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Study · Animal study (in vivo) · mouse · 2013

3 results

Mitochondria-targeted antioxidant promotes recovery of skeletal muscle mitochondrial function after burn trauma assessed by in vivo 31P nuclear magnetic resonance and electron paramagnetic resonance spectroscopy.

Righi V, Constantinou C, Mintzopoulos D, Khan N, Mupparaju SP, Rahme LG, Swartz HM, Szeto HH, Tompkins RG, Tzika AA

FASEB journal : official publication of the Federation of American Societies for Experimental Biology12 Mar 2013Cited by 26 (Europe PMC)

PMID23482635 (opens in a new tab)PMCIDPMC3659352 (opens in a new tab)DOI10.1096/fj.12-220764 (opens in a new tab)PepBankPUB-23482635
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In burned mice, a single dose of SS‑31 increased skeletal muscle oxidative ATP synthesis rate 5-fold at 6 h postburn versus untreated burned mice.

    In plain wordsIn burned mice, one dose of SS‑31 raised muscle energy production five-fold compared with untreated burned mice.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseOxidative ATP synthesis rate at 6 h postburn
    Study

    mousen: not reported in source

    Mouse burn injury model
    Comparator
    Untreated burned mice
    Outcome group
    Mitochondrial function · Musculoskeletal
    Studied dose
    Dose not stated · single doseAs given in this study (mouse).

    Measurements

    ATP synthesis rate fold increase
    5-fold
    SS-31 burned vs untreated burned, 6 h postburn

    Source sentences

    Summary
    At 6 h postburn, the oxidative ATP synthesis rate was increased 5-fold in burned mice given a single dose of SS-31 relative to untreated burned mice (P=0.002).
    1 context sentence
    Summary · context
    We investigated the effects of the mitochondria-targeted peptide antioxidant Szeto-Schiller 31 (SS-31) on skeletal muscle in a mouse burn model
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In burned mice, SS‑31 decreased skeletal muscle mitochondrial aconitase activity back to control levels.

    In plain wordsIn burned mice, SS‑31 brought muscle mitochondrial aconitase activity back down to control levels.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseMitochondrial aconitase activity
    Study

    mousen: not reported in source

    Mouse burn injury model
    Comparator
    Untreated burned mice
    Outcome group
    Mitochondrial function · Musculoskeletal
    Studied dose
    Dose not stated · single doseAs given in this study (mouse).

    Source sentences

    Summary
    Furthermore, SS-31 administration in burned animals decreased mitochondrial aconitase activity back to control levels.
    1 context sentence
    Summary · context
    We investigated the effects of the mitochondria-targeted peptide antioxidant Szeto-Schiller 31 (SS-31) on skeletal muscle in a mouse burn model
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In burned mice, SS‑31 treatment recovered skeletal muscle redox status compared with the untreated burn group.

    In plain wordsIn burned mice, SS‑31 helped muscle redox status recover compared with untreated burned mice.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseSkeletal muscle redox status by EPR
    Study

    mousen: not reported in source

    Mouse burn injury model
    Comparator
    Untreated burned mice
    Outcome group
    Mitochondrial function · Musculoskeletal
    Studied dose
    Dose not stated · single doseAs given in this study (mouse).

    Source sentences

    Summary
    EPR revealed a recovery in redox status of the SS-31-treated burn group compared to the untreated burn group (P<0.05).
    1 context sentence
    Summary · context
    We investigated the effects of the mitochondria-targeted peptide antioxidant Szeto-Schiller 31 (SS-31) on skeletal muscle in a mouse burn model

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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