Dual trigger with combination of gonadotropin-releasing hormone agonist and human chorionic gonadotropin significantly improves the live-birth rate for normal responders in GnRH-antagonist cycles.

Lin MH, Wu FS, Lee RK, Li SH, Lin SY, Hwu YM

Fertility and sterility28 Aug 2013Cited by 110 (Europe PMC)

PMID23993928DOI10.1016/j.fertnstert.2013.07.1976PepBankPUB-23993928

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

01HumanObservational studyEfficacy outcome
In normal IVF-ICSI responders, adding triptorelin to hCG was linked to higher implantation rates than hCG alone.
In plain wordsIn normal IVF-ICSI responders, triptorelin plus hCG was linked to higher implantation rates compared with hCG alone.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseImplantation rate
Study
n = 376
Comparator
hCG alone
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
0.2 mgAs given in this study (human).
Measurements
Implantation rate
29.6%
dual trigger
Implantation rate
18.4%
hCG trigger
Source sentences
Summary
The dual trigger group demonstrated statistically significantly higher implantation (29.6% vs. 18.4%), clinical pregnancy (50.7% vs. 40.1%), and live-birth (41.3% vs. 30.4%) rates as compared with the hCG trigger group.
3 context sentences(design, population, supporting numbers)
Summary · context
Retrospective cohort study.
Summary · context
Normal responders to controlled ovarian hyperstimulation who were undergoing IVF-ICSI with a GnRH antagonist protocol.
Summary · context
Standard dosage of hCG trigger (6,500 IU of recombinant hCG) versus dual trigger (0.2 mg of triptorelin and 6,500 IU of recombinant hCG).
Report a problemFND-2399392801
02HumanObservational studyEfficacy outcome
In normal IVF-ICSI responders, adding triptorelin to hCG was linked to higher clinical pregnancy rates than hCG alone.
In plain wordsIn normal IVF-ICSI responders, triptorelin plus hCG was linked to higher pregnancy rates compared with hCG alone.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseClinical pregnancy rate
Study
n = 376
Comparator
hCG alone
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
0.2 mgAs given in this study (human).
Measurements
Clinical pregnancy rate
50.7%
dual trigger
Clinical pregnancy rate
40.1%
hCG trigger
Source sentences
Summary
The dual trigger group demonstrated statistically significantly higher implantation (29.6% vs. 18.4%), clinical pregnancy (50.7% vs. 40.1%), and live-birth (41.3% vs. 30.4%) rates as compared with the hCG trigger group.
3 context sentences(design, population, supporting numbers)
Summary · context
Retrospective cohort study.
Summary · context
Normal responders to controlled ovarian hyperstimulation who were undergoing IVF-ICSI with a GnRH antagonist protocol.
Summary · context
Standard dosage of hCG trigger (6,500 IU of recombinant hCG) versus dual trigger (0.2 mg of triptorelin and 6,500 IU of recombinant hCG).
Report a problemFND-2399392802
03HumanObservational studyEfficacy outcome
In normal IVF-ICSI responders, adding triptorelin to hCG was linked to higher live-birth rates than hCG alone.
In plain wordsIn normal IVF-ICSI responders, triptorelin plus hCG was linked to higher live-birth rates compared with hCG alone.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseLive-birth rate
Study
n = 376
Comparator
hCG alone
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
0.2 mgAs given in this study (human).
Measurements
Live-birth rate
41.3%
dual trigger
Live-birth rate
30.4%
hCG trigger
Source sentences
Summary
The dual trigger group demonstrated statistically significantly higher implantation (29.6% vs. 18.4%), clinical pregnancy (50.7% vs. 40.1%), and live-birth (41.3% vs. 30.4%) rates as compared with the hCG trigger group.
3 context sentences(design, population, supporting numbers)
Summary · context
Retrospective cohort study.
Summary · context
Normal responders to controlled ovarian hyperstimulation who were undergoing IVF-ICSI with a GnRH antagonist protocol.
Summary · context
Standard dosage of hCG trigger (6,500 IU of recombinant hCG) versus dual trigger (0.2 mg of triptorelin and 6,500 IU of recombinant hCG).
Report a problemFND-2399392803
04HumanObservational studyEfficacy outcome
In normal IVF-ICSI responders, embryo quality did not differ significantly between triptorelin plus hCG and hCG alone.
In plain wordsIn normal IVF-ICSI responders, embryo quality was similar with triptorelin plus hCG and hCG alone.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeEmbryo quality
Study
n = 376
Comparator
hCG alone
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
0.2 mgAs given in this study (human).
Source sentences
Summary
There was no statistically significant difference in terms of patient demographics, cycle parameters, or embryo quality.
3 context sentences(design, population, supporting numbers)
Summary · context
Retrospective cohort study.
Summary · context
Normal responders to controlled ovarian hyperstimulation who were undergoing IVF-ICSI with a GnRH antagonist protocol.
Summary · context
Standard dosage of hCG trigger (6,500 IU of recombinant hCG) versus dual trigger (0.2 mg of triptorelin and 6,500 IU of recombinant hCG).
Report a problemFND-2399392804