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Study · Randomized controlled trial · 2013

2 results

Exenatide-induced reduction in energy intake is associated with increase in hypothalamic connectivity.

Schlögl H, Kabisch S, Horstmann A, Lohmann G, Müller K, Lepsien J, Busse-Voigt F, Kratzsch J, Pleger B, Villringer A, Stumvoll M

Diabetes care5 Mar 2013Cited by 67 (Europe PMC)

PMID23462665 (opens in a new tab)PMCIDPMC3687323 (opens in a new tab)DOI10.2337/dc12-1925 (opens in a new tab)PepBankPUB-23462665
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanRandomized controlled trialMechanism

    In obese male responders, exenatide increased hypothalamic connectedness during food pictures compared with placebo.

    In plain wordsIn obese male responders, exenatide increased functional connectedness of hypothalamic activity during food pictures compared with placebo.

    Peptide
    Exenatide (exendin-4)
    Outcome
    IncreaseHypothalamic connectedness in responders
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · intravenousAs given in this study (human).

    Source sentences

    Summary
    Responders showed significantly higher connectedness of the hypothalamus, which was specific for the food pictures condition, in the exenatide condition compared with placebo.
    1 context sentence
    Summary · context
    We performed a randomized, double-blinded, placebo-controlled, cross-over fMRI study with intravenous administration of exenatide in obese male volunteers.
  2. 02HumanRandomized controlled trialMechanism

    In obese male nonresponders, exenatide did not significantly change hypothalamic connectedness compared with placebo.

    In plain wordsIn obese male nonresponders, exenatide did not significantly change functional connectedness of hypothalamic activity compared with placebo.

    Peptide
    Exenatide (exendin-4)
    Outcome
    No significant changeHypothalamic connectedness in nonresponders
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · intravenousAs given in this study (human).

    Source sentences

    Summary
    Nonresponders did not show any significant exenatide-induced changes in hypothalamic connectedness.
    1 context sentence
    Summary · context
    We performed a randomized, double-blinded, placebo-controlled, cross-over fMRI study with intravenous administration of exenatide in obese male volunteers.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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