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Study · In vitro (cells) · 2013

5 results

KISS1R induces invasiveness of estrogen receptor-negative human mammary epithelial and breast cancer cells.

Cvetkovic D, Dragan M, Leith SJ, Mir ZM, Leong HS, Pampillo M, Lewis JD, Babwah AV, Bhattacharya M

Endocrinology24 Mar 2013Cited by 38 (Europe PMC)

PMID23525242 (opens in a new tab)DOI10.1210/en.2012-2164 (opens in a new tab)PepBankPUB-23525242
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In ERα-negative MCF10A mammary epithelial cells, KP-10 treatment induced a mesenchymal phenotype.

    In plain wordsIn lab tests on breast-type cells, KP-10 made the cells take on a more mobile, invasive form.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseMesenchymal phenotype in MCF10A cells
    Study

    humann: not reported in source

    MCF10A nonmalignant mammary epithelial cells
    Outcome group
    Cancer cell invasion and metastasis · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Here, we report that either KP-10 treatment of ERα-negative nonmalignant mammary epithelial MCF10A cells or expression of KISS1R in MCF10A cells induced a mesenchymal phenotype and stimulated invasiveness.
  2. 02LabIn vitro (cells)Efficacy outcome

    In ERα-negative MCF10A mammary epithelial cells, KP-10 treatment stimulated invasiveness.

    In plain wordsIn lab tests on breast-type cells, KP-10 made the cells more invasive.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseInvasiveness of MCF10A cells
    Study

    humann: not reported in source

    MCF10A nonmalignant mammary epithelial cells
    Outcome group
    Cancer cell invasion and metastasis · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Here, we report that either KP-10 treatment of ERα-negative nonmalignant mammary epithelial MCF10A cells or expression of KISS1R in MCF10A cells induced a mesenchymal phenotype and stimulated invasiveness.
  3. 03LabIn vitro (cells)Mechanism

    In ERα-positive MCF7 and T47D breast cancer cells, KP-10 did not transactivate EGFR.

    In plain wordsIn lab tests on breast cancer cells, KP-10 did not activate the EGF receptor.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeEGFR transactivation in ERα-positive breast cancer cells
    Study

    humann: not reported in source

    MCF7 and T47D breast cancer cells
    Outcome group
    Cancer cell invasion and metastasis · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In contrast, KP-10 failed to transactivate EGFR or stimulate invasiveness in the ERα-positive MCF7 and T47D breast cancer cells.
  4. 04LabIn vitro (cells)Efficacy outcome

    In ERα-positive MCF7 and T47D breast cancer cells, KP-10 did not stimulate invasiveness.

    In plain wordsIn lab tests on breast cancer cells, KP-10 did not make the cells more invasive.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeInvasiveness of ERα-positive breast cancer cells
    Study

    humann: not reported in source

    MCF7 and T47D breast cancer cells
    Outcome group
    Cancer cell invasion and metastasis · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In contrast, KP-10 failed to transactivate EGFR or stimulate invasiveness in the ERα-positive MCF7 and T47D breast cancer cells.

Studies that did not test the peptide alone1

In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Kisspeptin-10.

  1. 05LabNot a test of Kisspeptin-10 aloneIn vitro (cells)Mechanism

    In MDA-MB-231 cells, exogenous ERα expression ablated KP-10-induced effects by down-regulating KISS1R expression.

    In plain wordsIn lab tests on breast cancer cells, adding estrogen receptor alpha removed the effects of KP-10.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseERα expression blocking KP-10-induced effects
    Study

    humann: not reported in source

    MDA-MB-231 breast cancer cells
    Outcome group
    Cancer cell invasion and metastasis · Cancer

    Source sentences

    Summary
    In support of this, we found that these KP-10-induced effects were ablated upon exogenous expression of ERα in the MDA-MB-231 cells, by down-regulating KISS1R expression.

    In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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