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Study · Non-randomized trial · n = 6 · 2013

3 results

A single injection of kisspeptin-54 temporarily increases luteinizing hormone pulsatility in healthy women.

Jayasena CN, Comninos AN, Veldhuis JD, Misra S, Abbara A, Izzi-Engbeaya C, Donaldson M, Ghatei MA, Bloom SR, Dhillo WS

Clinical endocrinology20 May 2013Cited by 38 (Europe PMC)

PMID23452073 (opens in a new tab)DOI10.1111/cen.12179 (opens in a new tab)PepBankPUB-23452073
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In healthy women, kisspeptin‑54 at the 0.30 nmol/kg dose increased the number of LH pulses after injection compared with saline.

    In plain wordsIn healthy women, kisspeptin‑54 at a medium dose raised the number of LH pulses compared with saline.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    IncreaseNumber of LH pulses per 4 h after injection
    Study

    n = 6

    Comparator
    Saline
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    0·30 nmol/kg · subcutaneous · single injectionAs given in this study (human).

    Measurements

    Mean increase in LH pulses per 4 h
    2.33 pulses
    0·30 nmol/kg kisspeptin-54
    Mean increase in LH pulses per 4 h
    −0.17 pulses
    saline

    Source sentences

    Summary
    Mean number of LH pulses was increased significantly following 0·30 and 0·60 nmol/kg kisspeptin-54 when compared with saline (mean increase in number of LH pulses per 4 h, following injection: -0·17 ± 0·54, saline; +2·33 ± 0·56, 0·30 nmol/kg kisspeptin-54, P < 0·05 vs saline; +2·33 ± 0·80, 0·60 nmol…
    1 context sentence
    Summary · context
    Six healthy female adult volunteers underwent 10-minute blood sampling for serum LH measurement for 8 h during the follicular phase of menstrual cycle. Sc bolus injection of saline or kisspeptin-54 (0·15, 0·30 or 0·60 nmol/kg) was administered 4 h after commencing the study.
  2. 02HumanNon-randomized trialEfficacy outcome

    In healthy women, kisspeptin‑54 at the 0.60 nmol/kg dose increased the number of LH pulses after injection compared with saline.

    In plain wordsIn healthy women, kisspeptin‑54 at a higher dose raised the number of LH pulses compared with saline.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    IncreaseNumber of LH pulses per 4 h after injection
    Study

    n = 6

    Comparator
    Saline
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    0·60 nmol/kg · subcutaneous · single injectionAs given in this study (human).

    Measurements

    Mean increase in LH pulses per 4 h
    2.33 pulses
    0·60 nmol/kg kisspeptin-54
    Mean increase in LH pulses per 4 h
    −0.17 pulses
    saline

    Source sentences

    Summary
    Mean number of LH pulses was increased significantly following 0·30 and 0·60 nmol/kg kisspeptin-54 when compared with saline (mean increase in number of LH pulses per 4 h, following injection: -0·17 ± 0·54, saline; +2·33 ± 0·56, 0·30 nmol/kg kisspeptin-54, P < 0·05 vs saline; +2·33 ± 0·80, 0·60 nmol…
    1 context sentence
    Summary · context
    Six healthy female adult volunteers underwent 10-minute blood sampling for serum LH measurement for 8 h during the follicular phase of menstrual cycle. Sc bolus injection of saline or kisspeptin-54 (0·15, 0·30 or 0·60 nmol/kg) was administered 4 h after commencing the study.
  3. 03HumanNon-randomized trialEfficacy outcome

    In healthy women, the mean change in LH pulse secretory mass after 0.60 nmol/kg kisspeptin‑54 was not significant compared with saline (P = 0.10).

    In plain wordsIn healthy women, the size of LH pulses did not change significantly with kisspeptin‑54 compared with saline.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    No significant changeLH pulse secretory mass after injection
    Study

    n = 6

    Comparator
    Saline
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    0·60 nmol/kg · subcutaneous · single injectionAs given in this study (human).

    Measurements

    Mean increase in pulse secretory mass
    0.35 IU/l
    saline
    Mean increase in pulse secretory mass
    2.61 IU/l
    0·60 nmol/kg kisspeptin-54

    Source sentences

    Summary
    LH pulse secretory mass increased following injection of 0·60 nmol/kg in five of six subjects, but the mean change in all subjects was non-significant when compared with saline (mean increase in pulse secretory mass in IU/l following injection: +0·35 ± 0·40, saline; +2·61 ± 1·17, 0·60 nmol/kg kisspe…
    1 context sentence
    Summary · context
    Six healthy female adult volunteers underwent 10-minute blood sampling for serum LH measurement for 8 h during the follicular phase of menstrual cycle. Sc bolus injection of saline or kisspeptin-54 (0·15, 0·30 or 0·60 nmol/kg) was administered 4 h after commencing the study.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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