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Study · Animal study (in vivo) · rabbit · 2013

14 results

Modulation of testicular and whole blood trace element concentrations in conjunction with testosterone release following kisspeptin administration in male rabbits (Oryctolagus cuniculus).

Qureshi IZ, Abbas Q

Biological trace element research30 Jun 2013Cited by 4 (Europe PMC)

PMID23812650 (opens in a new tab)DOI10.1007/s12011-013-9720-x (opens in a new tab)PepBankPUB-23812650
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study14

13 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In male rabbits, a single 1 µg kisspeptin‑10 dose increased testicular zinc at 24 h.

    In plain wordsIn male rabbits, kisspeptin‑10 raised zinc in the testes at 24 hours.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseTesticular zinc
    Study

    rabbitn: not reported in source

    Male rabbits (Oryctolagus cuniculus)
    Outcome group
    Hormone levels · Reproductive and sexual health
    Studied dose
    1 µg · intravenous · single doseAs given in this study (rabbit).

    Source sentences

    Summary
    In testes, zinc (Zn), manganese (Mn), and Fe concentrations showed significant increases at 24 h, while copper (Cu) concentration was found elevated at 4 and 24 h both (P < 0.001).
    1 context sentence
    Summary · context
    Groups of rabbits were exposed to single 1 μg kisspeptin dose (i.v., saphenous vein), while simultaneous groups were pretreated with a kisspeptin antagonist, peptide-234 (50 μg) 20 min before administering kisspeptin.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In male rabbits, a single 1 µg kisspeptin‑10 dose increased testicular manganese at 24 h.

    In plain wordsIn male rabbits, kisspeptin‑10 raised manganese in the testes at 24 hours.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseTesticular manganese
    Study

    rabbitn: not reported in source

    Male rabbits (Oryctolagus cuniculus)
    Outcome group
    Hormone levels · Reproductive and sexual health
    Studied dose
    1 µg · intravenous · single doseAs given in this study (rabbit).

    Source sentences

    Summary
    In testes, zinc (Zn), manganese (Mn), and Fe concentrations showed significant increases at 24 h, while copper (Cu) concentration was found elevated at 4 and 24 h both (P < 0.001).
    1 context sentence
    Summary · context
    Groups of rabbits were exposed to single 1 μg kisspeptin dose (i.v., saphenous vein), while simultaneous groups were pretreated with a kisspeptin antagonist, peptide-234 (50 μg) 20 min before administering kisspeptin.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In male rabbits, a single 1 µg kisspeptin‑10 dose increased testicular iron at 24 h.

    In plain wordsIn male rabbits, kisspeptin‑10 raised iron in the testes at 24 hours.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseTesticular iron
    Study

    rabbitn: not reported in source

    Male rabbits (Oryctolagus cuniculus)
    Outcome group
    Hormone levels · Reproductive and sexual health
    Studied dose
    1 µg · intravenous · single doseAs given in this study (rabbit).

    Source sentences

    Summary
    In testes, zinc (Zn), manganese (Mn), and Fe concentrations showed significant increases at 24 h, while copper (Cu) concentration was found elevated at 4 and 24 h both (P < 0.001).
    1 context sentence
    Summary · context
    Groups of rabbits were exposed to single 1 μg kisspeptin dose (i.v., saphenous vein), while simultaneous groups were pretreated with a kisspeptin antagonist, peptide-234 (50 μg) 20 min before administering kisspeptin.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In male rabbits, a single 1 µg kisspeptin‑10 dose increased testicular copper at 4 and 24 h.

    In plain wordsIn male rabbits, kisspeptin‑10 raised copper in the testes at 4 and 24 hours.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseTesticular copper
    Study

    rabbitn: not reported in source

    Male rabbits (Oryctolagus cuniculus)
    Outcome group
    Hormone levels · Reproductive and sexual health
    Studied dose
    1 µg · intravenous · single doseAs given in this study (rabbit).

    Source sentences

    Summary
    In testes, zinc (Zn), manganese (Mn), and Fe concentrations showed significant increases at 24 h, while copper (Cu) concentration was found elevated at 4 and 24 h both (P < 0.001).
    1 context sentence
    Summary · context
    Groups of rabbits were exposed to single 1 μg kisspeptin dose (i.v., saphenous vein), while simultaneous groups were pretreated with a kisspeptin antagonist, peptide-234 (50 μg) 20 min before administering kisspeptin.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In male rabbits, a single 1 µg kisspeptin‑10 dose increased whole-blood zinc at 4 and 24 h.

    In plain wordsIn male rabbits, kisspeptin‑10 raised zinc in the blood at 4 and 24 hours.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseWhole blood zinc
    Study

    rabbitn: not reported in source

    Male rabbits (Oryctolagus cuniculus)
    Outcome group
    Hormone levels · Reproductive and sexual health
    Studied dose
    1 µg · intravenous · single doseAs given in this study (rabbit).

    Source sentences

    Summary
    In whole blood, Zn and Cu concentrations were significantly elevated at 4 and 24 h, while Mn and cobalt (Co) concentrations showed increases only at 24 h (P < 0.001).
    1 context sentence
    Summary · context
    Groups of rabbits were exposed to single 1 μg kisspeptin dose (i.v., saphenous vein), while simultaneous groups were pretreated with a kisspeptin antagonist, peptide-234 (50 μg) 20 min before administering kisspeptin.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In male rabbits, a single 1 µg kisspeptin‑10 dose increased whole-blood copper at 4 and 24 h.

    In plain wordsIn male rabbits, kisspeptin‑10 raised copper in the blood at 4 and 24 hours.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseWhole blood copper
    Study

    rabbitn: not reported in source

    Male rabbits (Oryctolagus cuniculus)
    Outcome group
    Hormone levels · Reproductive and sexual health
    Studied dose
    1 µg · intravenous · single doseAs given in this study (rabbit).

    Source sentences

    Summary
    In whole blood, Zn and Cu concentrations were significantly elevated at 4 and 24 h, while Mn and cobalt (Co) concentrations showed increases only at 24 h (P < 0.001).
    1 context sentence
    Summary · context
    Groups of rabbits were exposed to single 1 μg kisspeptin dose (i.v., saphenous vein), while simultaneous groups were pretreated with a kisspeptin antagonist, peptide-234 (50 μg) 20 min before administering kisspeptin.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In male rabbits, a single 1 µg kisspeptin‑10 dose increased whole-blood manganese at 24 h only.

    In plain wordsIn male rabbits, kisspeptin‑10 raised manganese in the blood at 24 hours only.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseWhole blood manganese
    Study

    rabbitn: not reported in source

    Male rabbits (Oryctolagus cuniculus)
    Outcome group
    Hormone levels · Reproductive and sexual health
    Studied dose
    1 µg · intravenous · single doseAs given in this study (rabbit).

    Source sentences

    Summary
    In whole blood, Zn and Cu concentrations were significantly elevated at 4 and 24 h, while Mn and cobalt (Co) concentrations showed increases only at 24 h (P < 0.001).
    1 context sentence
    Summary · context
    Groups of rabbits were exposed to single 1 μg kisspeptin dose (i.v., saphenous vein), while simultaneous groups were pretreated with a kisspeptin antagonist, peptide-234 (50 μg) 20 min before administering kisspeptin.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In male rabbits, a single 1 µg kisspeptin‑10 dose increased whole-blood cobalt at 24 h only.

    In plain wordsIn male rabbits, kisspeptin‑10 raised cobalt in the blood at 24 hours only.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseWhole blood cobalt
    Study

    rabbitn: not reported in source

    Male rabbits (Oryctolagus cuniculus)
    Outcome group
    Hormone levels · Reproductive and sexual health
    Studied dose
    1 µg · intravenous · single doseAs given in this study (rabbit).

    Source sentences

    Summary
    In whole blood, Zn and Cu concentrations were significantly elevated at 4 and 24 h, while Mn and cobalt (Co) concentrations showed increases only at 24 h (P < 0.001).
    1 context sentence
    Summary · context
    Groups of rabbits were exposed to single 1 μg kisspeptin dose (i.v., saphenous vein), while simultaneous groups were pretreated with a kisspeptin antagonist, peptide-234 (50 μg) 20 min before administering kisspeptin.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In male rabbits, a single 1 µg kisspeptin‑10 dose did not change whole-blood iron.

    In plain wordsIn male rabbits, kisspeptin‑10 did not change iron in the blood.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeWhole blood iron
    Study

    rabbitn: not reported in source

    Male rabbits (Oryctolagus cuniculus)
    Outcome group
    Hormone levels · Reproductive and sexual health
    Studied dose
    1 µg · intravenous · single doseAs given in this study (rabbit).

    Source sentences

    Summary
    Blood iron concentration was not altered in the blood.
    1 context sentence
    Summary · context
    Groups of rabbits were exposed to single 1 μg kisspeptin dose (i.v., saphenous vein), while simultaneous groups were pretreated with a kisspeptin antagonist, peptide-234 (50 μg) 20 min before administering kisspeptin.
  10. 10AnimalAnimal study (in vivo)Efficacy outcome

    In male rabbits, a single 1 µg kisspeptin‑10 dose did not change testicular cobalt.

    In plain wordsIn male rabbits, kisspeptin‑10 did not change cobalt in the testes.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeTesticular cobalt
    Study

    rabbitn: not reported in source

    Male rabbits (Oryctolagus cuniculus)
    Outcome group
    Hormone levels · Reproductive and sexual health
    Studied dose
    1 µg · intravenous · single doseAs given in this study (rabbit).

    Source sentences

    Summary
    In contrast, no change occurred in testicular Co, and chromium or nickel concentrations in either testes or blood.
    1 context sentence
    Summary · context
    Groups of rabbits were exposed to single 1 μg kisspeptin dose (i.v., saphenous vein), while simultaneous groups were pretreated with a kisspeptin antagonist, peptide-234 (50 μg) 20 min before administering kisspeptin.
  11. 11AnimalAnimal study (in vivo)Efficacy outcome

    In male rabbits, a single 1 µg kisspeptin‑10 dose did not change chromium in testes or blood.

    In plain wordsIn male rabbits, kisspeptin‑10 did not change chromium in the testes or blood.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeChromium in testes and blood
    Study

    rabbitn: not reported in source

    Male rabbits (Oryctolagus cuniculus)
    Outcome group
    Hormone levels · Reproductive and sexual health
    Studied dose
    1 µg · intravenous · single doseAs given in this study (rabbit).

    Source sentences

    Summary
    In contrast, no change occurred in testicular Co, and chromium or nickel concentrations in either testes or blood.
    1 context sentence
    Summary · context
    Groups of rabbits were exposed to single 1 μg kisspeptin dose (i.v., saphenous vein), while simultaneous groups were pretreated with a kisspeptin antagonist, peptide-234 (50 μg) 20 min before administering kisspeptin.
  12. 12AnimalAnimal study (in vivo)Efficacy outcome

    In male rabbits, a single 1 µg kisspeptin‑10 dose did not change nickel in testes or blood.

    In plain wordsIn male rabbits, kisspeptin‑10 did not change nickel in the testes or blood.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeNickel in testes and blood
    Study

    rabbitn: not reported in source

    Male rabbits (Oryctolagus cuniculus)
    Outcome group
    Hormone levels · Reproductive and sexual health
    Studied dose
    1 µg · intravenous · single doseAs given in this study (rabbit).

    Source sentences

    Summary
    In contrast, no change occurred in testicular Co, and chromium or nickel concentrations in either testes or blood.
    1 context sentence
    Summary · context
    Groups of rabbits were exposed to single 1 μg kisspeptin dose (i.v., saphenous vein), while simultaneous groups were pretreated with a kisspeptin antagonist, peptide-234 (50 μg) 20 min before administering kisspeptin.
  13. 13AnimalAnimal study (in vivo)Efficacy outcome

    In male rabbits, a single 1 µg kisspeptin‑10 dose increased serum testosterone gradually, with a peak at 2 h, then it declined.

    In plain wordsIn male rabbits, kisspeptin‑10 raised testosterone, which peaked at 2 hours and then fell, compared with control and predose levels.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseSerum testosterone over 24 h
    Study

    rabbitn: not reported in source

    Male rabbits (Oryctolagus cuniculus)
    Comparator
    Control and predose groups
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    1 µg · intravenous · single doseAs given in this study (rabbit).

    Source sentences

    Summary
    Compared to control and predose groups, serum testosterone levels increased gradually and peaked at 2 h (P < 0.001) post kisspeptin treatment but declined thereafter.
    1 context sentence
    Summary · context
    Groups of rabbits were exposed to single 1 μg kisspeptin dose (i.v., saphenous vein), while simultaneous groups were pretreated with a kisspeptin antagonist, peptide-234 (50 μg) 20 min before administering kisspeptin.

Studies that did not test the peptide alone1

In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Kisspeptin-10.

  1. 14AnimalNot a test of Kisspeptin-10 aloneAnimal study (in vivo)Mechanism

    In male rabbits, pretreatment with the kisspeptin antagonist peptide-234 abolished the kisspeptin-induced increases in trace elements and testosterone.

    In plain wordsIn male rabbits, a kisspeptin blocker stopped the rise in trace elements and testosterone that kisspeptin caused.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseAntagonist pretreatment on kisspeptin-induced increases
    Study

    rabbitn: not reported in source

    Male rabbits (Oryctolagus cuniculus)
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health

    Source sentences

    Summary
    Pretreatment with antagonist abolished all increases in trace elements and testosterone concentrations.
    1 context sentence
    Summary · context
    Groups of rabbits were exposed to single 1 μg kisspeptin dose (i.v., saphenous vein), while simultaneous groups were pretreated with a kisspeptin antagonist, peptide-234 (50 μg) 20 min before administering kisspeptin.

    In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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