Hexarelin treatment in male ghrelin knockout mice after myocardial infarction.

Mao Y, Tokudome T, Kishimoto I, Otani K, Hosoda H, Nagai C, Minamino N, Miyazato M, Kangawa K

Endocrinology16 Jul 2013Cited by 18 (Europe PMC)

PMID23861368DOI10.1210/en.2013-1291PepBankPUB-23861368

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In ghrelin-knockout mice after myocardial infarction, hexarelin lowered mortality within 2 weeks compared with vehicle (6.7% versus 50%).
In plain wordsIn mice with a heart attack, fewer died within 2 weeks with hexarelin than with vehicle.
Peptide
Hexarelin
Outcome
DecreaseMortality within 2 weeks
Study
mousen: not reported in source
ghrelin-knockout mice after myocardial infarction
Comparator
Vehicle
Outcome group
Mortality · Cardiovascular
Studied dose
400 nmol/kg/d · subcutaneous · 2 weeksAs given in this study (mouse).
Measurements
Mortality
6.7%
hexarelin
Mortality
50%
vehicle
Source sentences
Summary
The mortality within 2 weeks was significantly lower in the hexarelin group (6.7%) and ghrelin group (14.3%) than in the vehicle group (50%) (P < .05).
2 context sentences(design, population, supporting numbers)
Summary · context
This study aimed to clarify whether hexarelin treatment can compensate for ghrelin deficiency in ghrelin-knockout mice and to compare the effects of hexarelin (400 nmol/kg/d, sc) and equimolar ghrelin treatment after myocardial infarction.
Summary · context
Myocardial infarction was produced by left coronary artery ligation in male ghrelin-knockout mice, which then received ghrelin, hexarelin, or vehicle treatment for 2 weeks.
Report a problemFND-2386136801
02AnimalAnimal study (in vivo)Efficacy outcome
In ghrelin-knockout mice 2 weeks after myocardial infarction, hexarelin gave greater cardiac output than vehicle.
In plain wordsIn mice 2 weeks after a heart attack, hexarelin gave a higher heart output than vehicle.
Peptide
Hexarelin
Outcome
IncreaseCardiac output
Study
mousen: not reported in source
ghrelin-knockout mice after myocardial infarction
Comparator
Vehicle
Outcome group
Heart function · Cardiovascular
Studied dose
400 nmol/kg/d · subcutaneous · 2 weeksAs given in this study (mouse).
Source sentences
Summary
A comparison of cardiac function 2 weeks after infarction showed that in the ghrelin and hexarelin treatment groups, cardiac output was greater, whereas systolic function, represented by ejection fraction, and diastolic function, represented by dP/dt min (peak rate of pressure decline), were signifi…
2 context sentences(design, population, supporting numbers)
Summary · context
This study aimed to clarify whether hexarelin treatment can compensate for ghrelin deficiency in ghrelin-knockout mice and to compare the effects of hexarelin (400 nmol/kg/d, sc) and equimolar ghrelin treatment after myocardial infarction.
Summary · context
Myocardial infarction was produced by left coronary artery ligation in male ghrelin-knockout mice, which then received ghrelin, hexarelin, or vehicle treatment for 2 weeks.
Report a problemFND-2386136802
03AnimalAnimal study (in vivo)Efficacy outcome
In ghrelin-knockout mice 2 weeks after myocardial infarction, hexarelin gave a significantly higher ejection fraction than vehicle.
In plain wordsIn mice 2 weeks after a heart attack, hexarelin gave better pumping function than vehicle.
Peptide
Hexarelin
Outcome
IncreaseEjection fraction (systolic function)
Study
mousen: not reported in source
ghrelin-knockout mice after myocardial infarction
Comparator
Vehicle
Outcome group
Heart function · Cardiovascular
Studied dose
400 nmol/kg/d · subcutaneous · 2 weeksAs given in this study (mouse).
Source sentences
Summary
A comparison of cardiac function 2 weeks after infarction showed that in the ghrelin and hexarelin treatment groups, cardiac output was greater, whereas systolic function, represented by ejection fraction, and diastolic function, represented by dP/dt min (peak rate of pressure decline), were signifi…
2 context sentences(design, population, supporting numbers)
Summary · context
This study aimed to clarify whether hexarelin treatment can compensate for ghrelin deficiency in ghrelin-knockout mice and to compare the effects of hexarelin (400 nmol/kg/d, sc) and equimolar ghrelin treatment after myocardial infarction.
Summary · context
Myocardial infarction was produced by left coronary artery ligation in male ghrelin-knockout mice, which then received ghrelin, hexarelin, or vehicle treatment for 2 weeks.
Report a problemFND-2386136803
04AnimalAnimal study (in vivo)Efficacy outcome
In ghrelin-knockout mice 2 weeks after myocardial infarction, diastolic function by dP/dt min was significantly better with hexarelin than with vehicle.
In plain wordsIn mice 2 weeks after a heart attack, hexarelin gave better heart relaxation than vehicle.
Peptide
Hexarelin
Outcome
IncreaseDiastolic function (dP/dt min)
Study
mousen: not reported in source
ghrelin-knockout mice after myocardial infarction
Comparator
Vehicle
Outcome group
Heart function · Cardiovascular
Studied dose
400 nmol/kg/d · subcutaneous · 2 weeksAs given in this study (mouse).
Source sentences
Summary
A comparison of cardiac function 2 weeks after infarction showed that in the ghrelin and hexarelin treatment groups, cardiac output was greater, whereas systolic function, represented by ejection fraction, and diastolic function, represented by dP/dt min (peak rate of pressure decline), were signifi…
2 context sentences(design, population, supporting numbers)
Summary · context
This study aimed to clarify whether hexarelin treatment can compensate for ghrelin deficiency in ghrelin-knockout mice and to compare the effects of hexarelin (400 nmol/kg/d, sc) and equimolar ghrelin treatment after myocardial infarction.
Summary · context
Myocardial infarction was produced by left coronary artery ligation in male ghrelin-knockout mice, which then received ghrelin, hexarelin, or vehicle treatment for 2 weeks.
Report a problemFND-2386136804
05AnimalAnimal study (in vivo)Efficacy outcome
In ghrelin-knockout mice after myocardial infarction, hexarelin raised ejection fraction more than equimolar ghrelin.
In plain wordsIn mice after a heart attack, hexarelin improved pumping function more than ghrelin.
Peptide
Hexarelin
Outcome
IncreaseEjection fraction versus ghrelin
Study
mousen: not reported in source
ghrelin-knockout mice after myocardial infarction
Comparator
Ghrelin
Outcome group
Heart function · Cardiovascular
Studied dose
400 nmol/kg/d · subcutaneous · 2 weeksAs given in this study (mouse).
Source sentences
Summary
Hexarelin treatment was more effective than ghrelin treatment, as indicated by the ejection fraction, dP/dt max (peak rate of pressure rise), and dP/dt min.
2 context sentences(design, population, supporting numbers)
Summary · context
This study aimed to clarify whether hexarelin treatment can compensate for ghrelin deficiency in ghrelin-knockout mice and to compare the effects of hexarelin (400 nmol/kg/d, sc) and equimolar ghrelin treatment after myocardial infarction.
Summary · context
Myocardial infarction was produced by left coronary artery ligation in male ghrelin-knockout mice, which then received ghrelin, hexarelin, or vehicle treatment for 2 weeks.
Report a problemFND-2386136805
06AnimalAnimal study (in vivo)Efficacy outcome
In ghrelin-knockout mice after myocardial infarction, hexarelin was more effective than ghrelin on dP/dt max.
In plain wordsIn mice after a heart attack, hexarelin improved the heart's pressure rise rate more than ghrelin.
Peptide
Hexarelin
Outcome
IncreasedP/dt max versus ghrelin
Study
mousen: not reported in source
ghrelin-knockout mice after myocardial infarction
Comparator
Ghrelin
Outcome group
Heart function · Cardiovascular
Studied dose
400 nmol/kg/d · subcutaneous · 2 weeksAs given in this study (mouse).
Source sentences
Summary
Hexarelin treatment was more effective than ghrelin treatment, as indicated by the ejection fraction, dP/dt max (peak rate of pressure rise), and dP/dt min.
2 context sentences(design, population, supporting numbers)
Summary · context
This study aimed to clarify whether hexarelin treatment can compensate for ghrelin deficiency in ghrelin-knockout mice and to compare the effects of hexarelin (400 nmol/kg/d, sc) and equimolar ghrelin treatment after myocardial infarction.
Summary · context
Myocardial infarction was produced by left coronary artery ligation in male ghrelin-knockout mice, which then received ghrelin, hexarelin, or vehicle treatment for 2 weeks.
Report a problemFND-2386136806
07AnimalAnimal study (in vivo)Efficacy outcome
In ghrelin-knockout mice after myocardial infarction, hexarelin was more effective than ghrelin on dP/dt min.
In plain wordsIn mice after a heart attack, hexarelin improved the heart's pressure decline rate more than ghrelin.
Peptide
Hexarelin
Outcome
IncreasedP/dt min versus ghrelin
Study
mousen: not reported in source
ghrelin-knockout mice after myocardial infarction
Comparator
Ghrelin
Outcome group
Heart function · Cardiovascular
Studied dose
400 nmol/kg/d · subcutaneous · 2 weeksAs given in this study (mouse).
Source sentences
Summary
Hexarelin treatment was more effective than ghrelin treatment, as indicated by the ejection fraction, dP/dt max (peak rate of pressure rise), and dP/dt min.
2 context sentences(design, population, supporting numbers)
Summary · context
This study aimed to clarify whether hexarelin treatment can compensate for ghrelin deficiency in ghrelin-knockout mice and to compare the effects of hexarelin (400 nmol/kg/d, sc) and equimolar ghrelin treatment after myocardial infarction.
Summary · context
Myocardial infarction was produced by left coronary artery ligation in male ghrelin-knockout mice, which then received ghrelin, hexarelin, or vehicle treatment for 2 weeks.
Report a problemFND-2386136807
08AnimalAnimal study (in vivo)Efficacy outcome
In ghrelin-knockout mice after myocardial infarction, hexarelin clearly suppressed sympathetic nervous activity relative to vehicle.
In plain wordsIn mice after a heart attack, hexarelin lowered sympathetic nerve activity compared with vehicle.
Peptide
Hexarelin
Outcome
DecreaseSympathetic nervous activity
Study
mousen: not reported in source
ghrelin-knockout mice after myocardial infarction
Comparator
Vehicle
Outcome group
Heart function · Cardiovascular
Studied dose
400 nmol/kg/d · subcutaneous · 2 weeksAs given in this study (mouse).
Source sentences
Summary
Telemetry recording and heart rate variability analysis demonstrated that sympathetic nervous activity was clearly suppressed in the hexarelin and ghrelin groups relative to the vehicle group.
2 context sentences(design, population, supporting numbers)
Summary · context
This study aimed to clarify whether hexarelin treatment can compensate for ghrelin deficiency in ghrelin-knockout mice and to compare the effects of hexarelin (400 nmol/kg/d, sc) and equimolar ghrelin treatment after myocardial infarction.
Summary · context
Myocardial infarction was produced by left coronary artery ligation in male ghrelin-knockout mice, which then received ghrelin, hexarelin, or vehicle treatment for 2 weeks.
Report a problemFND-2386136808
09AnimalAnimal study (in vivo)Efficacy outcome
In ghrelin-knockout mice after myocardial infarction, hexarelin and ghrelin had similar effects on mortality.
In plain wordsIn mice after a heart attack, hexarelin and ghrelin had similar effects on death rates.
Peptide
Hexarelin
Outcome
No significant changeMortality versus ghrelin
Study
mousen: not reported in source
ghrelin-knockout mice after myocardial infarction
Comparator
Ghrelin
Outcome group
Mortality · Cardiovascular
Studied dose
400 nmol/kg/d · subcutaneous · 2 weeksAs given in this study (mouse).
Source sentences
Summary
both hormones have similar effects on heart rate variability and mortality.
3 context sentences(design, population, supporting numbers)
Summary · context
The mortality within 2 weeks was significantly lower in the hexarelin group (6.7%) and ghrelin group (14.3%) than in the vehicle group (50%) (P < .05).
Summary · context
This study aimed to clarify whether hexarelin treatment can compensate for ghrelin deficiency in ghrelin-knockout mice and to compare the effects of hexarelin (400 nmol/kg/d, sc) and equimolar ghrelin treatment after myocardial infarction.
Summary · context
Myocardial infarction was produced by left coronary artery ligation in male ghrelin-knockout mice, which then received ghrelin, hexarelin, or vehicle treatment for 2 weeks.
Report a problemFND-2386136809
10AnimalAnimal study (in vivo)Efficacy outcome
In ghrelin-knockout mice after myocardial infarction, hexarelin and ghrelin had similar effects on heart rate variability.
In plain wordsIn mice after a heart attack, hexarelin and ghrelin had similar effects on heart rate variability.
Peptide
Hexarelin
Outcome
No significant changeHeart rate variability versus ghrelin
Study
mousen: not reported in source
ghrelin-knockout mice after myocardial infarction
Comparator
Ghrelin
Outcome group
Heart function · Cardiovascular
Studied dose
400 nmol/kg/d · subcutaneous · 2 weeksAs given in this study (mouse).
Source sentences
Summary
both hormones have similar effects on heart rate variability and mortality.
2 context sentences(design, population, supporting numbers)
Summary · context
This study aimed to clarify whether hexarelin treatment can compensate for ghrelin deficiency in ghrelin-knockout mice and to compare the effects of hexarelin (400 nmol/kg/d, sc) and equimolar ghrelin treatment after myocardial infarction.
Summary · context
Myocardial infarction was produced by left coronary artery ligation in male ghrelin-knockout mice, which then received ghrelin, hexarelin, or vehicle treatment for 2 weeks.
Report a problemFND-2386136810

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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