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Study · Animal study (in vivo) · sheep · 2013

9 results

Gonadotrophin-releasing hormone release into the hypophyseal portal blood of the ewe mirrors both pulsatile and continuous intravenous infusion of kisspeptin: an insight into kisspeptin's mechanism of action.

Caraty A, Lomet D, Sébert ME, Guillaume D, Beltramo M, Evans NP

Journal of neuroendocrinology1 Jun 2013Cited by 41 (Europe PMC)

PMID23387514 (opens in a new tab)DOI10.1111/jne.12030 (opens in a new tab)PepBankPUB-23387514
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In anoestrous ewes, Kp10 raised GnRH release in a dose-dependent way, with larger responses at 20 µg bolus and 20 µg/h infusion than at 10 µg doses.

    In plain wordsIn ewes, a higher Kp10 dose caused a larger GnRH release than a lower dose.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseGnRH release in hypophyseal portal blood by dose
    Study

    sheepn: not reported in source

    Anoestrous acyclic ewes
    Comparator
    10 µg dose
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    10 and 20 µg bolus; 10 and 20 µg/h infusion · intravenousAs given in this study (sheep).

    Source sentences

    Summary
    GnRH release following Kp10 administration appeared to be dose-dependent, with larger responses being seen to the 20 μg bolus and 20 μg/h infusion than to the 10 μg bolus and 10 μg/h infusion
    1 context sentence
    Summary · context
    Samples of HPB and peripheral blood were obtained at 2 and 10-min intervals, respectively, over a 6-h period, from anoestrous acyclic ewes that received an i.v. bolus injection of Kp10 at 1 h and an infusion of Kp10 between hours 2 and 6.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In anoestrous ewes, Kp10 at 10 µg bolus and 10 µg/h infusion was marginally effective in inducing LH release.

    In plain wordsIn ewes, the lower Kp10 dose only slightly raised luteinising hormone.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseLH release at 10 µg dose
    Study

    sheepn: not reported in source

    Anoestrous acyclic ewes
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    10 µg bolus and 10 µg/h infusion · intravenousAs given in this study (sheep).

    Source sentences

    Summary
    with the latter being marginally effective in inducing LH release.
    1 context sentence
    Summary · context
    Samples of HPB and peripheral blood were obtained at 2 and 10-min intervals, respectively, over a 6-h period, from anoestrous acyclic ewes that received an i.v. bolus injection of Kp10 at 1 h and an infusion of Kp10 between hours 2 and 6.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In anoestrous ewes, Kp10 bolus injections of 10 or 20 µg induced a sharp GnRH pulse in hypophyseal portal blood.

    In plain wordsIn ewes, a Kp10 injection caused a sharp pulse of GnRH.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseGnRH pulse in hypophyseal portal blood after bolus
    Study

    sheepn: not reported in source

    Anoestrous acyclic ewes
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    10 or 20 µg bolus · intravenous · single bolusAs given in this study (sheep).

    Source sentences

    Summary
    Bolus injections of Kp10 (either 20 or 10 μg) induced a sharp GnRH pulse in HPB
    1 context sentence
    Summary · context
    Samples of HPB and peripheral blood were obtained at 2 and 10-min intervals, respectively, over a 6-h period, from anoestrous acyclic ewes that received an i.v. bolus injection of Kp10 at 1 h and an infusion of Kp10 between hours 2 and 6.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In anoestrous ewes, Kp10 bolus injections of 10 or 20 µg induced a discrete LH pulse in peripheral blood.

    In plain wordsIn ewes, a Kp10 injection caused a distinct pulse of luteinising hormone in the blood.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseLH pulse in peripheral blood after bolus
    Study

    sheepn: not reported in source

    Anoestrous acyclic ewes
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    10 or 20 µg bolus · intravenous · single bolusAs given in this study (sheep).

    Source sentences

    Summary
    and a discrete LH pulse in peripheral blood.
    1 context sentence
    Summary · context
    Samples of HPB and peripheral blood were obtained at 2 and 10-min intervals, respectively, over a 6-h period, from anoestrous acyclic ewes that received an i.v. bolus injection of Kp10 at 1 h and an infusion of Kp10 between hours 2 and 6.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In anoestrous ewes, constant Kp10 infusion induced a sustained increase in baseline GnRH secretion that stayed elevated in hypophyseal portal blood.

    In plain wordsIn ewes, a steady Kp10 infusion kept GnRH levels raised.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseBaseline GnRH secretion during continuous infusion
    Study

    sheepn: not reported in source

    Anoestrous acyclic ewes
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    10 or 20 µg/h · intravenous · 4 hAs given in this study (sheep).

    Source sentences

    Summary
    By contrast, constant infusion of Kp10 (either 20 or 10 μg/h for 4 h) induced a sustained increase in baseline GnRH secretion with no convincing evidence of strictly episodic release. Values remained continuously elevated in HPB.
    1 context sentence
    Summary · context
    Samples of HPB and peripheral blood were obtained at 2 and 10-min intervals, respectively, over a 6-h period, from anoestrous acyclic ewes that received an i.v. bolus injection of Kp10 at 1 h and an infusion of Kp10 between hours 2 and 6.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In anoestrous ewes, constant Kp10 infusion showed no convincing evidence of strictly episodic GnRH release.

    In plain wordsIn ewes, a steady Kp10 infusion did not produce clear pulses of GnRH.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeEpisodic GnRH release during continuous infusion
    Study

    sheepn: not reported in source

    Anoestrous acyclic ewes
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    10 or 20 µg/h · intravenous · 4 hAs given in this study (sheep).

    Source sentences

    Summary
    with no convincing evidence of strictly episodic release.
    1 context sentence
    Summary · context
    Samples of HPB and peripheral blood were obtained at 2 and 10-min intervals, respectively, over a 6-h period, from anoestrous acyclic ewes that received an i.v. bolus injection of Kp10 at 1 h and an infusion of Kp10 between hours 2 and 6.
  7. 07AnimalAnimal study (in vivo)Safety outcome

    In anoestrous ewes, no sign of pituitary desensitisation was seen at either Kp10 concentration.

    In plain wordsIn ewes, the pituitary showed no sign of reduced response at either Kp10 dose.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changePituitary desensitisation
    Study

    sheepn: not reported in source

    Anoestrous acyclic ewes
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    10 or 20 µg/h · intravenous · 4 hAs given in this study (sheep).

    Source sentences

    Summary
    No sign of pituitary desensitisation was observed at either concentration.
    1 context sentence
    Summary · context
    Samples of HPB and peripheral blood were obtained at 2 and 10-min intervals, respectively, over a 6-h period, from anoestrous acyclic ewes that received an i.v. bolus injection of Kp10 at 1 h and an infusion of Kp10 between hours 2 and 6.
  8. 08AnimalAnimal study (in vivo)Pharmacokinetics

    In anoestrous ewes, a 500 µg intravenous Kp10 bolus produced immediate pharmacological Kp10 concentrations in the peripheral circulation.

    In plain wordsIn ewes, a large Kp10 injection gave high Kp10 levels in the blood at once.

    Peptide
    Kisspeptin-10
    Outcome
    IncreasePeripheral Kp10 concentration after 500 µg bolus
    Study

    sheepn: not reported in source

    Anoestrous acyclic ewes
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    500 µg bolus · intravenousAs given in this study (sheep).

    Source sentences

    Summary
    Finally, i.v. injection of a large bolus (500 μg) of Kp10 produced immediate pharmacological concentrations of Kp10 in the peripheral circulation
    1 context sentence
    Summary · context
    Samples of HPB and peripheral blood were obtained at 2 and 10-min intervals, respectively, over a 6-h period, from anoestrous acyclic ewes that received an i.v. bolus injection of Kp10 at 1 h and an infusion of Kp10 between hours 2 and 6.
  9. 09AnimalAnimal study (in vivo)Pharmacokinetics

    In anoestrous ewes, a 500 µg intravenous Kp10 bolus was not associated with detectable Kp10 levels in cerebrospinal fluid.

    In plain wordsIn ewes, a large Kp10 injection did not lead to detectable Kp10 in the spinal fluid.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeKp10 in cerebrospinal fluid after 500 µg bolus
    Study

    sheepn: not reported in source

    Anoestrous acyclic ewes
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    500 µg bolus · intravenousAs given in this study (sheep).

    Source sentences

    Summary
    but were not associated with detectable levels of the peptide in the cerebrospinal fluid.
    1 context sentence
    Summary · context
    Samples of HPB and peripheral blood were obtained at 2 and 10-min intervals, respectively, over a 6-h period, from anoestrous acyclic ewes that received an i.v. bolus injection of Kp10 at 1 h and an infusion of Kp10 between hours 2 and 6.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

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