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Study · In vitro (cells) · 2013

8 results

Thymosin beta4 induces angiogenesis through Notch signaling in endothelial cells.

Lv S, Cheng G, Zhou Y, Xu G

Molecular and cellular biochemistry8 Jun 2013Cited by 22 (Europe PMC)

PMID23749167 (opens in a new tab)DOI10.1007/s11010-013-1713-8 (opens in a new tab)PepBankPUB-23749167
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In HUVEC, Tβ4 increased Notch1 expression in a dose and time-dependent manner.

    In plain wordsIn cells, Tβ4 raised Notch1 levels in human vein cells, more with higher dose and longer time.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseNotch1 expression
    Study

    humann: not reported in source

    HUVEC
    Outcome group
    Angiogenesis · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Our results revealed that Tβ4 increased Notch1 and Notch4 expression in a dose and time-dependent manner.
    1 context sentence
    Summary · context
    In this article, we evaluated the effect of Notch signaling in Tβ4-induced angiogenesis in human umbilical vein endothelial cell (HUVEC).
  2. 02LabIn vitro (cells)Mechanism

    In HUVEC, Tβ4 increased Notch4 expression in a dose and time-dependent manner.

    In plain wordsIn cells, Tβ4 raised Notch4 levels in human vein cells, more with higher dose and longer time.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseNotch4 expression
    Study

    humann: not reported in source

    HUVEC
    Outcome group
    Angiogenesis · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Our results revealed that Tβ4 increased Notch1 and Notch4 expression in a dose and time-dependent manner.
    1 context sentence
    Summary · context
    In this article, we evaluated the effect of Notch signaling in Tβ4-induced angiogenesis in human umbilical vein endothelial cell (HUVEC).
  3. 03LabIn vitro (cells)Mechanism

    In HUVEC, inhibition of Notch1 or Notch4 with siRNA or DAPT significantly prevented Tβ4-induced tube formation.

    In plain wordsIn cells, blocking Notch stopped Tβ4 from causing blood-vessel-like tube formation in human vein cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableTβ4-induced HUVEC tube formation with Notch inhibited
    Study

    humann: not reported in source

    HUVEC
    Comparator
    Tβ4 without Notch inhibition
    Outcome group
    Angiogenesis · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The inhibition of Notch1 or Notch4 with siRNA or the Notch receptor inhibitor DAPT significantly prevented Tβ4-induced HUVEC tube formation and lymphocyte transendothelial migration.
    1 context sentence
    Summary · context
    In this article, we evaluated the effect of Notch signaling in Tβ4-induced angiogenesis in human umbilical vein endothelial cell (HUVEC).
  4. 04LabIn vitro (cells)Mechanism

    In HUVEC, inhibition of Notch1 or Notch4 significantly prevented Tβ4-induced lymphocyte transendothelial migration.

    In plain wordsIn cells, blocking Notch stopped Tβ4 from causing lymphocyte movement through human vein cell layers.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableTβ4-induced lymphocyte transendothelial migration with Notch inhibited
    Study

    humann: not reported in source

    HUVEC
    Comparator
    Tβ4 without Notch inhibition
    Outcome group
    Angiogenesis · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The inhibition of Notch1 or Notch4 with siRNA or the Notch receptor inhibitor DAPT significantly prevented Tβ4-induced HUVEC tube formation and lymphocyte transendothelial migration.
    1 context sentence
    Summary · context
    In this article, we evaluated the effect of Notch signaling in Tβ4-induced angiogenesis in human umbilical vein endothelial cell (HUVEC).
  5. 05LabIn vitro (cells)Mechanism

    In HUVEC, inhibition of Notch1 or Notch4 blocked Tβ4-induced VEGF expression.

    In plain wordsIn cells, blocking Notch stopped Tβ4 from raising VEGF in human vein cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableTβ4-induced VEGF expression with Notch inhibited
    Study

    humann: not reported in source

    HUVEC
    Comparator
    Tβ4 without Notch inhibition
    Outcome group
    Angiogenesis · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The inhibition of Notch1 or Notch4 also blocked Tβ4-induced VEGF and HIF-1α expression.
    1 context sentence
    Summary · context
    In this article, we evaluated the effect of Notch signaling in Tβ4-induced angiogenesis in human umbilical vein endothelial cell (HUVEC).
  6. 06LabIn vitro (cells)Mechanism

    In HUVEC, inhibition of Notch1 or Notch4 blocked Tβ4-induced HIF-1α expression.

    In plain wordsIn cells, blocking Notch stopped Tβ4 from raising HIF-1α in human vein cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableTβ4-induced HIF-1α expression with Notch inhibited
    Study

    humann: not reported in source

    HUVEC
    Comparator
    Tβ4 without Notch inhibition
    Outcome group
    Angiogenesis · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The inhibition of Notch1 or Notch4 also blocked Tβ4-induced VEGF and HIF-1α expression.
    1 context sentence
    Summary · context
    In this article, we evaluated the effect of Notch signaling in Tβ4-induced angiogenesis in human umbilical vein endothelial cell (HUVEC).
  7. 07LabIn vitro (cells)Mechanism

    In HUVEC, Tβ4 significantly reduced VE-cadherin expression.

    In plain wordsIn cells, Tβ4 lowered VE-cadherin, a cell-adhesion protein, in human vein cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseVE-cadherin expression
    Study

    humann: not reported in source

    HUVEC
    Outcome group
    Angiogenesis · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Tβ4 significantly reduced VE-cadherin expression levels in HUVEC, while the inhibition of Notch signaling prevented Tβ4-induced VE-cadherin down-regulation.
    1 context sentence
    Summary · context
    In this article, we evaluated the effect of Notch signaling in Tβ4-induced angiogenesis in human umbilical vein endothelial cell (HUVEC).
  8. 08LabIn vitro (cells)Mechanism

    In HUVEC, inhibition of Notch signaling prevented Tβ4-induced VE-cadherin down-regulation.

    In plain wordsIn cells, blocking Notch stopped Tβ4 from lowering VE-cadherin in human vein cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableTβ4-induced VE-cadherin down-regulation with Notch inhibited
    Study

    humann: not reported in source

    HUVEC
    Comparator
    Tβ4 without Notch inhibition
    Outcome group
    Angiogenesis · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    while the inhibition of Notch signaling prevented Tβ4-induced VE-cadherin down-regulation.
    1 context sentence
    Summary · context
    In this article, we evaluated the effect of Notch signaling in Tβ4-induced angiogenesis in human umbilical vein endothelial cell (HUVEC).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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