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Study · Animal study (in vivo) · rat · 2013

2 results

Combination of obesity and high-fat feeding diminishes sensitivity to GLP-1R agonist exendin-4.

Duca FA, Sakar Y, Covasa M

Diabetes19 Feb 2013Cited by 58 (Europe PMC)

PMID23423571 (opens in a new tab)PMCIDPMC3712059 (opens in a new tab)DOI10.2337/db12-1204 (opens in a new tab)PepBankPUB-23423571
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In chow-fed obese-prone and obese-resistant rats, all tested exendin‑4 doses suppressed food intake.

    In plain wordsIn rats fed chow, all tested exendin‑4 doses suppressed food intake in both obesity phenotypes.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseFood intake during chow feeding
    Study

    ratn: not reported in source

    Obese-prone and obese-resistant rats
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    All doses of Ex-4 effectively suppressed intake in OP and OR rats fed chow;
    1 context sentence
    Summary · context
    Therefore, we examined the effects of exogenous intraperitoneal administration of the GLP-1R agonist, exendin-4 (Ex-4), on food intake in OP and obese-resistant (OR) rats during chow or high-energy/high-fat (HE/HF) feeding.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In high-energy/high-fat-fed rats, exendin‑4 suppressed intake less in obese-prone than obese-resistant animals at all tested doses.

    In plain wordsIn rats fed high-energy/high-fat food, exendin‑4 suppressed intake less in obesity-prone rats than obesity-resistant rats.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseFood intake suppression during high-energy/high-fat feeding
    Study

    ratn: not reported in source

    Obese-prone and obese-resistant rats
    Comparator
    Obese-resistant rats
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    however, during HE/HF-feeding, OP rats suppressed intake significantly less than OR rats at all Ex-4 doses tested.
    1 context sentence
    Summary · context
    Therefore, we examined the effects of exogenous intraperitoneal administration of the GLP-1R agonist, exendin-4 (Ex-4), on food intake in OP and obese-resistant (OR) rats during chow or high-energy/high-fat (HE/HF) feeding.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

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