In growth cones and neuroblastoma cells, endogenous thymosin β4 and profilin were identified as key molecules that localize actin monomers to the leading edge of lamellipodia.
In plain wordsIn cells, the body's own thymosin β4 helps move actin building blocks to the front edge of moving cells.
- Peptide
- Thymosin beta-4 (human)
- Outcome
- Not applicableLocalization of actin monomers to the leading edge by thymosin β4
- Study
n: not reported in source
Growth cones and neuroblastoma cells- Outcome group
- Receptor activity and mechanism · Nervous system and cognition
Source sentences
Finally, we identify the actin monomer-binding proteins profilin and thymosin β4 as key molecules that localize actin monomers to the leading edge of lamellipodia for their motility.
1 context sentence(design, population, supporting numbers)
Here we report that a pool of G-actin dynamically localizes to the leading edge of growth cones and neuroblastoma cells to spatially elevate the G-/F-actin ratio that drives membrane protrusion and cell movement.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.