The effects of carnosine in an experimental rat model of septic shock.

Sahin S, Oter S, Burukoğlu D, Sutken E

Medical science monitor basic research7 Feb 2013Cited by 14 (Europe PMC)

PMID23396325PMCIDPMC3940703DOI10.12659/msmbr.883758PepBankPUB-23396325

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In septic rats, carnosine significantly improved liver function compared with untreated sepsis.
In plain wordsIn rats with sepsis, carnosine improved liver function compared with untreated sepsis.
Peptide
L-carnosine
Outcome
Direction not reportedLiver function
Study
ratn: not reported in source
Septic shock
Comparator
Untreated sepsis
Outcome group
Liver fat and liver function · Liver
Studied dose
250 mg/kg · intraperitoneal · single injectionAs given in this study (rat).
Source sentences
Summary
Statistically significant improvements were observed in liver function, tissue and serum MDA levels, and histological findings in rats treated with carnosine, compared to rats with untreated sepsis.
2 context sentences(design, population, supporting numbers)
Summary · context
Rats were divided into control, septic shock, and carnosine-treated septic shock groups.
Summary · context
Rats in the treatment group received a single intraperitoneal (IP) injection of 250 mg/kg carnosine 60 minutes after cecal ligation-perforation.
Report a problemFND-2339632501
02AnimalAnimal study (in vivo)Activity measurement
In septic rats, carnosine significantly improved tissue MDA levels compared with untreated sepsis.
In plain wordsIn rats with sepsis, carnosine improved tissue MDA levels compared with untreated sepsis.
Peptide
L-carnosine
Outcome
Direction not reportedTissue MDA
Study
ratn: not reported in source
Septic shock
Comparator
Untreated sepsis
Outcome group
Oxidative stress · Liver
Studied dose
250 mg/kg · intraperitoneal · single injectionAs given in this study (rat).
Source sentences
Summary
Statistically significant improvements were observed in liver function, tissue and serum MDA levels, and histological findings in rats treated with carnosine, compared to rats with untreated sepsis.
2 context sentences(design, population, supporting numbers)
Summary · context
Rats were divided into control, septic shock, and carnosine-treated septic shock groups.
Summary · context
Rats in the treatment group received a single intraperitoneal (IP) injection of 250 mg/kg carnosine 60 minutes after cecal ligation-perforation.
Report a problemFND-2339632502
03AnimalAnimal study (in vivo)Activity measurement
In septic rats, carnosine significantly improved serum MDA levels compared with untreated sepsis.
In plain wordsIn rats with sepsis, carnosine improved serum MDA levels compared with untreated sepsis.
Peptide
L-carnosine
Outcome
Direction not reportedSerum MDA
Study
ratn: not reported in source
Septic shock
Comparator
Untreated sepsis
Outcome group
Oxidative stress · Whole body
Studied dose
250 mg/kg · intraperitoneal · single injectionAs given in this study (rat).
Source sentences
Summary
Statistically significant improvements were observed in liver function, tissue and serum MDA levels, and histological findings in rats treated with carnosine, compared to rats with untreated sepsis.
2 context sentences(design, population, supporting numbers)
Summary · context
Rats were divided into control, septic shock, and carnosine-treated septic shock groups.
Summary · context
Rats in the treatment group received a single intraperitoneal (IP) injection of 250 mg/kg carnosine 60 minutes after cecal ligation-perforation.
Report a problemFND-2339632503
04AnimalAnimal study (in vivo)Efficacy outcome
In septic rats, carnosine significantly improved liver histology compared with untreated sepsis.
In plain wordsIn rats with sepsis, carnosine improved liver tissue structure compared with untreated sepsis.
Peptide
L-carnosine
Outcome
Direction not reportedLiver histology
Study
ratn: not reported in source
Septic shock
Comparator
Untreated sepsis
Outcome group
Liver fat and liver function · Liver
Studied dose
250 mg/kg · intraperitoneal · single injectionAs given in this study (rat).
Source sentences
Summary
Statistically significant improvements were observed in liver function, tissue and serum MDA levels, and histological findings in rats treated with carnosine, compared to rats with untreated sepsis.
2 context sentences(design, population, supporting numbers)
Summary · context
Rats were divided into control, septic shock, and carnosine-treated septic shock groups.
Summary · context
Rats in the treatment group received a single intraperitoneal (IP) injection of 250 mg/kg carnosine 60 minutes after cecal ligation-perforation.
Report a problemFND-2339632504
05AnimalAnimal study (in vivo)Efficacy outcome
In septic rats, carnosine reduced sinusoidal dilatation compared with untreated sepsis.
In plain wordsIn rats with sepsis, carnosine reduced liver sinusoidal dilatation compared with untreated sepsis.
Peptide
L-carnosine
Outcome
DecreaseSinusoidal dilatation
Study
ratn: not reported in source
Septic shock
Comparator
Untreated sepsis
Outcome group
Liver fat and liver function · Liver
Studied dose
250 mg/kg · intraperitoneal · single injectionAs given in this study (rat).
Source sentences
Summary
Rats exposed to septic shock and treated with carnosine exhibited decreased sinusoidal dilatation and cellular inflammation into the portal region, compared to the sepsis group; the livers of rats in this group had near-normal histological structure.
2 context sentences(design, population, supporting numbers)
Summary · context
Rats were divided into control, septic shock, and carnosine-treated septic shock groups.
Summary · context
Rats in the treatment group received a single intraperitoneal (IP) injection of 250 mg/kg carnosine 60 minutes after cecal ligation-perforation.
Report a problemFND-2339632505
06AnimalAnimal study (in vivo)Efficacy outcome
In septic rats, carnosine reduced portal cellular inflammation compared with untreated sepsis.
In plain wordsIn rats with sepsis, carnosine reduced liver inflammation compared with untreated sepsis.
Peptide
L-carnosine
Outcome
DecreasePortal cellular inflammation
Study
ratn: not reported in source
Septic shock
Comparator
Untreated sepsis
Outcome group
Inflammation markers · Liver
Studied dose
250 mg/kg · intraperitoneal · single injectionAs given in this study (rat).
Source sentences
Summary
Rats exposed to septic shock and treated with carnosine exhibited decreased sinusoidal dilatation and cellular inflammation into the portal region, compared to the sepsis group; the livers of rats in this group had near-normal histological structure.
2 context sentences(design, population, supporting numbers)
Summary · context
Rats were divided into control, septic shock, and carnosine-treated septic shock groups.
Summary · context
Rats in the treatment group received a single intraperitoneal (IP) injection of 250 mg/kg carnosine 60 minutes after cecal ligation-perforation.
Report a problemFND-2339632506

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
27 Oct 2026, 18:20 UTC
Study results updated
Version 1
27 Oct 2026, 16:32 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

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