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Study · Not a test of the peptide alone · 2013

4 results

Thymosin β4 is not required for embryonic viability or vascular development.

Banerjee I, Moore Morris T, Evans SM, Chen J

Circulation research1 Feb 2013Cited by 15 (Europe PMC)

PMID23371905 (opens in a new tab)PMCIDPMC3712119 (opens in a new tab)DOI10.1161/circresaha.111.300197 (opens in a new tab)PepBankPUB-23371905
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin beta-4 (human).

  1. 01AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Other

    In Tβ4 global knockout mice, no embryonic lethality was seen.

    In plain wordsIn mice bred without Tβ4, the embryos did not die more often.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    No significant changeEmbryonic lethality in Tβ4 global knockouts
    Study

    mousen: not reported in source

    Tβ4 knockout mice
    Outcome group
    Mortality · Whole body

    Source sentences

    Summary
    Examination of Tβ4 global knockouts did not demonstrate embryonic hemorrhaging, altered mural cell development, or lethality.
    1 context sentence
    Summary · context
    To investigate and clarify the role of Tβ4 in vascular smooth muscle cell development and vessel stability.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  2. 02AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Other

    In Tβ4 global knockout mice, no embryonic hemorrhaging was seen.

    In plain wordsIn mice bred without Tβ4, embryos did not show bleeding.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    No significant changeEmbryonic hemorrhaging in Tβ4 global knockouts
    Study

    mousen: not reported in source

    Tβ4 knockout mice
    Outcome group
    Cardiovascular events · Cardiovascular

    Source sentences

    Summary
    Examination of Tβ4 global knockouts did not demonstrate embryonic hemorrhaging, altered mural cell development, or lethality.
    1 context sentence
    Summary · context
    To investigate and clarify the role of Tβ4 in vascular smooth muscle cell development and vessel stability.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  3. 03AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Other

    In Tβ4 global knockout mice, mural cell development was not altered.

    In plain wordsIn mice bred without Tβ4, vessel wall cells developed normally.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    No significant changeMural cell development in Tβ4 global knockouts
    Study

    mousen: not reported in source

    Tβ4 knockout mice
    Outcome group
    Cardiovascular events · Cardiovascular

    Source sentences

    Summary
    Examination of Tβ4 global knockouts did not demonstrate embryonic hemorrhaging, altered mural cell development, or lethality.
    1 context sentence
    Summary · context
    To investigate and clarify the role of Tβ4 in vascular smooth muscle cell development and vessel stability.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  4. 04AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Other

    Endothelial-specific Tβ4 knockout mice showed no embryonic lethality and were viable to adulthood.

    In plain wordsIn mice bred without Tβ4 in blood vessel lining cells, embryos did not die and mice reached adulthood.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    No significant changeEmbryonic lethality in endothelial-specific Tβ4 knockouts
    Study

    mousen: not reported in source

    Tβ4 knockout mice
    Outcome group
    Mortality · Whole body

    Source sentences

    Summary
    Endothelial-specific knockouts also did not exhibit any embryonic lethality and were viable to adulthood.
    1 context sentence
    Summary · context
    To investigate and clarify the role of Tβ4 in vascular smooth muscle cell development and vessel stability.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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