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Study · Animal study (in vivo) · rat · 2013

8 results

L-carnosine inhibits neuronal cell apoptosis through signal transducer and activator of transcription 3 signaling pathway after acute focal cerebral ischemia.

Wang JP, Yang ZT, Liu C, He YH, Zhao SS

Brain research27 Feb 2013Cited by 31 (Europe PMC)

PMID23454231 (opens in a new tab)DOI10.1016/j.brainres.2013.02.032 (opens in a new tab)PepBankPUB-23454231
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with cerebral ischemia, L‑carnosine reduced neurological deficits versus vehicle at 72 h.

    In plain wordsIn rats with cerebral ischemia, L‑carnosine reduced neurological deficits versus vehicle.

    Peptide
    L-carnosine
    Outcome
    DecreaseNeurological deficits
    Study

    ratn: not reported in source

    Permanent middle cerebral artery occlusion
    Comparator
    Vehicle
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Our results showed that the L-carnosine-treated rats had milder neurological deficits and smaller infarct volume and showed up-regulated expression in mRNA levels of STAT3 and Pim-1 than vehicle-treated rats at 72 h after treatment.
    1 context sentence
    Summary · context
    To investigate the molecular mechanisms, rat models of permanent middle cerebral artery occlusion (pMCAO) and sham operation were first established and then pMCAO and sham-operated rats were treated with L-carnosine or vehicle alone.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with cerebral ischemia, L‑carnosine reduced infarct volume versus vehicle at 72 h.

    In plain wordsIn rats with cerebral ischemia, L‑carnosine reduced infarct volume versus vehicle.

    Peptide
    L-carnosine
    Outcome
    DecreaseInfarct volume
    Study

    ratn: not reported in source

    Permanent middle cerebral artery occlusion
    Comparator
    Vehicle
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Our results showed that the L-carnosine-treated rats had milder neurological deficits and smaller infarct volume and showed up-regulated expression in mRNA levels of STAT3 and Pim-1 than vehicle-treated rats at 72 h after treatment.
    1 context sentence
    Summary · context
    To investigate the molecular mechanisms, rat models of permanent middle cerebral artery occlusion (pMCAO) and sham operation were first established and then pMCAO and sham-operated rats were treated with L-carnosine or vehicle alone.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats with cerebral ischemia, L‑carnosine increased STAT3 mRNA versus vehicle at 72 h.

    In plain wordsIn rats with cerebral ischemia, L‑carnosine increased STAT3 mRNA versus vehicle.

    Peptide
    L-carnosine
    Outcome
    IncreaseSTAT3 mRNA
    Study

    ratn: not reported in source

    Permanent middle cerebral artery occlusion
    Comparator
    Vehicle
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Our results showed that the L-carnosine-treated rats had milder neurological deficits and smaller infarct volume and showed up-regulated expression in mRNA levels of STAT3 and Pim-1 than vehicle-treated rats at 72 h after treatment.
    1 context sentence
    Summary · context
    To investigate the molecular mechanisms, rat models of permanent middle cerebral artery occlusion (pMCAO) and sham operation were first established and then pMCAO and sham-operated rats were treated with L-carnosine or vehicle alone.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rats with cerebral ischemia, L‑carnosine increased Pim-1 mRNA versus vehicle at 72 h.

    In plain wordsIn rats with cerebral ischemia, L‑carnosine increased Pim-1 mRNA versus vehicle.

    Peptide
    L-carnosine
    Outcome
    IncreasePim-1 mRNA
    Study

    ratn: not reported in source

    Permanent middle cerebral artery occlusion
    Comparator
    Vehicle
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Our results showed that the L-carnosine-treated rats had milder neurological deficits and smaller infarct volume and showed up-regulated expression in mRNA levels of STAT3 and Pim-1 than vehicle-treated rats at 72 h after treatment.
    1 context sentence
    Summary · context
    To investigate the molecular mechanisms, rat models of permanent middle cerebral artery occlusion (pMCAO) and sham operation were first established and then pMCAO and sham-operated rats were treated with L-carnosine or vehicle alone.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In rats with cerebral ischemia, L‑carnosine increased pSTAT3 protein versus vehicle at 72 h.

    In plain wordsIn rats with cerebral ischemia, L‑carnosine increased pSTAT3 protein versus vehicle.

    Peptide
    L-carnosine
    Outcome
    IncreasepSTAT3 protein
    Study

    ratn: not reported in source

    Permanent middle cerebral artery occlusion
    Comparator
    Vehicle
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Meanwhile, compared with vehicle-treated rats, the L-carnosine-treated rats exhibited higher protein expressions of pSTAT3, Pim-1 and bcl-2 but lower expression of cleaved caspase-3 protein at 72 h following operation.
    1 context sentence
    Summary · context
    To investigate the molecular mechanisms, rat models of permanent middle cerebral artery occlusion (pMCAO) and sham operation were first established and then pMCAO and sham-operated rats were treated with L-carnosine or vehicle alone.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In rats with cerebral ischemia, L‑carnosine increased Pim-1 protein versus vehicle at 72 h.

    In plain wordsIn rats with cerebral ischemia, L‑carnosine increased Pim-1 protein versus vehicle.

    Peptide
    L-carnosine
    Outcome
    IncreasePim-1 protein
    Study

    ratn: not reported in source

    Permanent middle cerebral artery occlusion
    Comparator
    Vehicle
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Meanwhile, compared with vehicle-treated rats, the L-carnosine-treated rats exhibited higher protein expressions of pSTAT3, Pim-1 and bcl-2 but lower expression of cleaved caspase-3 protein at 72 h following operation.
    1 context sentence
    Summary · context
    To investigate the molecular mechanisms, rat models of permanent middle cerebral artery occlusion (pMCAO) and sham operation were first established and then pMCAO and sham-operated rats were treated with L-carnosine or vehicle alone.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In rats with cerebral ischemia, L‑carnosine increased bcl-2 protein versus vehicle at 72 h.

    In plain wordsIn rats with cerebral ischemia, L‑carnosine increased bcl-2 protein versus vehicle.

    Peptide
    L-carnosine
    Outcome
    Increasebcl-2 protein
    Study

    ratn: not reported in source

    Permanent middle cerebral artery occlusion
    Comparator
    Vehicle
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Meanwhile, compared with vehicle-treated rats, the L-carnosine-treated rats exhibited higher protein expressions of pSTAT3, Pim-1 and bcl-2 but lower expression of cleaved caspase-3 protein at 72 h following operation.
    1 context sentence
    Summary · context
    To investigate the molecular mechanisms, rat models of permanent middle cerebral artery occlusion (pMCAO) and sham operation were first established and then pMCAO and sham-operated rats were treated with L-carnosine or vehicle alone.
  8. 08AnimalAnimal study (in vivo)Mechanism

    In rats with cerebral ischemia, L‑carnosine decreased cleaved caspase-3 protein versus vehicle at 72 h.

    In plain wordsIn rats with cerebral ischemia, L‑carnosine decreased cleaved caspase-3 protein versus vehicle.

    Peptide
    L-carnosine
    Outcome
    DecreaseCleaved caspase-3 protein
    Study

    ratn: not reported in source

    Permanent middle cerebral artery occlusion
    Comparator
    Vehicle
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Meanwhile, compared with vehicle-treated rats, the L-carnosine-treated rats exhibited higher protein expressions of pSTAT3, Pim-1 and bcl-2 but lower expression of cleaved caspase-3 protein at 72 h following operation.
    1 context sentence
    Summary · context
    To investigate the molecular mechanisms, rat models of permanent middle cerebral artery occlusion (pMCAO) and sham operation were first established and then pMCAO and sham-operated rats were treated with L-carnosine or vehicle alone.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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