Increased thymosin β4 levels in the serum and SF of knee osteoarthritis patients correlate with disease severity.

Wei M, Duan D, Liu Y, Wang Z, Li Z

Regulatory peptides28 Jun 2013Cited by 12 (Europe PMC)

PMID23816466DOI10.1016/j.regpep.2013.06.011PepBankPUB-23816466

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

No result from this study comes from a test of the peptide.

Natural levels measured6

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01HumanEndogenous levelObservational studyOther
In adults, patients with knee osteoarthritis had higher serum levels of the body's own Tβ4 than healthy controls.
In plain wordsAdults with knee osteoarthritis had higher levels of the body's own Tβ4 in blood than healthy adults.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseSerum Tβ4 in knee OA versus healthy controls
Study
n = 368
Comparator
Healthy controls
Outcome group
Endogenous peptide levels · Musculoskeletal
Source sentences
Summary
The knee OA patients had higher levels of serum thymosin β4 than the healthy controls.
1 context sentence(design, population, supporting numbers)
Summary · context
This study consisted of 216 patients with knee OA and 152 healthy controls.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2381646601
02HumanEndogenous levelObservational studyOther
In patients with knee osteoarthritis, serum Tβ4 levels correlated significantly with radiographic disease severity by KL grade.
In plain wordsIn people with knee osteoarthritis, higher levels of the body's own Tβ4 in blood were linked to more severe X-ray grades.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseCorrelation of serum Tβ4 with KL grade
Study
n = 216
Outcome group
Endogenous peptide levels · Musculoskeletal
Source sentences
Summary
Thymosin β4 levels in the serum and SF of knee OA patients were significantly correlated with disease severity according to KL grading criteria.
1 context sentence(design, population, supporting numbers)
Summary · context
This study consisted of 216 patients with knee OA and 152 healthy controls.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2381646605
03HumanEndogenous levelObservational studyOther
In patients with knee osteoarthritis, serum Tβ4 was significantly higher in KL grade 4 than in KL grades 2 and 3.
In plain wordsIn people with knee osteoarthritis, the body's own Tβ4 in blood was higher in the most severe X-ray grade than in milder grades.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseSerum Tβ4 by Kellgren-Lawrence grade (grade 4 versus grades 2 and 3)
Study
n: not reported in source
Comparator
KL grades 2 and 3
Outcome group
Endogenous peptide levels · Musculoskeletal
Source sentences
Summary
Knee OA patients with KL grade 4 showed significantly elevated thymosin β4 levels in the serum and SF compared with those with KL grades 2 and 3.
1 context sentence(design, population, supporting numbers)
Summary · context
This study consisted of 216 patients with knee OA and 152 healthy controls.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2381646602
04HumanEndogenous levelObservational studyOther
In patients with knee osteoarthritis, synovial fluid Tβ4 was significantly higher in KL grade 4 than in KL grades 2 and 3.
In plain wordsIn people with knee osteoarthritis, the body's own Tβ4 in joint fluid was higher in the most severe X-ray grade than in milder grades.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseSynovial fluid Tβ4 by Kellgren-Lawrence grade (grade 4 versus grades 2 and 3)
Study
n: not reported in source
Comparator
KL grades 2 and 3
Outcome group
Endogenous peptide levels · Musculoskeletal
Source sentences
Summary
Knee OA patients with KL grade 4 showed significantly elevated thymosin β4 levels in the serum and SF compared with those with KL grades 2 and 3.
1 context sentence(design, population, supporting numbers)
Summary · context
This study consisted of 216 patients with knee OA and 152 healthy controls.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2381646603
05HumanEndogenous levelObservational studyOther
In patients with knee osteoarthritis, synovial fluid Tβ4 was significantly higher in KL grade 3 than in KL grade 2.
In plain wordsIn people with knee osteoarthritis, the body's own Tβ4 in joint fluid was higher in grade 3 than in grade 2.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseSynovial fluid Tβ4, KL grade 3 versus grade 2
Study
n: not reported in source
Comparator
KL grade 2
Outcome group
Endogenous peptide levels · Musculoskeletal
Source sentences
Summary
Knee OA patients with KL grade 3 had significantly higher SF levels of thymosin β4 than those with KL grade 2.
1 context sentence(design, population, supporting numbers)
Summary · context
This study consisted of 216 patients with knee OA and 152 healthy controls.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2381646604
06HumanEndogenous levelObservational studyOther
In patients with knee osteoarthritis, synovial fluid Tβ4 levels correlated significantly with radiographic disease severity by KL grade.
In plain wordsIn people with knee osteoarthritis, higher levels of the body's own Tβ4 in joint fluid were linked to more severe X-ray grades.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseCorrelation of synovial fluid Tβ4 with KL grade
Study
n: not reported in source
Outcome group
Endogenous peptide levels · Musculoskeletal
Source sentences
Summary
Thymosin β4 levels in the serum and SF of knee OA patients were significantly correlated with disease severity according to KL grading criteria.
1 context sentence(design, population, supporting numbers)
Summary · context
This study consisted of 216 patients with knee OA and 152 healthy controls.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2381646606

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 01:52 UTC
Study results updated
Version 1
12 Oct 2026, 18:17 UTC
First added · source update from Europe PMC

Subjects

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