Mitochondria-targeted peptides prevent on contrast-induced acute kidney injury in the rats with hypercholesterolemia.

Duan SB, Yang SK, Zhou QY, Pan P, Zhang H, Liu F, Xu XQ

Renal failure23 Jul 2013Cited by 20 (Europe PMC)

PMID23879473DOI10.3109/0886022x.2013.815107PepBankPUB-23879473

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone8

In this study, Elamipretide (SS-31) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Elamipretide (SS-31).

01AnimalNot a test of Elamipretide (SS-31) aloneAnimal study (in vivo)Efficacy outcome
In hypercholesterolemic rats given contrast medium, pretreatment with MTP131 or SPI20 pooled decreased serum creatinine.
In plain wordsIn rats with high cholesterol given contrast dye, two mitochondria-targeted peptides together lowered serum creatinine, a kidney injury marker.
Peptide
Elamipretide (SS-31)
Outcome
DecreaseSerum creatinine
Study
ratn: not reported in source
Contrast-induced acute kidney injury with hypercholesterolemia
Comparator
Diatrizoate without pretreatment
Outcome group
Kidney function · Kidney and urinary
Source sentences
Summary
In the groups pretreated with MTP131 or SPI20, the levels of Scr, FeNa%, FeK%, MDA content and NADPH oxidase activity in renal tissue decreased (p < 0.01), the levels of renal super oxygen dehydrogenises and ATPase activity increased (p < 0.01).
2 context sentences(design, population, supporting numbers)
Summary · context
Forty SD rats were randomly divided into normal diet group (NN, n = 8) and high cholesterol supplemented dietary group (HN, n = 32).
Summary · context
All Rats were given injection of either diatrizoate (10 mL/kg) or equal volume of normal saline, the rats pretreated with MTP131 or SPI20 were given injection with MTP131 or SPI 20 (3 mg/kg) by peritoneal cavity for 3 times.
In this study, Elamipretide (SS-31) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Elamipretide (SS-31).
Report a problemFND-2387947301
02AnimalNot a test of Elamipretide (SS-31) aloneAnimal study (in vivo)Efficacy outcome
In hypercholesterolemic rats given contrast medium, pretreatment with MTP131 or SPI20 pooled decreased fractional excretion of sodium.
In plain wordsIn rats with high cholesterol given contrast dye, two mitochondria-targeted peptides together lowered sodium loss in urine.
Peptide
Elamipretide (SS-31)
Outcome
DecreaseFractional excretion of sodium
Study
ratn: not reported in source
Contrast-induced acute kidney injury with hypercholesterolemia
Comparator
Diatrizoate without pretreatment
Outcome group
Kidney function · Kidney and urinary
Source sentences
Summary
In the groups pretreated with MTP131 or SPI20, the levels of Scr, FeNa%, FeK%, MDA content and NADPH oxidase activity in renal tissue decreased (p < 0.01), the levels of renal super oxygen dehydrogenises and ATPase activity increased (p < 0.01).
2 context sentences(design, population, supporting numbers)
Summary · context
Forty SD rats were randomly divided into normal diet group (NN, n = 8) and high cholesterol supplemented dietary group (HN, n = 32).
Summary · context
All Rats were given injection of either diatrizoate (10 mL/kg) or equal volume of normal saline, the rats pretreated with MTP131 or SPI20 were given injection with MTP131 or SPI 20 (3 mg/kg) by peritoneal cavity for 3 times.
In this study, Elamipretide (SS-31) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Elamipretide (SS-31).
Report a problemFND-2387947302
03AnimalNot a test of Elamipretide (SS-31) aloneAnimal study (in vivo)Efficacy outcome
In hypercholesterolemic rats given contrast medium, pretreatment with MTP131 or SPI20 pooled decreased fractional excretion of potassium.
In plain wordsIn rats with high cholesterol given contrast dye, two mitochondria-targeted peptides together lowered potassium loss in urine.
Peptide
Elamipretide (SS-31)
Outcome
DecreaseFractional excretion of potassium
Study
ratn: not reported in source
Contrast-induced acute kidney injury with hypercholesterolemia
Comparator
Diatrizoate without pretreatment
Outcome group
Kidney function · Kidney and urinary
Source sentences
Summary
In the groups pretreated with MTP131 or SPI20, the levels of Scr, FeNa%, FeK%, MDA content and NADPH oxidase activity in renal tissue decreased (p < 0.01), the levels of renal super oxygen dehydrogenises and ATPase activity increased (p < 0.01).
2 context sentences(design, population, supporting numbers)
Summary · context
Forty SD rats were randomly divided into normal diet group (NN, n = 8) and high cholesterol supplemented dietary group (HN, n = 32).
Summary · context
All Rats were given injection of either diatrizoate (10 mL/kg) or equal volume of normal saline, the rats pretreated with MTP131 or SPI20 were given injection with MTP131 or SPI 20 (3 mg/kg) by peritoneal cavity for 3 times.
In this study, Elamipretide (SS-31) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Elamipretide (SS-31).
Report a problemFND-2387947303
04AnimalNot a test of Elamipretide (SS-31) aloneAnimal study (in vivo)Mechanism
In hypercholesterolemic rats given contrast medium, pretreatment with MTP131 or SPI20 pooled decreased renal malondialdehyde content.
In plain wordsIn rats with high cholesterol given contrast dye, two mitochondria-targeted peptides together lowered a kidney marker of oxidative damage.
Peptide
Elamipretide (SS-31)
Outcome
DecreaseRenal malondialdehyde content
Study
ratn: not reported in source
Contrast-induced acute kidney injury with hypercholesterolemia
Comparator
Diatrizoate without pretreatment
Outcome group
Oxidative stress · Kidney and urinary
Source sentences
Summary
In the groups pretreated with MTP131 or SPI20, the levels of Scr, FeNa%, FeK%, MDA content and NADPH oxidase activity in renal tissue decreased (p < 0.01), the levels of renal super oxygen dehydrogenises and ATPase activity increased (p < 0.01).
2 context sentences(design, population, supporting numbers)
Summary · context
Forty SD rats were randomly divided into normal diet group (NN, n = 8) and high cholesterol supplemented dietary group (HN, n = 32).
Summary · context
All Rats were given injection of either diatrizoate (10 mL/kg) or equal volume of normal saline, the rats pretreated with MTP131 or SPI20 were given injection with MTP131 or SPI 20 (3 mg/kg) by peritoneal cavity for 3 times.
In this study, Elamipretide (SS-31) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Elamipretide (SS-31).
Report a problemFND-2387947304
05AnimalNot a test of Elamipretide (SS-31) aloneAnimal study (in vivo)Mechanism
In hypercholesterolemic rats given contrast medium, pretreatment with MTP131 or SPI20 pooled decreased renal NADPH oxidase activity.
In plain wordsIn rats with high cholesterol given contrast dye, two mitochondria-targeted peptides together lowered kidney NADPH oxidase activity.
Peptide
Elamipretide (SS-31)
Outcome
DecreaseRenal NADPH oxidase activity
Study
ratn: not reported in source
Contrast-induced acute kidney injury with hypercholesterolemia
Comparator
Diatrizoate without pretreatment
Outcome group
Oxidative stress · Kidney and urinary
Source sentences
Summary
In the groups pretreated with MTP131 or SPI20, the levels of Scr, FeNa%, FeK%, MDA content and NADPH oxidase activity in renal tissue decreased (p < 0.01), the levels of renal super oxygen dehydrogenises and ATPase activity increased (p < 0.01).
2 context sentences(design, population, supporting numbers)
Summary · context
Forty SD rats were randomly divided into normal diet group (NN, n = 8) and high cholesterol supplemented dietary group (HN, n = 32).
Summary · context
All Rats were given injection of either diatrizoate (10 mL/kg) or equal volume of normal saline, the rats pretreated with MTP131 or SPI20 were given injection with MTP131 or SPI 20 (3 mg/kg) by peritoneal cavity for 3 times.
In this study, Elamipretide (SS-31) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Elamipretide (SS-31).
Report a problemFND-2387947305
06AnimalNot a test of Elamipretide (SS-31) aloneAnimal study (in vivo)Mechanism
In hypercholesterolemic rats given contrast medium, pretreatment with MTP131 or SPI20 pooled increased renal superoxide dismutase activity.
In plain wordsIn rats with high cholesterol given contrast dye, two mitochondria-targeted peptides together raised kidney antioxidant enzyme activity.
Peptide
Elamipretide (SS-31)
Outcome
IncreaseRenal superoxide dismutase activity
Study
ratn: not reported in source
Contrast-induced acute kidney injury with hypercholesterolemia
Comparator
Diatrizoate without pretreatment
Outcome group
Oxidative stress · Kidney and urinary
Source sentences
Summary
In the groups pretreated with MTP131 or SPI20, the levels of Scr, FeNa%, FeK%, MDA content and NADPH oxidase activity in renal tissue decreased (p < 0.01), the levels of renal super oxygen dehydrogenises and ATPase activity increased (p < 0.01).
2 context sentences(design, population, supporting numbers)
Summary · context
Forty SD rats were randomly divided into normal diet group (NN, n = 8) and high cholesterol supplemented dietary group (HN, n = 32).
Summary · context
All Rats were given injection of either diatrizoate (10 mL/kg) or equal volume of normal saline, the rats pretreated with MTP131 or SPI20 were given injection with MTP131 or SPI 20 (3 mg/kg) by peritoneal cavity for 3 times.
In this study, Elamipretide (SS-31) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Elamipretide (SS-31).
Report a problemFND-2387947306
07AnimalNot a test of Elamipretide (SS-31) aloneAnimal study (in vivo)Mechanism
In hypercholesterolemic rats given contrast medium, pretreatment with MTP131 or SPI20 pooled increased renal ATPase activity.
In plain wordsIn rats with high cholesterol given contrast dye, two mitochondria-targeted peptides together raised kidney ATPase enzyme activity.
Peptide
Elamipretide (SS-31)
Outcome
IncreaseRenal ATPase activity
Study
ratn: not reported in source
Contrast-induced acute kidney injury with hypercholesterolemia
Comparator
Diatrizoate without pretreatment
Outcome group
Mitochondrial function · Kidney and urinary
Source sentences
Summary
In the groups pretreated with MTP131 or SPI20, the levels of Scr, FeNa%, FeK%, MDA content and NADPH oxidase activity in renal tissue decreased (p < 0.01), the levels of renal super oxygen dehydrogenises and ATPase activity increased (p < 0.01).
2 context sentences(design, population, supporting numbers)
Summary · context
Forty SD rats were randomly divided into normal diet group (NN, n = 8) and high cholesterol supplemented dietary group (HN, n = 32).
Summary · context
All Rats were given injection of either diatrizoate (10 mL/kg) or equal volume of normal saline, the rats pretreated with MTP131 or SPI20 were given injection with MTP131 or SPI 20 (3 mg/kg) by peritoneal cavity for 3 times.
In this study, Elamipretide (SS-31) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Elamipretide (SS-31).
Report a problemFND-2387947307
08AnimalNot a test of Elamipretide (SS-31) aloneAnimal study (in vivo)Efficacy outcome
In hypercholesterolemic rats, pretreatment with MTP131 or SPI20 pooled alleviated renal injuries induced by contrast media.
In plain wordsIn rats with high cholesterol, two mitochondria-targeted peptides together reduced kidney injury caused by contrast dye.
Peptide
Elamipretide (SS-31)
Outcome
DecreaseContrast media-induced renal injury
Study
ratn: not reported in source
Contrast-induced acute kidney injury with hypercholesterolemia
Comparator
Diatrizoate without pretreatment
Outcome group
Kidney function · Kidney and urinary
Source sentences
Summary
The renal injuries induced by contrast media (CM) were alleviated.
2 context sentences(design, population, supporting numbers)
Summary · context
Forty SD rats were randomly divided into normal diet group (NN, n = 8) and high cholesterol supplemented dietary group (HN, n = 32).
Summary · context
All Rats were given injection of either diatrizoate (10 mL/kg) or equal volume of normal saline, the rats pretreated with MTP131 or SPI20 were given injection with MTP131 or SPI 20 (3 mg/kg) by peritoneal cavity for 3 times.
In this study, Elamipretide (SS-31) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Elamipretide (SS-31).
Report a problemFND-2387947308

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 08:19 UTC
Study results updated
Version 1
9 Oct 2026, 02:47 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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MeSH terms

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