In isolated male rat skeletal muscle fibers, hexarelin did not significantly change resting cytosolic calcium, unlike the nonpeptidyl growth hormone secretagogues.
In plain wordsIn lab tests on rat muscle fibers, hexarelin did not change resting calcium levels, while nonpeptidyl growth hormone secretagogues raised them.
- Peptide
- Hexarelin
- Outcome
- No significant changeResting cytosolic calcium
- Study
ratn: not reported in source
isolated tendon-to-tendon male rat skeletal muscle fibers- Outcome group
- Receptor activity and mechanism · Musculoskeletal
- Studied dose
- Dose not stated
Source sentences
The synthetic nonpeptidyl GHSs, but not peptidyl ghrelin and hexarelin, were able to significantly increase resting cytosolic calcium [Ca²⁺]i.
1 context sentence(design, population, supporting numbers)
By using fura-2 cytofluorimetric technique, we determined the acute effects of ghrelin, as well as of peptidyl and nonpeptidyl synthetic GHSs on calcium homeostasis, a critical biomarker of muscle function, in isolated tendon-to-tendon male rat skeletal muscle fibers.