly used to model enterocytic biology.
    Summary · context
    Cells were exposed to teduglutide or vehicle control.
  8. 08LabIn vitro (cells)Mechanism

    In Caco-2 cells, teduglutide reduced sucrase-isomaltase expression by a mean of 28% (SD 8%) versus untreated controls (P < .05).

    In plain wordsIn cells, teduglutide reduced Caco-2 sucrase-isomaltase expression by 28% compared with untreated controls.

    Peptide
    Teduglutide
    Outcome
    DecreaseSucrase-isomaltase expression
    Study

    humann = 6

    Caco-2 intestinal epithelial cells
    Comparator
    Untreated controls
    Outcome group
    Receptor activity and mechanism · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Teduglutide reduced the mean (SD) expression of villin by 29% (6%), Cdx2 by 31% (10%), DPP-4 by 15% (6%), GLUT2 by 40% (11%), SLFN12 by 61% (14%), and sucrase-isomaltase by 28% (8%) (n = 6, P < .05 for all).
    2 context sentences
    Summary · context
    This was an in vitro study using Caco-2 cells, a human-derived intestinal epithelial cell line commonly used to model enterocytic biology.
    Summary · context
    Cells were exposed to teduglutide or vehicle control.
  9. 09LabIn vitro (cells)Mechanism

    In Caco-2 cells, teduglutide increased the S-phase fraction versus untreated controls by flow cytometric analysis.

    In plain wordsIn cells, teduglutide increased the Caco-2 S-phase fraction compared with untreated controls.

    Peptide
    Teduglutide
    Outcome
    IncreaseS-phase fraction
    Study

    humann: not reported in source

    Caco-2 intestinal epithelial cells
    Comparator
    Untreated controls
    Outcome group
    Receptor activity and mechanism · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Teduglutide increased bromodeoxyuridine-positive cells vs untreated controls by a mean (SD) of 19.4% (2.3%) vs 12.0% (0.8%) (n = 6, P < .05) and increased the S-phase fraction by flow cytometric analysis.
    2 context sentences
    Summary · context
    This was an in vitro study using Caco-2 cells, a human-derived intestinal epithelial cell line commonly used to model enterocytic biology.
    Summary · context
    Cells were exposed to teduglutide or vehicle control.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:37 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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