The neuroprotection of Rattin against amyloid β peptide in spatial memory and synaptic plasticity of rats.

Wang ZJ, Han WN, Yang GZ, Yuan L, Liu XJ, Li QS, Qi JS

Hippocampus30 Sept 2013Cited by 13 (Europe PMC)

PMID23996574DOI10.1002/hipo.22202PepBankPUB-23996574

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Humanin.

01AnimalNot a test of Humanin aloneAnimal study (in vivo)Efficacy outcome
In rats, intra-hippocampal Rattin, a rat derivative of humanin, prevented the spatial memory deficit induced by Aβ31-35.
In plain wordsIn rats, Rattin, a rat form related to humanin, prevented memory problems caused by Aβ31-35.
Peptide
Humanin
Outcome
DecreaseAβ31-35-induced spatial memory deficit
Study
ratn: not reported in source
Aβ31-35 injection model
Comparator
Aβ31-35 without Rattin
Outcome group
Cognition and memory · Nervous system and cognition
Source sentences
Summary
We showed that intra-hippocampal injection of Rattin effectively prevented the Aβ31-35-induced spatial memory deficits
2 context sentences(design, population, supporting numbers)
Summary · context
Rattin, a specific derivative of humanin in rats, shares the ability with HN to protect neurons against amyloid β (Aβ) peptide-induced cellular toxicity.
Summary · context
In the present study, we observed the effects of Rattin and Aβ31-35 on the spatial reference memory and in vivo hippocampal Long-term potentiation of rats by using Morris water maze test and hippocampal field potential recording.
In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.
Report a problemFND-2399657401
02AnimalNot a test of Humanin aloneAnimal study (in vivo)Efficacy outcome
In rats, intra-hippocampal Rattin prevented the suppression of hippocampal long-term potentiation induced by Aβ31-35.
In plain wordsIn rats, Rattin prevented the loss of a brain signal linked to learning that Aβ31-35 caused.
Peptide
Humanin
Outcome
DecreaseAβ31-35-induced hippocampal LTP suppression
Study
ratn: not reported in source
Aβ31-35 injection model
Comparator
Aβ31-35 without Rattin
Outcome group
Cognition and memory · Nervous system and cognition
Source sentences
Summary
We showed that intra-hippocampal injection of Rattin effectively prevented the Aβ31-35-induced spatial memory deficits and hippocampal LTP suppression in rats
2 context sentences(design, population, supporting numbers)
Summary · context
Rattin, a specific derivative of humanin in rats, shares the ability with HN to protect neurons against amyloid β (Aβ) peptide-induced cellular toxicity.
Summary · context
In the present study, we observed the effects of Rattin and Aβ31-35 on the spatial reference memory and in vivo hippocampal Long-term potentiation of rats by using Morris water maze test and hippocampal field potential recording.
In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.
Report a problemFND-2399657402
03AnimalNot a test of Humanin aloneAnimal study (in vivo)Mechanism
In rats, Rattin treatment prevented the activation of Caspase-3 in the hippocampus that Aβ31-35 induced.
In plain wordsIn rats, Rattin treatment prevented Aβ31-35 from switching on the cell-death enzyme Caspase-3 in the hippocampus.
Peptide
Humanin
Outcome
DecreaseAβ31-35-induced Caspase-3 activation in hippocampus
Study
ratn: not reported in source
Aβ31-35 injection model
Comparator
Aβ31-35 without Rattin
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
the Aβ31-35-induced activation of Caspase-3 and inhibition of STAT3 in the hippocampus were also prevented by Rattin treatment
2 context sentences(design, population, supporting numbers)
Summary · context
Rattin, a specific derivative of humanin in rats, shares the ability with HN to protect neurons against amyloid β (Aβ) peptide-induced cellular toxicity.
Summary · context
In the present study, we observed the effects of Rattin and Aβ31-35 on the spatial reference memory and in vivo hippocampal Long-term potentiation of rats by using Morris water maze test and hippocampal field potential recording.
In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.
Report a problemFND-2399657403
04AnimalNot a test of Humanin aloneAnimal study (in vivo)Mechanism
In rats, Rattin treatment prevented the inhibition of STAT3 in the hippocampus that Aβ31-35 induced.
In plain wordsIn rats, Rattin treatment prevented Aβ31-35 from switching off STAT3 in the hippocampus.
Peptide
Humanin
Outcome
DecreaseAβ31-35-induced STAT3 inhibition in hippocampus
Study
ratn: not reported in source
Aβ31-35 injection model
Comparator
Aβ31-35 without Rattin
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
the Aβ31-35-induced activation of Caspase-3 and inhibition of STAT3 in the hippocampus were also prevented by Rattin treatment
2 context sentences(design, population, supporting numbers)
Summary · context
Rattin, a specific derivative of humanin in rats, shares the ability with HN to protect neurons against amyloid β (Aβ) peptide-induced cellular toxicity.
Summary · context
In the present study, we observed the effects of Rattin and Aβ31-35 on the spatial reference memory and in vivo hippocampal Long-term potentiation of rats by using Morris water maze test and hippocampal field potential recording.
In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.
Report a problemFND-2399657404

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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