Skip to content

Study · Non-randomized trial · n = 60 · 2013

3 results

Effects of simvastatin in prevention of pain recurrences after surgery for endometriosis.

Almassinokiani F, Mehdizadeh A, Sariri E, Rezaei M, Almasi A, Akbari H, Pazooki A, Solaymani-Dodaran M, Asadollah S, Amirkhani J, Chaichian S, Vahdat M, Moosavi A, Ashouri M, Tamannaei Z

Medical science monitor : international medical journal of experimental and clinical research5 Jul 2013Cited by 40 (Europe PMC)

PMID23828228 (opens in a new tab)PMCIDPMC3706410 (opens in a new tab)DOI10.12659/msm.883967 (opens in a new tab)PepBankPUB-23828228
Source linkPubMedAsk about this study
Jump to 3 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In women after endometriosis surgery, dyspareunia decreased in both groups, with no significant difference between Decapeptyl and simvastatin.

    In plain wordsIn women after endometriosis surgery, pain during sex improved similarly with Decapeptyl and simvastatin.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    No significant changeDyspareunia
    Study

    n = 60

    Comparator
    simvastatin
    Outcome group
    Pain · Reproductive and sexual health
    Studied dose
    3.75 mg every 4 weeks for 4 dosesAs given in this study (human).

    Source sentences

    Summary
    Using VAS, the score of dyspareunia, dysmenorrhea, and pelvic pain 6 months after laparoscopic surgery declined significantly in both groups (p=0.001), but the difference between results of the 2 groups was not significant (p>0.05).
    2 context sentences
    Summary · context
    To compare efficacy of simvastatin with GnRHa (Decapeptyl 3.75 mg) on endometriosis-related pains following surgery for endometriosis.
    Summary · context
    Sixty women with pelvic endometriosis, after laparoscopic diagnosis and conservative laparoscopic surgery, were treated with either simvastatin (n=30) for 16 weeks or Decapeptyl (n=30) every 4 weeks for 4 doses.
  2. 02HumanNon-randomized trialEfficacy outcome

    In women after endometriosis surgery, dysmenorrhea decreased in both groups, with no significant difference between Decapeptyl and simvastatin.

    In plain wordsIn women after endometriosis surgery, menstrual pain improved similarly with Decapeptyl and simvastatin.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    No significant changeDysmenorrhea
    Study

    n = 60

    Comparator
    simvastatin
    Outcome group
    Pain · Reproductive and sexual health
    Studied dose
    3.75 mg every 4 weeks for 4 dosesAs given in this study (human).

    Source sentences

    Summary
    Using VAS, the score of dyspareunia, dysmenorrhea, and pelvic pain 6 months after laparoscopic surgery declined significantly in both groups (p=0.001), but the difference between results of the 2 groups was not significant (p>0.05).
    2 context sentences
    Summary · context
    To compare efficacy of simvastatin with GnRHa (Decapeptyl 3.75 mg) on endometriosis-related pains following surgery for endometriosis.
    Summary · context
    Sixty women with pelvic endometriosis, after laparoscopic diagnosis and conservative laparoscopic surgery, were treated with either simvastatin (n=30) for 16 weeks or Decapeptyl (n=30) every 4 weeks for 4 doses.
  3. 03HumanNon-randomized trialEfficacy outcome

    In women after endometriosis surgery, pelvic pain decreased in both groups, with no significant difference between Decapeptyl and simvastatin.

    In plain wordsIn women after endometriosis surgery, pelvic pain improved similarly with Decapeptyl and simvastatin.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    No significant changePelvic pain
    Study

    n = 60

    Comparator
    simvastatin
    Outcome group
    Pain · Reproductive and sexual health
    Studied dose
    3.75 mg every 4 weeks for 4 dosesAs given in this study (human).

    Source sentences

    Summary
    Using VAS, the score of dyspareunia, dysmenorrhea, and pelvic pain 6 months after laparoscopic surgery declined significantly in both groups (p=0.001), but the difference between results of the 2 groups was not significant (p>0.05).
    2 context sentences
    Summary · context
    To compare efficacy of simvastatin with GnRHa (Decapeptyl 3.75 mg) on endometriosis-related pains following surgery for endometriosis.
    Summary · context
    Sixty women with pelvic endometriosis, after laparoscopic diagnosis and conservative laparoscopic surgery, were treated with either simvastatin (n=30) for 16 weeks or Decapeptyl (n=30) every 4 weeks for 4 doses.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.