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Study · Randomized controlled trial · n = 23 · 2013

2 results

Effects of single dose intranasal oxytocin on social cognition in schizophrenia.

Davis MC, Lee J, Horan WP, Clarke AD, McGee MR, Green MF, Marder SR

Schizophrenia research12 May 2013Cited by 95 (Europe PMC)

PMID23676253 (opens in a new tab)DOI10.1016/j.schres.2013.04.023 (opens in a new tab)PepBankPUB-23676253
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In male veterans with schizophrenia, a single dose of oxytocin did not significantly change the social cognition composite score versus placebo.

    In plain wordsIn male veterans with schizophrenia, one dose of oxytocin did not change overall social cognition more than placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeSocial cognition composite score
    Study

    n = 23

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Mental health and mood
    Studied dose
    40 IU · intranasal · single doseAs given in this study (human).

    Source sentences

    Summary
    Though the groups did not differ significantly on the social cognition composite score
    2 context sentences
    Summary · context
    Twenty-three male veterans with schizophrenia completed baseline assessments of social cognition that were divided into lower-level (facial affect perception, social perception, detection of lies) and higher-level (detection of sarcasm and deception, empathy) processes.
    Summary · context
    One week later, patients received the same battery after being randomized to a single dose of 40 IU intranasal oxytocin or placebo.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In male veterans with schizophrenia, a single dose of oxytocin improved performance on higher-level social cognitive tasks versus placebo.

    In plain wordsIn male veterans with schizophrenia, one dose of oxytocin improved higher-level social thinking tasks more than placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseHigher-level social cognitive tasks
    Study

    n = 23

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Mental health and mood
    Studied dose
    40 IU · intranasal · single doseAs given in this study (human).

    Measurements

    Cohen's d
    1
    higher-level social cognitive tasks

    Source sentences

    Summary
    oxytocin improved performance for the higher-level social cognitive tasks (Cohen's d=1.0, p=0.045).
    2 context sentences
    Summary · context
    Twenty-three male veterans with schizophrenia completed baseline assessments of social cognition that were divided into lower-level (facial affect perception, social perception, detection of lies) and higher-level (detection of sarcasm and deception, empathy) processes.
    Summary · context
    One week later, patients received the same battery after being randomized to a single dose of 40 IU intranasal oxytocin or placebo.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials1

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

1 trial · 1 completed · 1 with posted results · source ClinicalTrials.gov (opens in a new tab)

CompletedNot applicableResults postedNCT01312272

Does Acute Oxytocin Administration Enhance Social Cognition in Individuals With Schizophrenia?

VA Greater Los Angeles Healthcare Systemn = 24Apr 2011 to Aug 2012

Schizophrenia

Trial pageClinicalTrials.govUpdated 2 May 2014

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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