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Study · Animal study (in vivo) · rhesus monkey · 2014

4 results

Intratesticular action of kisspeptin in rhesus monkey (Macaca mulatta).

Irfan S, Ehmcke J, Wahab F, Shahab M, Schlatt S

Andrologia12 Jun 2013Cited by 27 (Europe PMC)

PMID23758287 (opens in a new tab)DOI10.1111/and.12121 (opens in a new tab)PepBankPUB-23758287
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In adult male rhesus monkeys, an intravenous bolus of human kisspeptin‑10 caused a single luteinizing hormone pulse.

    In plain wordsIn male monkeys, one injection of kisspeptin‑10 caused a single pulse of luteinizing hormone.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseLuteinizing hormone pulse
    Study

    rhesus monkeyn = 4

    Clamped adult male monkey model
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    50 μg · intravenous bolusAs given in this study (rhesus monkey).

    Source sentences

    Summary
    The peripheral administration of human kisspeptin-10 (50 μg, iv bolus) caused a single LH pulse
    2 context sentences
    Summary · context
    We employed the clamped monkey model to assess the intratesticular actions of kisspeptin.
    Summary · context
    Plasma testosterone and LH levels were monitored in four adult male monkeys.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In adult male rhesus monkeys, an intravenous bolus of human kisspeptin‑10 was followed by a robust increase in plasma testosterone sustained for at least 180 min.

    In plain wordsIn male monkeys, one injection of kisspeptin‑10 was followed by a strong rise in blood testosterone that lasted at least 180 minutes.

    Peptide
    Kisspeptin-10
    Outcome
    IncreasePlasma testosterone
    Study

    rhesus monkeyn = 4

    Clamped adult male monkey model
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    50 μg · intravenous bolusAs given in this study (rhesus monkey).

    Source sentences

    Summary
    The peripheral administration of human kisspeptin-10 (50 μg, iv bolus) caused a single LH pulse, which was followed by a robust increase in plasma testosterone levels sustained for at least 180 min.
    2 context sentences
    Summary · context
    We employed the clamped monkey model to assess the intratesticular actions of kisspeptin.
    Summary · context
    Plasma testosterone and LH levels were monitored in four adult male monkeys.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In adult male rhesus monkeys pretreated with the GnRH receptor antagonist acyline, the testosterone response to kisspeptin‑10 was abolished.

    In plain wordsIn male monkeys given a GnRH blocker first, kisspeptin‑10 no longer raised testosterone.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeTestosterone response to kisspeptin-10 in GnRH receptor antagonist (acyline) pretreated animals
    Study

    rhesus monkeyn = 4

    Clamped adult male monkey model
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    50 μg · intravenous bolusAs given in this study (rhesus monkey).

    Source sentences

    Summary
    This response was abolished when kisspeptin was administered to GnRH receptor antagonist (acyline) pre-treated animals.
    2 context sentences
    Summary · context
    We employed the clamped monkey model to assess the intratesticular actions of kisspeptin.
    Summary · context
    Plasma testosterone and LH levels were monitored in four adult male monkeys.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In acyline pretreated adult male rhesus monkeys, kisspeptin‑10 significantly elevated hCG-stimulated testosterone compared with saline plus hCG.

    In plain wordsIn male monkeys given a GnRH blocker, kisspeptin‑10 raised hCG-stimulated testosterone more than saline did.

    Peptide
    Kisspeptin-10
    Outcome
    IncreasehCG-stimulated testosterone in acyline pretreated monkeys
    Study

    rhesus monkeyn = 4

    Clamped adult male monkey model
    Comparator
    Saline plus hCG
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    50 μg · intravenous bolusAs given in this study (rhesus monkey).

    Source sentences

    Summary
    However, kisspeptin administration significantly (P < 0.005) elevated hCG-stimulated testosterone levels in acyline pre-treated monkeys when compared with saline+ hCG treatment.
    2 context sentences
    Summary · context
    We employed the clamped monkey model to assess the intratesticular actions of kisspeptin.
    Summary · context
    Plasma testosterone and LH levels were monitored in four adult male monkeys.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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