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Study · Animal study (in vivo) · rat · 2013

4 results

Thymosin β4 enhances the healing of medial collateral ligament injury in rat.

Xu B, Yang M, Li Z, Zhang Y, Jiang Z, Guan S, Jiang D

Regulatory peptides21 Mar 2013Cited by 6 (Europe PMC)

PMID23523891 (opens in a new tab)DOI10.1016/j.regpep.2013.03.026 (opens in a new tab)PepBankPUB-23523891
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with transected medial collateral ligaments, healing tissue in Tβ4-treated animals showed uniform, evenly spaced fiber bundles, unlike controls.

    In plain wordsIn rats with a cut knee ligament, Tβ4 treatment gave more evenly arranged collagen fibers than in control rats.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseHistology of healing tissue (fiber bundle organisation)
    Study

    ratn: not reported in source

    Medial collateral ligament transection
    Comparator
    Control
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    1 μg in 100 μL fibrin sealant · local, placed in the ligament gap in fibrin sealantAs given in this study (rat).

    Source sentences

    Summary
    Histologically, healing tissues in Tβ4-treated group exhibited uniform and evenly spaced fiber bundles. However, the collagen fibers were not evenly spaced in control rats.
    3 context sentences
    Summary · context
    The medial collateral ligament (MCL) was sharply transected on the day of surgery.
    Summary · context
    Then, the treatment group received 100 μL of fibrin sealant containing 1 μg of Tβ4 placed in the ligament gap.
    Summary · context
    Healing tissues were evaluated by hematoxylin and eosin stain, transmission electron microscopy, and biomechanical test at 4 weeks after surgery.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with transected medial collateral ligaments, Tβ4 treatment significantly increased collagen fibril diameters in granulation tissue.

    In plain wordsIn rats with a cut knee ligament, Tβ4 treatment made collagen fibrils thicker.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseCollagen fibril diameter in granulation tissue
    Study

    ratn: not reported in source

    Medial collateral ligament transection
    Comparator
    Control
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    1 μg in 100 μL fibrin sealant · local, placed in the ligament gap in fibrin sealantAs given in this study (rat).

    Source sentences

    Summary
    Moreover, diameters of collagen fibrils within granulation tissue from the Tβ4-treated rats were significantly increased.
    3 context sentences
    Summary · context
    The medial collateral ligament (MCL) was sharply transected on the day of surgery.
    Summary · context
    Then, the treatment group received 100 μL of fibrin sealant containing 1 μg of Tβ4 placed in the ligament gap.
    Summary · context
    Healing tissues were evaluated by hematoxylin and eosin stain, transmission electron microscopy, and biomechanical test at 4 weeks after surgery.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with transected medial collateral ligaments, mechanical properties of healing tissue were significantly higher with Tβ4 at 4 weeks.

    In plain wordsIn rats with a cut knee ligament, healing tissue was mechanically stronger after Tβ4 treatment at 4 weeks.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseMechanical properties of healing tissue at 4 weeks
    Study

    ratn: not reported in source

    Medial collateral ligament transection
    Comparator
    Control
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    1 μg in 100 μL fibrin sealant · local, placed in the ligament gap in fibrin sealantAs given in this study (rat).

    Source sentences

    Summary
    In Tβ4-treated MCLs, the mechanical properties of these healing tissues were significantly higher at 4 weeks after surgery.
    3 context sentences
    Summary · context
    The medial collateral ligament (MCL) was sharply transected on the day of surgery.
    Summary · context
    Then, the treatment group received 100 μL of fibrin sealant containing 1 μg of Tβ4 placed in the ligament gap.
    Summary · context
    Healing tissues were evaluated by hematoxylin and eosin stain, transmission electron microscopy, and biomechanical test at 4 weeks after surgery.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats with transected medial collateral ligaments, Tβ4-treated femur-MCL-tibia complexes had significantly better biomechanical properties than controls at 4 weeks.

    In plain wordsIn rats with a cut knee ligament, the healed knee joint structure performed better after Tβ4 than in controls at 4 weeks.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseBiomechanical properties of femur-MCL-tibia complexes at 4 weeks
    Study

    ratn: not reported in source

    Medial collateral ligament transection
    Comparator
    Control
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    1 μg in 100 μL fibrin sealant · local, placed in the ligament gap in fibrin sealantAs given in this study (rat).

    Source sentences

    Summary
    In terms of the mechanical properties of the healing femur-medial collateral ligament-tibia complexes, the Tβ4-treated group had significantly better biomechanical properties than the control group at 4 weeks after surgery.
    3 context sentences
    Summary · context
    The medial collateral ligament (MCL) was sharply transected on the day of surgery.
    Summary · context
    Then, the treatment group received 100 μL of fibrin sealant containing 1 μg of Tβ4 placed in the ligament gap.
    Summary · context
    Healing tissues were evaluated by hematoxylin and eosin stain, transmission electron microscopy, and biomechanical test at 4 weeks after surgery.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

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