Skip to content

Study · Animal study (in vivo) · mouse · 2013

11 results

[Gly14]-Humanin offers neuroprotection through glycogen synthase kinase-3β inhibition in a mouse model of intracerebral hemorrhage.

Wang T, Huang Y, Zhang M, Wang L, Wang Y, Zhang L, Dong W, Chang P, Wang Z, Chen X, Tao L

Behavioural brain research26 Mar 2013Cited by 33 (Europe PMC)

PMID23538063 (opens in a new tab)DOI10.1016/j.bbr.2013.03.023 (opens in a new tab)PepBankPUB-23538063
Publisher pagePubMedAsk about this study
Jump to 11 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

11 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with intracerebral hemorrhage, HNG 2.5 μg improved neurological outcome at 24 and 72 h versus vehicle.

    In plain wordsIn mice with brain bleeding, a humanin analog improved nerve function compared with vehicle.

    Peptide
    Humanin
    Outcome
    IncreaseNeurological outcome
    Study

    mousen: not reported in source

    Collagenase-induced intracerebral hemorrhage
    Comparator
    Vehicle
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    2.5 μg in 100 μl saline · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Compared with vehicle, HNG-2.5 μg treatment improved neurological outcome and reduced brain edema at 24 and 72 h after surgery (P<0.05)
    2 context sentences
    Summary · context
    Male ICR mice were subjected to infusion of Type IV collagenase (to induce ICH) of saline (for shams) into the left striatum.
    Summary · context
    ICH animals received vehicle, HNG (1 or 2.5 μg in 100 μl saline) administration intraperitoneally 1h post injury.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with intracerebral hemorrhage, HNG 2.5 μg reduced brain edema at 24 and 72 h versus vehicle.

    In plain wordsIn mice with brain bleeding, a humanin analog reduced brain swelling compared with vehicle.

    Peptide
    Humanin
    Outcome
    DecreaseBrain edema
    Study

    mousen: not reported in source

    Collagenase-induced intracerebral hemorrhage
    Comparator
    Vehicle
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    2.5 μg in 100 μl saline · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Compared with vehicle, HNG-2.5 μg treatment improved neurological outcome and reduced brain edema at 24 and 72 h after surgery (P<0.05)
    2 context sentences
    Summary · context
    Male ICR mice were subjected to infusion of Type IV collagenase (to induce ICH) of saline (for shams) into the left striatum.
    Summary · context
    ICH animals received vehicle, HNG (1 or 2.5 μg in 100 μl saline) administration intraperitoneally 1h post injury.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In mice with intracerebral hemorrhage, wortmannin pretreatment obliterated the improvement in neurological outcome and brain edema produced by HNG 2.5 μg.

    In plain wordsIn mice with brain bleeding, the PI3K blocker wortmannin removed the benefit that a humanin analog showed on nerve function and swelling.

    Peptide
    Humanin
    Outcome
    No significant changeWortmannin block of neurological and edema effects
    Study

    mousen: not reported in source

    Collagenase-induced intracerebral hemorrhage
    Comparator
    HNG-2.5 μg after wortmannin pretreatment
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    2.5 μg in 100 μl saline · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    but wortmannin (15 μg/kg, 90 min before HNG-2.5 μg, intravenously) obliterated the effect.
    2 context sentences
    Summary · context
    Male ICR mice were subjected to infusion of Type IV collagenase (to induce ICH) of saline (for shams) into the left striatum.
    Summary · context
    ICH animals received vehicle, HNG (1 or 2.5 μg in 100 μl saline) administration intraperitoneally 1h post injury.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In mice with intracerebral hemorrhage, HNG 2.5 μg reduced cell insults at 24 and 72 h versus vehicle.

    In plain wordsIn mice with brain bleeding, a humanin analog reduced cell damage compared with vehicle.

    Peptide
    Humanin
    Outcome
    DecreaseCell insults
    Study

    mousen: not reported in source

    Collagenase-induced intracerebral hemorrhage
    Comparator
    Vehicle
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    2.5 μg in 100 μl saline · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    HNG-2.5 μg also reduced cell insults and injury volume at 24 and 72 h after surgery (P<0.05, vs. vehicle).
    2 context sentences
    Summary · context
    Male ICR mice were subjected to infusion of Type IV collagenase (to induce ICH) of saline (for shams) into the left striatum.
    Summary · context
    ICH animals received vehicle, HNG (1 or 2.5 μg in 100 μl saline) administration intraperitoneally 1h post injury.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In mice with intracerebral hemorrhage, HNG 2.5 μg reduced injury volume at 24 and 72 h versus vehicle.

    In plain wordsIn mice with brain bleeding, a humanin analog reduced the size of brain injury compared with vehicle.

    Peptide
    Humanin
    Outcome
    DecreaseInjury volume
    Study

    mousen: not reported in source

    Collagenase-induced intracerebral hemorrhage
    Comparator
    Vehicle
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    2.5 μg in 100 μl saline · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    HNG-2.5 μg also reduced cell insults and injury volume at 24 and 72 h after surgery (P<0.05, vs. vehicle).
    2 context sentences
    Summary · context
    Male ICR mice were subjected to infusion of Type IV collagenase (to induce ICH) of saline (for shams) into the left striatum.
    Summary · context
    ICH animals received vehicle, HNG (1 or 2.5 μg in 100 μl saline) administration intraperitoneally 1h post injury.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In mice with intracerebral hemorrhage, HNG 2.5 μg increased p-Akt expression in the ipsilateral hemisphere versus vehicle.

    In plain wordsIn mice with brain bleeding, a humanin analog raised p-Akt in the injured brain side compared with vehicle.

    Peptide
    Humanin
    Outcome
    Increasep-Akt expression in ipsilateral hemisphere
    Study

    mousen: not reported in source

    Collagenase-induced intracerebral hemorrhage
    Comparator
    Vehicle
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    2.5 μg in 100 μl saline · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Furthermore, HNG-2.5 μg treatment increased p-Akt and Bcl-2 and decreased p-GSK-3β, cleaved caspase-3 and cleaved poly (ADP-ribose) polymerase expressions in the ipsilateral hemisphere (P<0.05, vs. vehicle)
    2 context sentences
    Summary · context
    Male ICR mice were subjected to infusion of Type IV collagenase (to induce ICH) of saline (for shams) into the left striatum.
    Summary · context
    ICH animals received vehicle, HNG (1 or 2.5 μg in 100 μl saline) administration intraperitoneally 1h post injury.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In mice with intracerebral hemorrhage, HNG 2.5 μg increased Bcl-2 expression in the ipsilateral hemisphere versus vehicle.

    In plain wordsIn mice with brain bleeding, a humanin analog raised Bcl-2 in the injured brain side compared with vehicle.

    Peptide
    Humanin
    Outcome
    IncreaseBcl-2 expression in ipsilateral hemisphere
    Study

    mousen: not reported in source

    Collagenase-induced intracerebral hemorrhage
    Comparator
    Vehicle
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    2.5 μg in 100 μl saline · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Furthermore, HNG-2.5 μg treatment increased p-Akt and Bcl-2 and decreased p-GSK-3β, cleaved caspase-3 and cleaved poly (ADP-ribose) polymerase expressions in the ipsilateral hemisphere (P<0.05, vs. vehicle)
    2 context sentences
    Summary · context
    Male ICR mice were subjected to infusion of Type IV collagenase (to induce ICH) of saline (for shams) into the left striatum.
    Summary · context
    ICH animals received vehicle, HNG (1 or 2.5 μg in 100 μl saline) administration intraperitoneally 1h post injury.
  8. 08AnimalAnimal study (in vivo)Mechanism

    In mice with intracerebral hemorrhage, HNG 2.5 μg decreased p-GSK-3β expression in the ipsilateral hemisphere versus vehicle.

    In plain wordsIn mice with brain bleeding, a humanin analog lowered p-GSK-3β in the injured brain side compared with vehicle.

    Peptide
    Humanin
    Outcome
    Decreasep-GSK-3β expression in ipsilateral hemisphere
    Study

    mousen: not reported in source

    Collagenase-induced intracerebral hemorrhage
    Comparator
    Vehicle
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    2.5 μg in 100 μl saline · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Furthermore, HNG-2.5 μg treatment increased p-Akt and Bcl-2 and decreased p-GSK-3β, cleaved caspase-3 and cleaved poly (ADP-ribose) polymerase expressions in the ipsilateral hemisphere (P<0.05, vs. vehicle)
    2 context sentences
    Summary · context
    Male ICR mice were subjected to infusion of Type IV collagenase (to induce ICH) of saline (for shams) into the left striatum.
    Summary · context
    ICH animals received vehicle, HNG (1 or 2.5 μg in 100 μl saline) administration intraperitoneally 1h post injury.
  9. 09AnimalAnimal study (in vivo)Mechanism

    In mice with intracerebral hemorrhage, HNG 2.5 μg decreased cleaved caspase-3 expression in the ipsilateral hemisphere versus vehicle.

    In plain wordsIn mice with brain bleeding, a humanin analog lowered cleaved caspase-3 in the injured brain side compared with vehicle.

    Peptide
    Humanin
    Outcome
    DecreaseCleaved caspase-3 expression in ipsilateral hemisphere
    Study

    mousen: not reported in source

    Collagenase-induced intracerebral hemorrhage
    Comparator
    Vehicle
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    2.5 μg in 100 μl saline · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Furthermore, HNG-2.5 μg treatment increased p-Akt and Bcl-2 and decreased p-GSK-3β, cleaved caspase-3 and cleaved poly (ADP-ribose) polymerase expressions in the ipsilateral hemisphere (P<0.05, vs. vehicle)
    2 context sentences
    Summary · context
    Male ICR mice were subjected to infusion of Type IV collagenase (to induce ICH) of saline (for shams) into the left striatum.
    Summary · context
    ICH animals received vehicle, HNG (1 or 2.5 μg in 100 μl saline) administration intraperitoneally 1h post injury.
  10. 10AnimalAnimal study (in vivo)Mechanism

    In mice with intracerebral hemorrhage, HNG 2.5 μg decreased cleaved poly (ADP-ribose) polymerase expression in the ipsilateral hemisphere versus vehicle.

    In plain wordsIn mice with brain bleeding, a humanin analog lowered cleaved PARP in the injured brain side compared with vehicle.

    Peptide
    Humanin
    Outcome
    DecreaseCleaved PARP expression in ipsilateral hemisphere
    Study

    mousen: not reported in source

    Collagenase-induced intracerebral hemorrhage
    Comparator
    Vehicle
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    2.5 μg in 100 μl saline · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Furthermore, HNG-2.5 μg treatment increased p-Akt and Bcl-2 and decreased p-GSK-3β, cleaved caspase-3 and cleaved poly (ADP-ribose) polymerase expressions in the ipsilateral hemisphere (P<0.05, vs. vehicle)
    2 context sentences
    Summary · context
    Male ICR mice were subjected to infusion of Type IV collagenase (to induce ICH) of saline (for shams) into the left striatum.
    Summary · context
    ICH animals received vehicle, HNG (1 or 2.5 μg in 100 μl saline) administration intraperitoneally 1h post injury.
  11. 11AnimalAnimal study (in vivo)Mechanism

    In mice with intracerebral hemorrhage, wortmannin reversed the effects of HNG 2.5 μg on p-Akt, Bcl-2, p-GSK-3β, cleaved caspase-3 and cleaved PARP expression.

    In plain wordsIn mice with brain bleeding, the PI3K blocker wortmannin reversed the changes that a humanin analog caused in cell-death signals.

    Peptide
    Humanin
    Outcome
    No significant changeWortmannin reversal of molecular effects
    Study

    mousen: not reported in source

    Collagenase-induced intracerebral hemorrhage
    Comparator
    HNG-2.5 μg after wortmannin pretreatment
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    2.5 μg in 100 μl saline · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    however, the effect was reversed by wortmannin.
    2 context sentences
    Summary · context
    Male ICR mice were subjected to infusion of Type IV collagenase (to induce ICH) of saline (for shams) into the left striatum.
    Summary · context
    ICH animals received vehicle, HNG (1 or 2.5 μg in 100 μl saline) administration intraperitoneally 1h post injury.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.