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Study · Animal study (in vivo) · mouse · 2013

5 results

Thymosin β4 and its degradation product, Ac-SDKP, are novel reparative factors in renal fibrosis.

Zuo Y, Chun B, Potthoff SA, Kazi N, Brolin TJ, Orhan D, Yang HC, Ma LJ, Kon V, Myöhänen T, Rhaleb NE, Carretero OA, Fogo AB

Kidney international5 Jun 2013Cited by 74 (Europe PMC)

PMID23739235 (opens in a new tab)PMCIDPMC3830708 (opens in a new tab)DOI10.1038/ki.2013.209 (opens in a new tab)PepBankPUB-23739235
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In wild-type mice with unilateral ureteral obstruction, Tβ4 alone promoted renal repair.

    In plain wordsIn mice with kidney injury, Tβ4 alone promoted repair of the kidney.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseRenal repair (Tβ4 alone, wild-type mice)
    Study

    mousen: not reported in source

    Unilateral ureteral obstruction renal fibrosis
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Tβ4 alone also promoted repair and reduced late fibrosis in wild-type mice.
    1 context sentence
    Summary · context
    Here we studied renal fibrosis in wild-type and PAI-1 knockout mice following unilateral ureteral obstruction to explore the impact of Tβ4 and its prolyl oligopeptidase tetrapeptide degradation product, N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP), in renal fibrosis.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In wild-type mice with unilateral ureteral obstruction, Tβ4 alone reduced late fibrosis.

    In plain wordsIn mice with kidney injury, Tβ4 alone reduced late-stage scarring of the kidney.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseLate fibrosis (Tβ4 alone, wild-type mice)
    Study

    mousen: not reported in source

    Unilateral ureteral obstruction renal fibrosis
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Tβ4 alone also promoted repair and reduced late fibrosis in wild-type mice.
    1 context sentence
    Summary · context
    Here we studied renal fibrosis in wild-type and PAI-1 knockout mice following unilateral ureteral obstruction to explore the impact of Tβ4 and its prolyl oligopeptidase tetrapeptide degradation product, N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP), in renal fibrosis.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In PAI-1 knockout mice, the late reparative effects of Tβ4 alone were absent.

    In plain wordsIn mice lacking PAI-1, the late repair effect of Tβ4 alone did not appear.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    No significant changeLate reparative effect of Tβ4 alone (PAI-1 knockout mice)
    Study

    mousen: not reported in source

    Unilateral ureteral obstruction in PAI-1 knockout mice
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Importantly, both profibrotic effects of Tβ4 plus the prolyl oligopeptidase inhibitor, and late reparative effects of Tβ4 alone, were absent in PAI-1 knockout mice.
    1 context sentence
    Summary · context
    Here we studied renal fibrosis in wild-type and PAI-1 knockout mice following unilateral ureteral obstruction to explore the impact of Tβ4 and its prolyl oligopeptidase tetrapeptide degradation product, N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP), in renal fibrosis.

Studies that did not test the peptide alone2

In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin beta-4 (human).

  1. 04AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Efficacy outcome

    In wild-type mice with unilateral ureteral obstruction, Tβ4 plus a prolyl oligopeptidase inhibitor significantly increased fibrosis.

    In plain wordsIn mice with kidney injury, Tβ4 given with a prolyl oligopeptidase inhibitor increased kidney scarring.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseFibrosis with Tβ4 plus prolyl oligopeptidase inhibitor (wild-type mice)
    Study

    mousen: not reported in source

    Unilateral ureteral obstruction renal fibrosis
    Outcome group
    Kidney function · Kidney and urinary

    Source sentences

    Summary
    In contrast, Tβ4 plus a prolyl oligopeptidase inhibitor significantly increased fibrosis in wild-type mice.
    1 context sentence
    Summary · context
    Here we studied renal fibrosis in wild-type and PAI-1 knockout mice following unilateral ureteral obstruction to explore the impact of Tβ4 and its prolyl oligopeptidase tetrapeptide degradation product, N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP), in renal fibrosis.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  2. 05AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Efficacy outcome

    In PAI-1 knockout mice, the profibrotic effect of Tβ4 plus a prolyl oligopeptidase inhibitor was absent.

    In plain wordsIn mice lacking PAI-1, the scarring effect of Tβ4 given with an inhibitor did not appear.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    No significant changeProfibrotic effect of Tβ4 plus prolyl oligopeptidase inhibitor (PAI-1 knockout mice)
    Study

    mousen: not reported in source

    Unilateral ureteral obstruction in PAI-1 knockout mice
    Outcome group
    Kidney function · Kidney and urinary

    Source sentences

    Summary
    Importantly, both profibrotic effects of Tβ4 plus the prolyl oligopeptidase inhibitor, and late reparative effects of Tβ4 alone, were absent in PAI-1 knockout mice.
    1 context sentence
    Summary · context
    Here we studied renal fibrosis in wild-type and PAI-1 knockout mice following unilateral ureteral obstruction to explore the impact of Tβ4 and its prolyl oligopeptidase tetrapeptide degradation product, N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP), in renal fibrosis.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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